Grade-12a - Biology - Worksheet-5 (08.09.23)

Date: 08.09.
23 Grade: 12
Subject: BIOLOGY Worksheet No: 5
Chapter / Topic: CH-6 MOLECULAR BASIS OF INHERITANCE
I. The picture here shows the structure of DNA. Observe the picture and answer the following
questions:
1. Name the sugar present in DNA.

2. How many hydrogen base pairs are present between
Guanine and cytosine?
3. How is phosphoester linkage different from phospho
di ester linkage?
4. Who proposed the double helix model for the
structure of DNA?
5. Why do the two chains of DNA have anti-parallel
polarity?
II. Complete the table given below:
S.NO Name of the scientists/ Experimental work Conclusion/ Result of the experiment
Genetists/ biochemists performed performed
1 Hershey-Chase
2 Transformation
3 Biochemical nature of transforming principle
4 Meselson and Stahl
5 X- ray diffraction data of DNA
III. Name the function of the following enzymes:
DNA polymerase helicase ligase topoisomerase DNA dependent RNA polymerase
Beta galactosidase RNA polymerase restriction endonuclease peptidase
IV. Differentiate m-RNA, r-RNA and t- RNA

V. Find the best option:
1. In a nucleotide, the nitrogen base is joined to the sugar molecule by
a) Phosphodiester bond b) Glycosidic bond c) Hydrogen bond d) (a) &(b)

2. If a double stranded DNA has 20% Thymine, the percentage of Guanine in the DNA
a) 30% b) 10% c) 90% d) 40%
3. If a DNA contains 1000 base pairs, what would be its length?
a) 3400 Å b) 34000 Å c) 6800 d) 1000 Å
4. What is not True for DNA in prokaryotes
a) present in the form of a compact structure called nucleoid
b) the coils are maintained by non-histone basic proteins
c) found in cytoplasm in a supercoiled condition
d) packaged as nucleosomes along with histones
5. Pick the right difference between a DNA and RNA
a) Sugar and phosphate b) sugar and purines c) purines and phosphate d) sugar and pyrimidines
6. In the following questions, a statement of Assertion (A) is followed by a statement of Reason (R).
(1) If both Assertion and Reason are true and the reason is the correct explanation of the assertion,
then mark (a)
(2) If both Assertion and Reason are true but the reason is not the correct explanation
of the assertion, then mark (b)
(3) If Assertion is true but Reason are false, then mark (c)
(4) If Assertion is false but Reason are true, then mark (d)
Assertion: In Griffith’s experiment mice were injected by a mixture of heat killed Smooth type
bacteria and live Rough type bacteria. Some mice died of pneumonia and their blood contained both
live Rough type bacteria and live Smooth type bacteria.
Reason: The dead Smooth type bacteria became alive and caused pneumonia. Griffith named it as
transforming principle.
7. Hershey and Chase experiment proving DNA as the genetic material was based on the principle
a) Transduction b) transformation c) transcription d) translation
8. A bacterial colony containing DNA made up of 100% N15 nitrogen bases is allowed to replicate in
a medium containing N14 bases. After one round of replication the result would be
a) All individuals will be identical to parents b) All individuals will be hybrids
c) Only 50% individuals would be hybrids d) All individuals would have DNA made up of
100% N14
9. The coding sequences found in split genes are called
a) Operons b) introns c) exons d) cistrons
10. Cistron is
a) The coding sequence of DNA b) The functional unit of DNA molecule that codes for a particular
gene product
c) Intervening non coding sequence of DNA

1.
d) The sequences which are removed during RNA 2.
splicing. 3.
4.
VI. Observe the picture and any 5 points relevant 5.
to the process taking place.
VI. Answer the following questions by observing the given picture:

1) Which process is depicted in this picture?
2) Write any two application of this process.
3) How is satellite DNA different from repetitive DNA?
4) Define DNA polymorphism.
5) Write the principle behind this process in three lines.
6) What is the purpose of using labeled probes?
7) Explain the process of southern hybridization.

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Grade-12a - Biology - Worksheet-5 (08.09.23)

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Date: 08.09.

Subject: BIOLOGY Worksheet No: 5

Chapter / Topic: CH-6 MOLECULAR BASIS OF INHERITANCE

1. Name the sugar present in DNA.

II. Complete the table given below:

Genetists/ biochemists performed performed

3 Biochemical nature of transforming principle

4 Meselson and Stahl

5 X- ray diffraction data of DNA

III. Name the function of the following enzymes:

DNA polymerase helicase ligase topoisomerase DNA dependent RNA polymerase

Beta galactosidase RNA polymerase restriction endonuclease peptidase

IV. Differentiate m-RNA, r-RNA and t- RNA

1. In a nucleotide, the nitrogen base is joined to the sugar molecule by

a) Phosphodiester bond b) Glycosidic bond c) Hydrogen bond d) (a) &(b)

a) 30% b) 10% c) 90% d) 40%

3. If a DNA contains 1000 base pairs, what would be its length?

a) 3400 Å b) 34000 Å c) 6800 d) 1000 Å

4. What is not True for DNA in prokaryotes

a) present in the form of a compact structure called nucleoid

b) the coils are maintained by non-histone basic proteins

c) found in cytoplasm in a supercoiled condition

d) packaged as nucleosomes along with histones

5. Pick the right difference between a DNA and RNA

of the assertion, then mark (b)

a) Transduction b) transformation c) transcription d) translation

a) All individuals will be identical to parents b) All individuals will be hybrids

a) Operons b) introns c) exons d) cistrons

c) Intervening non coding sequence of DNA

VI. Answer the following questions by observing the given picture:

2) Write any two application of this process.

3) How is satellite DNA different from repetitive DNA?

4) Define DNA polymorphism.

5) Write the principle behind this process in three lines.

6) What is the purpose of using labeled probes?

7) Explain the process of southern hybridization.

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