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Parathyroid Drugs

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PARATHYROID CA METABOLISMDRUGS

HORMONAL REGULATORSOFBONEMINERALHOMEOSTASIS 2 HORMONALREGULATORSOFBONEMINERALHOMEOSTASIS


JARATHYROIDHORMONE PARAFOLLICULAR
THYROIDHORMONE
teriparatide PTHanalog calcitonin

parenteral Hdaypulsatile bone


administration formation Marcel's thyroid secrete
gland c alcitonin antagonize actions

totreat
used when
osteoporosis ineffectivetextremebonelossloracturesocurred
bisphosphonates

other inhibit
drugs
osteoporosis bone this.esmuatesbonemmon
resorption
painassociatedwosteoporoticfracture
relieves
adverse
effects useshypercalcemianotestine
therapeutic

term
tolerancedevelops continuouslong
use
hypercalcemia nausea energy
vomitingconstipation muscreweanness
w of
production anticalcitoninantibodies

in adverse
effects
nasal
spray rhinitis
irritation nasal
of mucosa
VITAMINS D CALCIFEROLS epistaxis

ergocalciferolvitD2
cholecalciferol vitD3 flushing
calcitriol HA
paricalcitol test
skin priortoinitiating totestforallergicran
therapy

calcipotriene limited warnings other


efficacy safety options calcitoninno
longerrecommended

I Carpoyrenalexcretion
I'CatPoyreabsorption OTHERS
boneformation egg
mum of
usesp revention postmenopausalboneless
therapeutic

bileessentialforvito intestinalabsorption prevent


osteoporosis riskorniporacture

adverseeffects lastboneresorbingactionorpat
hypercalcemia
Triska
hyperphosphatemia especially inptswrenalfailure breast
cancer

noteFGF23inhibitscalcitriolsynth Poy reabsorption endometrial


cancer

stone
venousthromboembolism

disease
coronary

SERMS Raloxifene
linealternativeforpostmenopausalosteoporosisa intoleranttobisphosphonates
first
abone
densitywloutanisnor cancer brisk
endometrial breast
invasive cancer

glucocorticoids
OTHERDRUGSAFFECTINGBONEMINERALHOMEOSTASIS

BISPHOSPHONATES CALCIMIMETIC Agents


alendronate2nd
g eneration potency dayor ween cinacalet
samidronate2nd
g eneration impotencyoniyoneapprovedforivuseinpagets bindcasronchiefcellsinPTgland PTH
inhibit secretion
adverse
effects
bind tohydroxyapatite
d irectly crystaisinbone stbonecensityrtfractures Nlrb
hypercalcemia

Tosteoclasticapoptosistosteoclasticactivity some
inhibit
farnesyl synthase
pyrophosphate arthralgiamyalgia
agents
antiresorptive uses
therapeutic

uses
therapeutic

iiii
disease
Paget's 1 hyperparathyroidism duetoptadenomalcarcinoma

of
t reatment osteoporosis
prevention

inducedosteoporosis
glucocorticoid

hypercalcemia

mm
other
bone
diseasesw itboneresorption

very oral
poor bioavailability whentanenwlmeals

drug
manygood for
interactions absorption takeonempty
stomach 1hrbefore adverse
effects
remain
breakfast upright30minprevent
esophagitis donotgiveoraitobedriddenpts vivid

tpoytptttdoesnottc .gg
donotgiveto ptsw severerenalimpairmentsolelyrenallycleared dyspepsia

adverse
effects therapeutic
of
usesmanagement hyperphosphatemiainesropts

diarrhea

q
erosion
esophagealulceration
gym
osteonecrosisofjawcons sesp.nozoedronateontivaose monoclonalantibody Ravin
against inhibit
osteoclast
formation stboneresorption

IMHomo
therapeutic usepostmenopausalosteoporosisinsultriskoffracture
adverse
effects

nypocalcemi .osteonecrosisqjaw

ns
expensivelsz.ooo
year administration
fees e lectrolytes
monitoring

calcium
phosphate

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