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Diabetes Tutorial

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Mulungushi University

School of Medicine and Health Sciences


MBChB program
Biochemistry MBI 261
2nd Year 1st semester DIABETES Tutorial XII
Prepared by Masenga SK., BSc., MSc., PgCert
1. Conrad, a 13 year old was rushed to the LCH casualty. You, the attending doctor
have done history, physical examination and labs. Some findings are shown
below including signs and symptoms:
History: insidious increased thirst and urination, nausea and vomiting with
diffuse abdominal pain, rapid weight loss, Malaise, fatigability,
Examination and vitals: mild disorientation, breath has fruity smell, xerostomia,
weak rapid pulse hyperventilation; BP 70/40,
Laboratory: ketone and glucose are present in urine, glucose-28 mmol/l, HB -
14g/dl, urea – 8.9 mmol/l, creatinine 167 µmol/l, ALT -44 IU, serum Na+
150mmol/l, K+ 5.5 mmol/l, blood pH 6.8
a. What is the diagnosis? 5 marks
b. What is the rationale for the thirst, urination, rapid weight loss, fruity
breath, hyperventilation, hypotension, high creatinine, hyperglycemia,
xerostomia and glucosuria? 20 marks
2. Differentiate diabetes type 1 and 2 – 10 marks
3. What are the classical signs of diabetes mellitus? 3 marks
4. What are the short and long term complications of T2DM – 10 marks
5. What are the risk factors for developing T2DM – 10 marks

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