Aaid Joi D 13 00346
Aaid Joi D 13 00346
Aaid Joi D 13 00346
Key Words: cone-beam computed tomography, mental foramen, mental nerve, anterior loop length, dental implant
S
urgery in the anterior mandible such as implant
canal, in which the inferior alveolar nerve passes through and
placement in the interforaminal area or chin grafting
continues anteriorly as the mental nerve, exiting at the mental
may damage the anterior loop of the mental nerve,
foramen. The mental nerve may have an anterior loop, which is
resulting in neurosensory disturbances. During surgery,
described in Sicher’s Oral Anatomy.7 The anterior loop is
surgeons usually expose the mental foramen to visualize the
described as ‘‘the mental canal which rises from the mandibular
position of the mental nerve. However, without knowing the
canal and runs outward, upward and backward to open at the
anterior loop length, surgeons have a high risk of violating the
mental foramen.’’ The location of the most distal implants in the
anterior loop, when present.
interforaminal area when planning an implant-supported fixed
Preoperative radiographic examination aids in developing a
complete denture is determined by the position of the mental
comprehensive treatment plan for patients who need dental
foramen and the anterior loop of the mental neurovascular
implant surgery. It helps determine the proper size, location,
bundle.8–10 To place the implant closest to the mental foramen
and angulation for each dental implant as well as the number
with concern on the anterior loop is the key factor for
of implants to be placed.1,2 Some authors claim that 2-
increasing the A-P spread and reducing distal cantilever.11,12
dimensional (2D) radiographs are sufficient for presurgical
However, complications of surgical trauma to the mental nerve
implant planning3; however, others believe there is a need for
can result in neurosensory disturbances and altered sensation
additional cross-sectional imaging.4–6 Recently, it has been
of the lower lip and chin after implant placement.13
recommended that cross-sectional imaging be used for the
Clinically, the anterior loop cannot be seen but can be
assessment of all dental implant sites and that cone-beam
detected in panoramic radiographs, cone beam computerized
computerized tomography (CT) is the imaging method of
tomography (CBCT), spiral CT, and magnetic resonance
choice for gaining this information.4
imaging. However, in the study by Arzouman et al,14 the
authors concluded that significantly fewer loops were detected
1
Advanced Education in Implant Dentistry, Department of Restorative in panoramic radiographs as compared with anatomic assess-
Dentistry, Loma Linda University, Loma Linda, Calif. ment. Also, significantly shorter anterior loops were identified
2
Department of Oral Diagnosis, Radiology & Pathology, Loma Linda
University, Loma Linda, Calif. in panoramic radiographs than when direct measurements
* Corresponding author, e-mail: chunilu1106@gmail.com were made. Moreover, Kuzmanovic et al10 showed that 50% of
DOI: 10.1563/AAID-JOI-D-13-00346 the radiographically observed anterior loops of the mental
canal were misinterpreted by observers with panoramic or 13-cm field of view, 20 seconds scan time, and 0.4-mm voxel
radiography, and 62% of the anatomically identified loops size. Both right- and left-side AnLLs were measured in each
were not observed radiographically. They concluded that subject. I-CATVision software (Croall Radiography Inc, version
panoramic radiographs are unreliable and have high incidences 1.8.1.10) was used to measure the AnLL by using multiplanar
of false-positives and false-negatives in identifying the anterior reconstruction. Multiplanar reconstruction allows images to be
loop. created from the original axial plane in either the coronal,
Spiral CT and CBCT have also been used for measuring sagittal, or oblique plane.
anterior loops in the literature and tend to be more reliable. First, the axial cut in the sagittal plane was adjusted to
Kaya et al15 showed spiral CT scans demonstrated a higher identify the best view of the mental foramen in the axial plane
prevalence of mental loops than panoramic radiographs. (Figure 1).
Uchida et al16 compared the CBCT and anatomic measurements Second, the axial plane was rotated until the sagittal cut
and concluded that the average length of the anterior loop was was parallel to the buccal plate in the area of the mental
2.2 6 0.8 mm using CBCT, and no significant differences were foramen. Meanwhile, the coronal cut in the axial plane was
found between CBCT and anatomic measurements. adjusted to identify the best view of the mental foramen in the
maximal and minimal AnLL were 6.67 mm and 2.87 mm that the previous investigators used 2D radiographs as the
(Figures 5 and 6). The mean AnLL on the right side was 1.47 6 measuring tools. Kuzmanovic et al10 concluded that panoramic
1.39 mm and on the left side was 1.44 6 1.39 mm. There was radiographs are unreliable and have high incidences of false-
no statistical significance between groups. The mean AnLL was positives and false-negatives in identifying the anterior loop.
1.51 6 1.24 mm for men and 1.40 6 1.26 mm for women, and They found that radiographic length of the anterior loop of the
no statistically significant differences were found. mental canal can be measured only in radiographs in which the
Among the age groups, 1-way ANOVA statistical analysis entire course of the mental canal is visualized, from the
showed a significant difference between groups (P ¼ .000). Both mandibular canal through the mental foramen (type I, or
post hoc tests, Bonferroni and Scheffé test, showed the AnLL of continuous type; Yosue and Brooks classification24). We applied
the 21–40 year group was significantly different from groups this concept on the 3D CBCT scans. We think that the most
41–60 and 61–80 years. The mean AnLL in the 21–40 year accurate way to measure the anterior loop is when the
group (1.89 6 1.35 mm) was larger than the AnLL in the 41–60 mandibular canal, the anterior loop, the incisive canal, and
year group (1.35 6 1.19 mm) and 61–80 year group (1.13 6 the mental foramen can be continuously visualized in the same
1.08 mm). view.
Cone beam computed tomography was introduced in the
early 2000s with its great decrease in dose compared with the
DISCUSSION conventional CT.25–27 Poeschl et al28 found that CBCT was as
In the literature, the average measurements of the AnLL varied. accurate as conventional multislice CT with regard to its use in
The mean AnLL varied from 0.1 mm19 to 6.92 mm.20 The reason image-guided implant surgery. Al-Ekrish and Ekram29 stated
that the results varied might be due to different diagnostic that the mean of the CBCT absolute errors was even smaller
tools (cadavers, dry skulls, 2D radiographs, and 3D radiographs) than that of the multi-detector CT absolute errors for the overall
different population, (different age, gender, race, dental status), data, as well as for the site-specific data. Moreover, Santana et
different methods of measuring (direct measurements using al30 and Uchida et al16 stated there was no statistically
probe, calipers), or different methods of interpreting the significant difference on the AnLL between anatomic measure-
radiographs. In our study, the mean AnLL of the 366 subjects ments from cadavers and measurements obtained from CBCT
on CBCT scans (732 hemimandibles) was 1.46 6 1.25 mm. This images. Although CBCT had been proven to be accurate,
corresponded with most of the cadaver studies that used direct studies using CBCT to analyze the average length of the
measurements. Solar et al21 found that the mean AnLL was 1 anterior loop still showed contrasting results from 0.89 mm31 to
mm and ranged from 0.5 to 5 mm, Kuzmanovic et al10 found 6.92 mm.20 We found that the methods of measuring the AnLL
the mean AnLL was 1.2 mm, and Uchida et al22 found it was 1.5 on CBCT were different. Rosa et al32 determined the mental
mm. All of these were cadaver studies. loop length on panoramic views from CBCT scans, which made
Studies by Arzouman et al,14 Kaya et al,15 and Misch and it similar to studies using panoramic radiographs. Chen et al20
Crawford23 found mean AnLLs of 3.45 mm, 3.75 mm, and 5 mm, mentioned that they reconstructed part of the panoramic view
respectively. A possible reason for these average AnLLs along the inferior alveolar nerve canal, but no reference point
compared with those of the current study could be the fact of measuring the loop was found. Apostolakis and Brown31
counted the 0.3-mm vertical cross-section slices to evaluate the voxel size might lead to a clearer image and decrease the errors
length of the loop, and we found it difficult to identify the most of measurements. However, both intra- and interexaminer
anterior part of the mental nerve on the cross-section views, reliability were analyzed in our study, and the statistic result
especially when the bone density was poor.15 The method we showed an excellent agreement. This result confirmed that the
used in our study was to locate the mental foramen and oblique transverse method was a simple and reliable way to
anterior loop on a single oblique transverse view. We believed measure the anterior loop on a CBCT scan.
that once the mandibular canal, the anterior loop, the incisive Studies that have analyzed the anterior mental loop in
canal, and the mental foramen could be simultaneously cadavers tend to consist of populations with greater age and
visualized in the same view, the measurement would be more small sample sizes. Power analysis guided us to collect at least
accurate. The presence of the anterior loop of mental nerve was 61 patients in each group, with a total of 366 patients. To the
defined as any part of the mental nerve located mesial (or best of our knowledge, this study consisted of the largest
anterior) to the mental foramen. In the present study, 85.2% sample size of all studies to report on this topic. In the present
prevalence of the loop was noted. This result was similar to the study, equal subject numbers of different genders with a wide
study of Neiva et al,33 who found 88% of anterior loop in skulls age range from 21 to 80 years were included. The statistical
using a probe, and Kieser et al,34 who found 84% in cadavers. analysis showed that there was no difference between the right
The reason that some studies showed a low prevalence (7% to and left side or between genders. Uchida et al16,22 showed no
55%)10,32,35,36 might be the difficulty of clearly identifying the difference between sides, but a larger AnLL was found in men.
most anterior portion of the mental nerve. One disadvantage in In our study, we had 5 times more subjects than the previous
the present study is that a medium-resolution CBCT with a scan study, and men showed a mean AnLL of 1.51 mm, which is
time of 20 seconds and 0.4-mm voxel size was used. Higher- slightly larger than that of women (1.40 mm) but statistically
resolution scans with a scan time of 40 seconds and 0.25-mm not significant. Moreover, we found that the AnLL of the 21–40
TABLE 1
Prevalence and measurements of the anterior loop length of the mental nerve comparing the right and left sides
Prevalence, % Min, mm Max, mm Mean 6 SD, mm
Right 85.8 2.40 6.67 1.47 6 1.39
Left 84.7 2.87 5.27 1.44 6 1.39
Paired t test (*P , .05) .639
Total 85.2 2.87 6.67 1.46 6 1.25
TABLE 2
Prevalence and measurements of the anterior loop length of the mental nerve comparing different genders
Prevalence, % Min, mm Max, mm Mean 6 SD, mm
Male 85.5 2.87 6.67 1.51 6 1.24
Female 85.0 2.47 6.40 1.40 6 1.26
Independent t test (*P , .05) .379
TABLE 3
Prevalence and measurements of the anterior loop length of the mental nerve comparing different age groups
Prevalence, % Min, mm Max, mm Mean 6 SD, mm
Age 21–40 y 89.3 2.87 6.67 1.89 6 1.35
Age 41–60 y 83.2 2.40 6.00 1.35 6 1.19
Age 61–80 y 83.2 2.20 6.60 1.13 6 1.08
One-way ANOVA (*P , .05) .000*
year age group was significant larger than the 41–60 and 61–80 have calculated the negative value when the anterior loop was
year groups. This is also consistent with Uchida et al22 and not present. However, Kieser et al34 in 2002 described 5
Ngeow et al,17 who indicated that the frequency of the anterior patterns of emergence of the human mental nerve. Type 1,
loops decreases with age. In 1986, Gershenson et al37 described referred to as a posterior directed emergence, type 2 an
TABLE 4 TABLE 5
Post hoc statistical analysis comparing different age groups Posteriorly edentulous hemimandibles in each age group
Bonferroni Test Scheffé test Posteriorly
(*P , .05) (*P , .05) Dentate Edentulous
Age 21–40 y vs 41–60 y .002* .003* Age 21–40 y 236 (96.72%) 8 (3.28%)
Age 21–40 y vs 61–80 y .000* .000* Age 41–60 y 195 (79.92%) 49 (20.08%)
Age 41–60 y vs 61–80 y .521 .396 Age 61–80 y 176 (72.13%) 68 (27.87%)
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