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    Formulation and Evaluation of Xanthine Gum Based Ketoconazole Anti Dandruff Shampoo

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    suniel8080
    This document describes the formulation and evaluation of a ketoconazole anti-dandruff shampoo using xanthine gum as the base. Ketoconazole is an antifungal drug used to treat fungal infections like dandruff. The researchers formulated a 2% ketoconazole shampoo with 1.1% xanthine gum, 15% sodium lauryl sulfate, 5% glycerin and 0.02% disodium EDTA. The shampoo was evaluated and found to have a clear liquid gel appearance and viscosity of 85.7 mPa at 1.4 rpm. It produced foam that was stable for 5 minutes and had a 74.6% cleaning

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    Formulation and Evaluation of Xanthine Gum Based Ketoconazole Anti Dandruff Shampoo

    Uploaded by

    suniel8080
    18 views2 pages
    This document describes the formulation and evaluation of a ketoconazole anti-dandruff shampoo using xanthine gum as the base. Ketoconazole is an antifungal drug used to treat fungal infections like dandruff. The researchers formulated a 2% ketoconazole shampoo with 1.1% xanthine gum, 15% sodium lauryl sulfate, 5% glycerin and 0.02% disodium EDTA. The shampoo was evaluated and found to have a clear liquid gel appearance and viscosity of 85.7 mPa at 1.4 rpm. It produced foam that was stable for 5 minutes and had a 74.6% cleaning

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    Anti dendruf formula

    Original Title

    A089

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    This document describes the formulation and evaluation of a ketoconazole anti-dandruff shampoo using xanthine gum as the base. Ketoconazole is an antifungal drug used to treat fungal infections like dandruff. The researchers formulated a 2% ketoconazole shampoo with 1.1% xanthine gum, 15% sodium lauryl sulfate, 5% glycerin and 0.02% disodium EDTA. The shampoo was evaluated and found to have a clear liquid gel appearance and viscosity of 85.7 mPa at 1.4 rpm. It produced foam that was stable for 5 minutes and had a 74.6% cleaning

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    18 views2 pages

    Formulation and Evaluation of Xanthine Gum Based Ketoconazole Anti Dandruff Shampoo

    Uploaded by

    suniel8080
    This document describes the formulation and evaluation of a ketoconazole anti-dandruff shampoo using xanthine gum as the base. Ketoconazole is an antifungal drug used to treat fungal infections like dandruff. The researchers formulated a 2% ketoconazole shampoo with 1.1% xanthine gum, 15% sodium lauryl sulfate, 5% glycerin and 0.02% disodium EDTA. The shampoo was evaluated and found to have a clear liquid gel appearance and viscosity of 85.7 mPa at 1.4 rpm. It produced foam that was stable for 5 minutes and had a 74.6% cleaning

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    See discussions, stats, and author profiles for this publication at: https://www.researchgate.

    net/publication/235337306

    FORMULATION AND EVALUATION OF XANTHINE GUM BASED KETOCONAZOLE


    ANTI DANDRUFF SHAMPOO

    Conference Paper · March 2011


    DOI: 10.13140/2.1.1216.0007

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    4 authors, including:

    Sailaja Kona Subbaiah Kandasami Umadevi

    4 PUBLICATIONS 0 CITATIONS
    Yeungnam University
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    FORMULATION AND EVALUATION OF XANTHINE GUM BASED
    KETOCONAZOLE ANTI DANDRUFF SHAMPOO
    K. Sailaja*, K. Jayaraj kumar, Dr. S.K. Umadevi, B. Lakshmi Narasamma,
    P. Nithyaswi, R. Naveen chakravarthi, M. Viswanath Reddy, M.Jeyakanthan
    Dept. of Pharmaceutics, Rao’s college of pharmacy, Nellore, A.P.
    e-mail: sailaja.kona1@gmail.com

    Abstract
    Ketoconazole is a synthetic anti fungal drug used to prevent and treat fungal
    infections especially in immunocompromised patients. In today’s stressful world,
    dandruff has become an increasingly common ailment. This anti dandruff shampoo is
    designed for people who have a more serious case of dandruff where symptoms include,
    but are not limited to constant non stop flaking and severe itchiness. Ketoconazole acts as
    an antifungal agent principally by inhibiting the enzyme cytochrome P450 14 alpha
    demethylase (p450 14DM).It also interferes with the fungal synthesis of ergo sterol, a
    constituent of fungal cell membranes, as well as certain enzymes. The anti dandruff
    shampoo was formulated by using ketoconazole (2%w/v) , xanthine gum (1.1%w/v) ,
    sodium lauryl sulphate (15%w/v) , glycerin (5%w/v) , disodium EDTA (0.02%w/v).
    Then the optimized formulation were evaluated for visual appearance (clear, liquid gel) ,
    viscosity (85.7mpa at 1.4 rpm) , foam and foam stability (1.4cm, 0.6cm after 5 minutes) ,
    cleaning action (74.6%) , wetting time (35 minutes) and eye irritancy test (no eye
    irritancy was found in rabbit eye).Thus this xanthine gum based shampoo showed
    effective anti-dandruff activity.

    Keywords: Ketoconazole Cytochrome P450 14 alpha demethylase, Xanthin gum,

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