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  • Aerosol Gpat Notes

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    Rajan Jatt
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    Particle size in inhalation aerosols can be determined using cascade impaction or light scattering decay techniques. Containers for aerosols must withstand certain pressures depending on their material. Metal containers can withstand pressures of 140-180 psig at 130°F while glass is less than 18 psig at 70°F. Propellants are identified using techniques like infrared spectroscopy or gas chromatography and can be soluble gases like CO2, liquefied gases, or compressed insoluble gases. Valve delivery volumes are evaluated based on DOT guidelines with volumes less than 54μl having an acceptance criteria of ±15%.

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    Aerosols

    Original Title

    AEROSOL GPAT NOTES

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    Particle size in inhalation aerosols can be determined using cascade impaction or light scattering decay techniques. Containers for aerosols must withstand certain pressures depending on their material. Metal containers can withstand pressures of 140-180 psig at 130°F while glass is less than 18 psig at 70°F. Propellants are identified using techniques like infrared spectroscopy or gas chromatography and can be soluble gases like CO2, liquefied gases, or compressed insoluble gases. Valve delivery volumes are evaluated based on DOT guidelines with volumes less than 54μl having an acceptance criteria of ±15%.

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    109 views9 pages

    Aerosol Gpat Notes

    Uploaded by

    Rajan Jatt
    Particle size in inhalation aerosols can be determined using cascade impaction or light scattering decay techniques. Containers for aerosols must withstand certain pressures depending on their material. Metal containers can withstand pressures of 140-180 psig at 130°F while glass is less than 18 psig at 70°F. Propellants are identified using techniques like infrared spectroscopy or gas chromatography and can be soluble gases like CO2, liquefied gases, or compressed insoluble gases. Valve delivery volumes are evaluated based on DOT guidelines with volumes less than 54μl having an acceptance criteria of ±15%.

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    of 9

    PRESENTED BY:

    VENKATARAO MANNEM
    PHARMACY OFFICER,
    JHARKHAND.
    Fine dispersion of solid or liquid distributed in air, where the particle/droplet size is < 50 μ
    PARTICLE SIZE SITE OF DEPOSITION

    Larger particles (>10 μ) Upper airways

    Moderate size particles (5-10 μ) Conducting airways

    Smaller particles (2-5 μ) Lower airways

    Very small particles (<2 μ) No site to deposite

    NOTE:
    Particle size in inhalation aerosols can be
    calculated by using,

    a) Cascade impactor
    b) Light scattered decay
    i. CONTAINERS

    A) Metal (s)
    ✓ Withstand a pressure of 140-180 psig at 130ᵒ F

    B) Glass
    ✓ Withstand a pressure of <18 psig at 70ᵒ F

    NOTE:
    Moisture content in inhalation aerosols can
    be determined by using,

    a) Karl Fischer Titration


    b) Gas Chromatography
    ii ) PROPELLANTS

    PROPELLANTS

    SOLUBLE GAS
    e.g., CO₂, N₂O
    Spray Pattern Test LIQUIFIED GAS COMPRESSED GAS
    (Adv.-Pressure remains constant) (Dis. Adv.-Pressure
    decreases as the
    product is used ) INSOLUBLE GAS
    e.g., N₂, Argon
    SPRAY PATTERN TEST

    FHCs HCs
    Flame Extension Test
    (Adv.- Non-Flammable) (Dis.Adv.- Flammable)
    e.g., CFCl₃ e.g., Propane
    CF₂Cl₂ Butane NOTE:
    C₂F₄Cl₂ Isobutane etc Propellants in the aerosol
    C₃H₃F₃
    product can be identified
    FLAMMABILITY TESTS by using,
    I. FLAME EXTENSION TEST
    II. FLASH POINT METHOD a) Infrared Spectroscopy
    Flash Point Method
    b) Gas Chromatography
    Nomenclature of Fluorinated Hydrocarbon Propellants

    No. H+1
    F F

    –
    –
    F–C–C–F Propellant – 1 1 4

    –
    –
    Cl Cl First digit from right
    No. C-1 indicates No. of ‘F’ atoms

    F F F F
    –

    –
    –
    –

    Cl – C – C – F P – 114 a F–C–C– F
    P – C 318

    –
    –
    –
    –

    Cl F F –C – C – F

    –
    –
    F F F F
    –
    –

    Cl – C – C – F P – 115 a
    –
    –

    F F H H H H
    P – 2 370

    –
    –
    –
    –
    C – C–C – C
    Cl F

    –
    –
    H H
    –
    –

    Cl – C – C – F P – 113 b No.of Unsaturations


    –
    –

    Cl F
    iii. Valves

    Actuator (Polyethylene/Polypropylene)

    Stem (Nylon/Delrin)

    Ferrule/Mounting Cup (Al/Stainless Steel)

    Valve Housing/Body (Nylon/Delrin)


    Gasket
    Valve Housing with specific capacity is known as Metered valve
    (Buna-N/Neoprene Rubber)
    Valve Delivery (in μl) Acceptance (in %)
    54 or Less ± 15%
    Spring
    (Stainless Steel) 55 or 200 ± 10%

    Diptube (Polyethylene/Polypropylene)
    According to Department of Transportation (DOT) guidelines,
    following evaluation tests are performed for aerosols

    Leakage Test I. Leakage test


    II. Measurement of Particle Size
    III. Determination of Moisture Content
    IV. Identification of Propellants
    V. Spray Pattern Test
    VI. Flammability Test
    Couette type
    VII. Determination of Foam Stability
    Searl type
    Foam Stability of aerosols can determined
    (Cup and Bob Viscometers) by using Rotational viscometers. Couette type (Cup in Rotation)
    e.g., Mac Michael Viscometer
    ➢ Cup and Bob Viscometer
    ➢ Cone and Plate Viscometer
    Searl type (Bob in Rotation)
    Cone and Plate Viscometer e.g., Stormer Viscometer
    Haake Roto Visco Vicsometer
    Brookfield Viscometer
    GPAT 2019
    Q). In case of aerosol testing, valve delivering acceptance criteria for a volume of 54 μl or less is:
    A) ± 5% B) ± 10% C) ± 75% D) ± 15%
    GPAT 2019
    Q). Which of the following oxide is not used for achieving amber color to glass?
    A) Carbon B) Iron C) Cobalt D) Manganese
    GPAT 2018,GPAT 2012
    Q). Containers used for Aerosols should withstand a pressure of
    A) 130 – 150 Psig at 130ᵒF
    B) 140 – 180 Psig at 130ᵒF
    C) 140 – 170 Psig at 120ᵒF
    D) 120 – 140 Psig at 120ᵒF
    GPAT 2011
    Q). DOT is performed for which of the following
    A) Strip packing B) Aerosol C) Injection packing D) Glass containers
    NIPER 2009
    Q). Imagine that you are developing an aerosol drug formulation to the delivery of drugs into
    conducting air ways which particle size you will choose
    A) >10 μ B)5 – 10 μ C) <2 μ D) All of the above
    THANK YOU

    Address: HYDERABAD ACADEMY


    (Online & Offline GPAT Coaching Center)

    Email address:
    venkatraoceutics@gmail.com

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