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    Jo anne Jo anne
    The sputum sample from Mr. Joseph Lukas tested positive for Mycobacterium tuberculosis complex which was found to be resistant to rifampicin based on the GeneXpert MTB/Rif Ultra test, additional molecular testing also detected resistance to isoniazid, amikacin, and ethionamide, with the report recommending the patient be urgently referred for drug resistant TB treatment.

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    The sputum sample from Mr. Joseph Lukas tested positive for Mycobacterium tuberculosis complex which was found to be resistant to rifampicin based on the GeneXpert MTB/Rif Ultra test, additional molecular testing also detected resistance to isoniazid, amikacin, and ethionamide, with the report recommending the patient be urgently referred for drug resistant TB treatment.

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    The sputum sample from Mr. Joseph Lukas tested positive for Mycobacterium tuberculosis complex which was found to be resistant to rifampicin based on the GeneXpert MTB/Rif Ultra test, additional molecular testing also detected resistance to isoniazid, amikacin, and ethionamide, with the report recommending the patient be urgently referred for drug resistant TB treatment.

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    17 views2 pages

    Websys

    Uploaded by

    Jo anne Jo anne
    The sputum sample from Mr. Joseph Lukas tested positive for Mycobacterium tuberculosis complex which was found to be resistant to rifampicin based on the GeneXpert MTB/Rif Ultra test, additional molecular testing also detected resistance to isoniazid, amikacin, and ethionamide, with the report recommending the patient be urgently referred for drug resistant TB treatment.

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    of 2

    GEORGE LABORATORY

    Block F1 George Hospital, Langenhoven Street, George, WC, 6529


    Tel: 044 874 2022/3 or 874 4628, Fax: 044 874 6175
    Practice Number 5200296 pg 1 of 2

    LABORATORY REPORT
    PATIENT: LAB NUMBER: XB 01665788 REPORT TO:
    Mr Joseph LUKAS
    20/12/82 (40y) Sex M Sample Ref: ANBK2160P Sr S.R. MULLER
    Race: Unknown Collected: 27/07/2023 20:00 Ward not stated
    ID no: 821220 5229 08 4 Received: 28/07/2023 15:45 Riversdale Clinic wc RAV
    SONSKYNSTR 262 1st Print: 30/07/2023 07:01 Private Bag X421
    Morestond Reprint: 03/08/2023 12:17 Riversdale
    Western Cape Western Cape
    6670 6670

    Patient Location: Riversdale Clinic wc RAV, Ward not stated


    Hospital Number: 120362678

    DISCLAIMER: If the date or time of collection is not included on the request form or the sample
    does not meet our laboratory requirement for collection, transport and processing,
    caution should be exercised when interpreting results as their accuracy cannot be guaranteed.
    Absent clinical details may affect the laboratory's interpretation of results.

    FOR ENQUIRIES AND FOLLOW-UP TESTS, PLEASE QUOTE PATIENT'S MRN NUMBER MRN49816826

    MICROBIOLOGY
    Specimen received: Sputum (Suspect new : 0mths)
    Tests requested: GeneXpert Ultra, TB mic @, TB cult @, GeneXpert XDR CS @
    @ Test referred to another NHLS laboratory

    Real time PCR for M. tuberculosis (Xpert MTB/Rif Ultra):


    PCR result Mycobacterium tuberculosis complex detected
    Rifampicin (molecular) Resistant

    This patient has presumptive MDR-TB. Please refer URGENTLY to an appropriate


    treatment facility and refer to the Drug Resistant TB management guidelines.

    Auramine O Stain:
    Result (concentrated) - IUALTD Negative (No AFB observed in one length)

    Molecular resistance testing for MTB: TB PCR DR-TB (Clinical Sample):


    PCR result Mycobacterium tuberculosis complex detected
    Isoniazid, INH (molecular) Low resistance
    Fluoroquinolones, FLQ (molecular) Sensitive
    Amikacin, AMK (molecular) Resistant
    Ethionamide, ETH (molecular) Resistant

    Interpretative comments:
    1. Mutations associated with low-level Isoniazid resistance were detected.

    2. No mutations conferring resistance to the Fluoroquinolones (FLQ) were


    detected. This assay is able to detect 94% of FLQ resistance.

    3. Mutations associated with Amikacin resistance were detected.

    4. Mutations associated with Ethionamide resistance were detected.

    NB. Please correlate with current genotypic Rifampicin result, to determine


    the drug resistance classification. Phenotypic drug-susceptibility results
    of additional second-line drugs to follow.
    GEORGE LABORATORY
    Block F1 George Hospital, Langenhoven Street, George, WC, 6529
    Tel: 044 874 2022/3 or 874 4628, Fax: 044 874 6175
    Practice Number 5200296 pg 2 of 2
    Mr Joseph LUKAS LAB NO: XB 01665788 27/07/2023 20:00
    Riversdale Clinic wc RAV, Ward not stated, Hospital Number 120362678

    @ GeneXpert XDR CS, TB cult, TB mic referred to Green Point Laboratory


    (Tel 021 417 9360/1)

    Authorised by: Dr CJ Opperman (Pathologist) GeneXpert XDR CS


    R Klaasen (Medical Technologist) GeneXpert Ultra
    W Harricombe (Medical Technologist) TB mic

    -- End of Laboratory Report --

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