ChemicalBook

Chemical Safety Data Sheet MSDS / SDS

Trichloroacetic acid
Revision Date:2023-12-02 Revision Number:1

SECTION 1: Identification of the substance/mixture and of the

company/undertaking

Product identifier

Product name : Trichloroacetic acid

CBnumber : CB9854255
CAS : 76-03-9
EINECS Number : 200-927-2
Synonyms : TCA,trichloroacetic acid

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses : For R&D use only. Not for medicinal, household or other use.
Uses advised against : none

Company Identification

Company : Chemicalbook
Address : Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone : 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal word Danger

Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continuerinsing.
P370+P378 In case of fire: Use … for extinction.
P391 Collect spillage. Hazardous to the aquatic environment

Chemical Book 1
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…
Hazard statements
H225 Highly Flammable liquid and vapour
H314 Causes severe skin burns and eye damage
H315 Causes skin irritation
H318 Causes serious eye damage
H335 May cause respiratory irritation
H336 May cause drowsiness or dizziness
H351 Suspected of causing cancer
H373 May cause damage to organs through prolonged or repeated exposure
H400 Very toxic to aquatic life
H401 Toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects
H411 Toxic to aquatic life with long lasting effects
H412 Harmful to aquatic life with long lasting effects
Disposal
WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/trichloroacetic-acid

SECTION 3: Composition/information on ingredients

Substance

Product name : Trichloroacetic acid

Synonyms : TCA,trichloroacetic acid
CAS : 76-03-9
EC number : 200-927-2
MF : C2HCl3O2
MW : 163.39

SECTION 4: First aid measures

Description of first aid measures

General advice
First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
If swallowed
Chemical Book 2
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not
attempt to neutralise.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Hydrogen chloride gas Combustible.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable
protective clothing.

Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the
ground water system.

NFPA 704

0
3 0

Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium
HEALTH 3
hypochlorite, hexafluorosilicic acid)

Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete,
FIRE 0 stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5
minutes.(e.g. Carbon tetrachloride)

REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)

Chemical Book 3
 SPEC.
HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger
area, observe emergency procedures, consult an expert.
For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of
properly. Clean up affected area. Avoid generation of dusts.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Store under nitrogen.

Tightly closed. Dry.

Storage stability

Recommended storage temperature 2 - 8 °C

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.
Chemical Book 4
Exposure controls

Personal protective equipment

Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly
fitting safety goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving
in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:KCL 741 Dermatril? L
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving
in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved
gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,11 mm Break through time: 480 min
Material tested:KCL 741 Dermatril? L
Body Protection
Acid-resistant protective clothing
Respiratory protection
Recommended Filter type: Filter type B
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the
instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearance off-white crystalline

Odour stinging
Odour Threshold No data available
pH 1 at 81,7 g/l at 25 °C
Melting point/freezing point Melting point/range: 54 - 58 °C - lit.
Initial boiling point and boiling range 196 °C - lit.
Flash point >113 °C - closed cup
Evaporation rate No data available
Flammability (solid, gas) The product is not flammable. - Flammability (solids)

Chemical Book 5
Upper/lower flammability or explosive No data available
limits
Vapour pressure 1 hPa at 51 °C
Vapour density 5,64 - (Air = 1.0)
Relative density No data available
Water solubility 81,7 g/l at 20 °C - completely soluble
Partition coefficient: n-octanol/water log Pow: 1,33 - Bioaccumulation is not expected.
Autoignition temperature does not ignite
Decomposition temperature No data available
Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available
Explosive properties No data available
Oxidizing properties No data available
λmax 210nm(EtOH)(lit.)

Other safety information

Surface tension 27,8 mN/m at 80,2 °C

Relative vapor density

5,64 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust
explosion potential may generally be assumed.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Risk of explosion with:

silver salt
Exothermic reaction with:
alkalines
alkali hydroxides Amines
Strong oxidizing agents sulfoxides
dimethyl sulfoxide with
Copper

Conditions to avoid

Exposure to moisture. Heat. no information available

Incompatible materials
Chemical Book 6
Metals

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
LD50 Oral - Rat - 3.320 mg/kg Remarks: (IUCLID) Inhalation
Skin corrosion/irritation
Skin - Rabbit Result: Corrosive Remarks: (IUCLID)
Serious eye damage/eye irritation
Causes serious eye damage.
Respiratory or skin sensitization
Remarks: (IUCLID)
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: positive
Test Type: In vitro mammalian cell gene mutation test Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: Positive results were obtained in some in vitro tests.
Test Type: In vivo micronucleus test Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal injection Method: OECD Test Guideline 474
Result: negative
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
May cause respiratory irritation. - Respiratory system
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Toxicity
LD50 orally in rats: 5000 mg/kg (Bailey, White)

Chemical Book 7
SECTION 12: Ecological information

Toxicity

No data available

Persistence and degradability

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and
very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and

containers, or contact us there if you have further questions.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause
fires or explosions. Keep away from alkaline materials, silver salts, strong acids, strong bases, moisture, iron, zinc, aluminum. Corrosive to
iron, steel and other metals.

SECTION 14: Transport information

UN number

ADR/RID: 1839 IMDG: 1839 IATA: 1839

UN proper shipping name

ADR/RID: TRICHLOROACETIC ACID

IMDG: TRICHLOROACETIC ACID, SOLID

Chemical Book 8
IATA: Trichloroacetic acid

Transport hazard class(es)

ADR/RID: 8 IMDG: 8 IATA: 8

Packaging group

ADR/RID: II IMDG: II IATA: II

Environmental hazards

ADR/RID: yes IMDG Marine pollutant: yes IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/
EC Inventory:Listed.
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

Chemical Book 9
References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:

http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest
and medical observation is therefore essential.Immediate administration of an appropriate inhalation therapy by a doctor or a person
authorized by him/her, should be considered.

Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of
this product and other substances. This MSDS only provides information on the safety of the product for those who have received the
appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability
of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

Chemical Book 10