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A and P Note

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Role of albumin in the blood?

Albumin is a protein found in the blood that plays several important roles in the body. Here are a few of
its main functions:

1. Maintaining blood pressure: Albumin helps to maintain blood pressure by regulating the movement of
fluids between the blood vessels and the surrounding tissues. It helps to keep the right balance of fluids
in the body, which helps to prevent swelling or edema.

2. Transporting substances: Albumin is responsible for transporting various substances, such as


hormones, fatty acids, and drugs, throughout the body. It acts as a carrier, binding to these substances
and helping to transport them to their intended destination.

3. Binding and regulating pH: Albumin can bind to and help regulate the pH (acidity) of the blood,
helping to keep it within a healthy range.

4. Providing nutrition: Albumin also plays a role in providing nutrition to the body's tissues. It carries
various nutrients, such as vitamins and minerals, to the tissues where they are needed.

Overall, albumin is an important protein in the blood that helps regulate blood pressure, transport
substances, regulate pH, and provide nutrition to the body's tissues.

What is necessary for the synthesis of prothrombin?


The synthesis of prothrombin, which is a protein involved in blood clotting, requires vitamin K.
Vitamin K is necessary to produce several clotting factors, including prothrombin. In the
absence of vitamin K, the liver is unable to produce enough prothrombin, which can result in
bleeding disorders like hemophilia. Therefore, it is important to include vitamin K-rich foods in
the diet, such as leafy green vegetables, broccoli, and certain oils like soybean and canola oil.

Where are RBC and WBC’s produced?


Red blood cells (RBCs) are produced in the bone marrow, which is a spongy tissue found inside certain
bones, such as the hip bones and the femur. White blood cells (WBCs) are also produced in the bone
marrow, as well as in the lymphatic system and spleen.

How is Oxygen carried by the blood?


Oxygen is carried by the blood through a protein called hemoglobin, which is found in red blood
cells (RBCs). Hemoglobin binds to oxygen molecules in the lungs and carries them to different
parts of the body where oxygen is needed, like the tissues and organs. When the hemoglobin
reaches these areas, it releases the oxygen molecules, allowing them to diffuse into the cells.
Carbon dioxide, which is a waste product of cellular metabolism, is then bound to hemoglobin
and carried back to the lungs to be exhaled. This process is known as gas exchange and is
essential for the body's cellular respiration and energy production.

Where is the heart located?


The heart is located in the chest or thoracic cavity, slightly to the left of the center of the chest.
It is protected by the rib cage and lies between the lungs. The base of the heart is located at the
top of the heart, where the large blood vessels enter and exit, while the apex is the bottom tip
of the heart. The heart is about the size of a closed fist and is a vital organ responsible for
pumping blood throughout the body.

What is cardiac output and calculation?


Cardiac output is the amount of blood that the heart pumps out per minute. It is calculated by
multiplying the heart rate (number of beats per minute) by the stroke volume (amount of blood
pumped out per beat). The formula for cardiac output is: Cardiac Output = Heart Rate x Stroke
Volume. For example, if the heart rate is 70 beats per minute and the stroke volume is 70
milliliters per beat, the cardiac output would be: Cardiac Output = 70 beats/minute x 70
milliliters/beat = 4,900 milliliters/minute. Therefore, in this example, the cardiac output is 4,900
milliliters per minute, which means that the heart is pumping out 4,900 milliliters (or 4.9 liters)
of blood per minute.

What is the sequence of blood flow during the heart?


The sequence of blood flow during the heart is as follows:
1. Deoxygenated blood from the body enters the right atrium of the heart through the superior
and inferior vena cava.
2. The right atrium contracts, and the blood flows through the tricuspid valve into the right
ventricle.
3. The right ventricle contracts, and the blood is pumped through the pulmonary valve and into
the pulmonary artery.
4. The pulmonary artery carries the deoxygenated blood to the lungs, where it is oxygenated.
5. The oxygenated blood returns to the heart through the pulmonary veins, entering the left
atrium.
6. The left atrium contracts, and the blood flows through the mitral valve into the left ventricle.
7. The left ventricle contracts, and the oxygenated blood is pumped through the aortic valve
and into the aorta.
8. The aorta carries the oxygenated blood to the rest of the body.
This sequence of blood flow ensures that oxygenated blood is delivered to the body's tissues
and organs while deoxygenated blood is transported to the lungs for oxygenation.

Layers of the heart?


The heart is composed of three layers:
1. Epicardium: The outermost layer of the heart is the epicardium, which is also known as the
visceral layer of the pericardium. It is a thin layer of connective tissue that covers the heart's
surface and is continuous with the inner lining of the pericardial sac that surrounds the heart.
2. Myocardium: The middle layer of the heart is the myocardium, which is the thickest layer and
is made up of cardiac muscle cells. These cells are responsible for the heart's pumping action
and are arranged in a spiral pattern that allows for efficient contraction and relaxation.
3. Endocardium: The innermost layer of the heart is the endocardium, which is a thin layer of
endothelial cells that line the heart's chambers and valves. The endocardium provides a smooth
surface for blood flow and helps to prevent blood clots.
Together, these three layers of the heart work together to ensure that the heart can pump
blood efficiently and effectively throughout the body.

How is blood supplied to the heart?


The heart is supplied with blood by its own network of blood vessels, known as the coronary
arteries. These arteries originate from the base of the aorta, which is the largest artery in the
body, and wrap around the heart's surface, supplying oxygen and nutrients to the heart muscle.
The two main coronary arteries are the left coronary artery and the right coronary artery.
The left coronary artery branches into two main arteries:
1) the left anterior descending artery (LAD), which supplies blood to the front and side of the
heart, and
2) the circumflex artery, which supplies blood to the back of the heart.
The right coronary artery supplies blood to the right side and back of the heart.
The coronary arteries also have smaller branches that supply blood to specific areas of the
heart muscle. Blood flow through the coronary arteries is regulated by a complex interplay of
factors, including hormones, nerve signals, and the body's need for oxygen and nutrients. If the
coronary arteries become narrowed or blocked due to a buildup of plaque, it can lead to a heart
attack or other serious heart conditions.

What is the cardiac cycle?


The cardiac cycle refers to the series of events that occur within the heart during one complete
heartbeat. The cardiac cycle consists of two main phases: systole and diastole.
During systole, the heart's ventricles contract and pump blood out to the lungs and body. The
atria are relaxed during this phase, allowing them to fill with blood. The first part of systole is
called isovolumic contraction, during which the ventricles contract and the pressure within
them rises, but no blood is yet ejected. Once the pressure in the ventricles exceeds the
pressure in the pulmonary artery and aorta, the semilunar valves open, and blood is ejected
into these vessels.
During diastole, the heart's ventricles relax and fill with blood from the atria. The atria contract
during this phase, pushing additional blood into the ventricles. The first part of diastole is called
isovolumic relaxation, during which the ventricles relax and the pressure within them falls, but
no blood flows into them yet. Once the pressure in the atria exceeds the pressure in the
ventricles, the atrioventricular valves open, and blood flows from the atria into the ventricles,
completing one cardiac cycle.
The cardiac cycle is essential for the heart to function effectively, pumping blood throughout
the body with each heartbeat. Any disruptions to the cardiac cycle, such as irregular heartbeats,
can affect the heart's ability to pump blood effectively and may lead to various heart
conditions.

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