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    MEGARes

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    mcdonald212
    MEGARes is a curated database of antibiotic, metal, and biocide resistance genes compiled from published sequences. It contains over 8,700 gene accessions classified into four drug classes, 59 mechanisms of resistance, and 1,448 gene groups. MEGARes allows large-scale metagenomic sequence analysis of resistance at the population level and integrates with the AMR++ bioinformatics pipeline for resistome classification.

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    MEGARes

    Uploaded by

    mcdonald212
    17 views2 pages
    MEGARes is a curated database of antibiotic, metal, and biocide resistance genes compiled from published sequences. It contains over 8,700 gene accessions classified into four drug classes, 59 mechanisms of resistance, and 1,448 gene groups. MEGARes allows large-scale metagenomic sequence analysis of resistance at the population level and integrates with the AMR++ bioinformatics pipeline for resistome classification.

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    MEGARes is a curated database of antibiotic, metal, and biocide resistance genes compiled from published sequences. It contains over 8,700 gene accessions classified into four drug classes, 59 mechanisms of resistance, and 1,448 gene groups. MEGARes allows large-scale metagenomic sequence analysis of resistance at the population level and integrates with the AMR++ bioinformatics pipeline for resistome classification.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    17 views2 pages

    MEGARes

    Uploaded by

    mcdonald212
    MEGARes is a curated database of antibiotic, metal, and biocide resistance genes compiled from published sequences. It contains over 8,700 gene accessions classified into four drug classes, 59 mechanisms of resistance, and 1,448 gene groups. MEGARes allows large-scale metagenomic sequence analysis of resistance at the population level and integrates with the AMR++ bioinformatics pipeline for resistome classification.

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    MEGARes

    MEGARes is a hand-curated antibiotic resistance database which


    incorporates previously published resistance sequences for
    MEGARes
    antimicrobial drugs, while also expanding to include published Content
    sequences for metal and biocide resistance determinants. In Description MEGARes is an
    MEGARes 3.0, the nodes of the acyclic hierarchical ontology
    antimicrobial
    include four antimicrobial compound types, 59 classes, 223
    resistance
    mechanisms of resistance, and 1,448 gene groups that classify the
    database made
    8,733 gene accessions. [1][2][3] This works in conjunction with the
    AMR++ bioinformatics pipelin (version 3.0) to classify resistome for high
    sequences directly from FASTA. throughput
    sequencing
    The database focuses on the analysis of large-scale, ecological based at
    sequence datasets with an annotation structure that allows for the collaborating
    development of high throughput acyclical classifiers and centers
    hierarchical statistical analysis of big data. MEGARes annotation
    consists of three hierarchical levels when looking at AMR genes: Data types Antimicrobial
    drug class, mechanism, and group. The comprehensive captured resistance genes
    MEGARes content was compiled from all published sequences and phenotypes
    included various other databases: Resfinder, ARG-ANNOT, Organisms Bacteria
    Comprehensive Antibiotic Resistance Database (CARD), and the
    National Center for Biotechnology Information (NCBI) Lahey Contact
    Clinic beta-lactamase archive. Research center Texas A&M
    University,
    MEGARes allows users to analyze antimicrobial resistance on a University of
    population-level, similar to a microbiome analysis, from a FASTA
    Minnesota,
    sequence. Furthermore, users can access AMR++, a
    University of
    bioiinformatics pipeline for resistome analysis of metagenomic
    datasets that can be integrated with the MEGARes database. Florida,
    Colorado State
    Uninversity
    See also
    Primary citation PMID 27899569
    Antimicrobial Resistance databases (https://pubmed.
    ncbi.nlm.nih.gov/
    27899569)
    References
    Access
    1. Lakin SM, Dean C, Noyes NR, Dettenwanger A, Ross
    Website http://meglab.org
    AS, Doster E, Rovira P, Abdo Z, Jones KL, Ruiz J, Belk
    (http://meglab.or
    KE, Morley PS, Boucher C. MEGARes: an antimicrobial
    resistance database for high throughput sequencing. g)
    Nucleic Acids Res. 2017 Jan 4;45(D1):D574-D580. Download URL Download (http
    https://doi.org/10.1093/nar/gkw1009. s://megares.meg
    2. Doster E, Lakin SM, Dean CJ, Wolfe C, Young JG, lab.org/downloa
    Boucher C, Belk KE, Noyes NR, Morley PS. MEGARes d/index.php)
    2.0: a database for classification of antimicrobial drug,
    biocide and metal resistance determinants in Miscellaneous
    metagenomic sequence data. Nucleic Acids Res. 2020
    Jan 8;48(D1):D561-D569. Bookmarkable yes
    https://doi.org/10.1093/nar/gkz1010 entities
    3. Bonin N, Doster E, Worley H, Pinnell LJ, Bravo J, Ferm
    P, Marini S, Prosperi M, Noyes NR, Morley PS, Boucher C. MEGARes and AMR++, v3.0: An
    updated comprehensive database of antimicrobial resistance determinants and an improved
    software pipeline for classification using high-throughput sequencing. Nucleic Acids Res
    2022 gkac1047. https://doi.org/10.1093/nar/gkac1047.

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