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    2.pituitary Adenoma

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    張宏軒
    1) Pituitary adenomas account for 10-15% of intracranial tumors and occur most commonly in those aged 30-40, with higher rates in women. 2) They are benign neuroendocrine tumors composed of hormone-producing or non-hormone producing cells that proliferate in the anterior pituitary gland. 3) They are classified based on size (microadenomas <1cm, macroadenomas ≥1cm) and tumor type based on predominant hormone production.

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    2.pituitary Adenoma

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    張宏軒
    8 views2 pages
    1) Pituitary adenomas account for 10-15% of intracranial tumors and occur most commonly in those aged 30-40, with higher rates in women. 2) They are benign neuroendocrine tumors composed of hormone-producing or non-hormone producing cells that proliferate in the anterior pituitary gland. 3) They are classified based on size (microadenomas <1cm, macroadenomas ≥1cm) and tumor type based on predominant hormone production.

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    2.Pituitary adenoma

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    1) Pituitary adenomas account for 10-15% of intracranial tumors and occur most commonly in those aged 30-40, with higher rates in women. 2) They are benign neuroendocrine tumors composed of hormone-producing or non-hormone producing cells that proliferate in the anterior pituitary gland. 3) They are classified based on size (microadenomas <1cm, macroadenomas ≥1cm) and tumor type based on predominant hormone production.

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    8 views2 pages

    2.pituitary Adenoma

    Uploaded by

    張宏軒
    1) Pituitary adenomas account for 10-15% of intracranial tumors and occur most commonly in those aged 30-40, with higher rates in women. 2) They are benign neuroendocrine tumors composed of hormone-producing or non-hormone producing cells that proliferate in the anterior pituitary gland. 3) They are classified based on size (microadenomas <1cm, macroadenomas ≥1cm) and tumor type based on predominant hormone production.

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    Pituitary adenoma By 陳峯州

     流行病學:
     佔顱內腫瘤的 10~15％
     發生年紀主要在 30~40 歲,女性有較高的發生率
     1/4 的屍體解剖有發現 incidental adenoma
     Prevalence of 0.2% for incidental pituitary macroadenoma (> 1 cm) in living patients

     簡介:
     定義:
    Neuroendocrine tumor of the anterior pituitary gland composed of secretory cells
    with pituitary hormone production
    Benign tumor of proliferations of anterior pituitary gland cells
    Can be classified as functional (Hormone-producing) or non-functional (Silent, or no
    obvious hormone producing)

     分類:
     按照大小:
    Tumor < 1 cm (Microadenoma)
    Tumor ≧ 1 cm (Macroadenoma)
     按照 tumor types:
    Somatotroph
    Lactotroph
    hyrotroph
    Corticotroph
    Gonadotroph
    Null cell
    Plurihormonal(分泌各種 hormone)
    以上 tumr types 的分類是依靠 Immunohistochemical staining for main pituitary
    hormones (GH, PRL, ACTH, beta TSH, beta LH, beta FSH and alpha subunit of
    glycoproteins)或是可以利用 pituitary transcription factors staining(PIT1, SF1, T-
    PIT) 老師說不會考

     臨床表現:
     Nonfunctional tumors often present with mass effect
     Functional tumors often with clinical symptoms(hormone related) before mass effect
     必考題:
    Bitemporal hemianopsia occurs due to compression of the optic chiasm

    ※有沒有很懷念
    Hypopituitarism occurs due to compression of normal pituitary tissue
    Headache

     病理評估:
     Evaluation of tumor proliferation potential:
    mitotic count
    Ki-67 labeling index
     Evaluation of tumor invasion to identify clinically aggressive adenoma
     Routine stains including ACTH, prolactin, growth hormone, TSH, LH, FSH, chromogranin,
    p53 and in some cases hormone receptor stains and transcription factors 我覺得不用背
     use of transcription factors (SF1, T-PIT, PIT1) IHC to determine adenoma lineage 我覺得
    不用背

     Pituitary adenoma vs Pituitary carcinoma


     必考題: There is no histologic distinction between typical pituitary adenoma and
    carcinoma 一個腦下垂體的病理檢體送過來,病理科醫師無法確定到底是 adenoma 還
    是 carcinoma,因為沒有 criteria
     Diagnosis of pituitary carcinoma is based on presence of cerebrospinal fluid or systemic
    metastases (有看到轉移時,病理科醫師才能寫 carcinoma,講幹話~)

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