Synopsis Rguhs

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA
BANGALORE
ANNEXURE II
PERFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

1. NAME AND ADDRESS OF DR. KESHAVAMURTHY ADDYA
THE CANDIDATE ROOM # 320, SVBL
DHARMASHALA, VICTORIA
HOSPITAL BANGALORE-560002.
2. NAME OF THE INSTITUTION BANGALORE MEDICAL

COLLEGE AND RESEARCH
INSTITUTE, BANGALORE –
560002
3. COURSE OF STUDY AND M.D. IN DERMATOLOGY,

SUBJECT VENEROLOGY AND LEPROSY.
4. DATE OF ADMISSION TO 31 – 05 – 2007.

COURSE
5. TITLE OF TOPIC STUDY OF CLINICAL AND

WOOD’S LAMP PATTERN OF
MELASMA IN MALES AND
ASSOCIATED HORMONAL
PROFILE.
6. BRIEF RESUME OF THE INTENDED WORK:
6.1. NEED FOR THE STUDY
Melasma is a common problem of facial hyperpigmentation,

commonly affecting women than men. Though present in both sexes, most of the
studies have been done in females. This study is therefore undertaken to evaluate
clinical and Wood’s lamp patern and hormonal profile in men with melasma.
6.2. REVIEW OF LITERATURE
Melasma is a common acquired symmetric hypermelanosis

characterised by irregular light to gray-brown macules and patches involving sun
exposed areas of the skin1. Those most affected are women2. Multiple factors have
been postulated to involve in the etiology and pathogenesis of melasma including
pregnancy, oral contraceptives, genetic influences, endocrine disturbances, exposure
to UV radiation, cosmetics, phototoxic drugs, anti-seizure medications and race1, 2, 3, 4.
Three patterns of melasma are recognised clinically 1) Centro-facial 2) Malar, and 3)
Mandibular pattern4. Examination of patients with wood’s light (320 – 400nm) is
useful in classifying the specific type of melasma in correlation with the localisation
of pigment granules (melanosomes) in the epidermis and dermis4. Four types of
melasma are described on the basis of wood’s light examination: 1) an epidermal type
2) a dermal type 3) a mixed type, and 4) a fourth type, described in patients of dark
complexion4.
Treatment of melasma involves the use of a range of topical
depigmenting agents and physical therapies5. Use of broad spectrum (UVA+UVB) is
important, as is topical hydroquinone, the most common treatment for melasma6.
Other lightening agents include retinoic acid (tretinoin), azelaic acid6. chemical peels,
laser treatments and intense pulsed light therapy are additional therapeutic modalities
that have been used to treat melasma6.
6.3. OBJECTIVES OF THE STUDY
To evaluate clinical, Wood’s lamp and hormonal patterns associated

with melasma in men.
7. MATERIALS AND METHODS:
7.1 SOURCE OF DATA
Male patients attending the Dermatology OPD in hospitals attached to

Bangalore Medical College, Bangalore.
7.2 METHOD OF COLLECTION OF DATA
One hundred men with characteristic clinical lesions of melasma will be

considred for the study. Written consent will be taken before participation of the
patients into the study. A short questionnaire will record the name of person, age,
address, marital status and occupation. After detailed history taking, with access on
various factors such as drug history, seasonal variation, family history, cosmetic
application, sunlight exposure, age of onset and duration, Wood’s lamp examination
and melasma area and severity index (MASI) calculation will be done. Complete
general physical examination, systemic examination and complete dermatologic
examination will also be carried out.
INCLUSION CRITERIA
All male patients with characteristic clinical features of melasma

attending Dermatology OPD at hospitals attached to Bangalore Medical College,
Bangalore.
EXCLUSION CRITERIA
1) Male patients with other hypermelanotic disorders.

2) Females with melasma.
7.3 Does the study require any investigations or interventions to be
conducted on patients or other humans or animals? If so, please
describe briefly.
Yes, the study requires Wood’s lamp examination of the lesions for
classification and serum TSH, FSH and LH assay to see if any hormonal imbalance is
associated.
7.4 Has the ethical clearance been obtained from your institution in
case of 7.3?
Yes.
8. LIST OF REFERENCES
1. Grimes PE; Melasma. Etiologic and therapeutic considerations. Arch

Dermatol 1995 Dec; 131(12):1453-7.
2. Kauh YC, Zachain TF. Melasma. Adv Exp Med Biol. 1999;455:491-
9.
3. Victor FC, Gelber J, Rao B. Melasma: a review. J Cutan Med Surg.
2004 Mar-Apr; 8(2):97-102.
4. Sanchez NP, Pathak MA, Sato S, Fitzpatrick TB, Sanchez JL, Mihm
MC Jr. Melasma: a clinical, light microscopic, ultrastructural and
immunofluoroscence study. J Am Acad Dermatol. 1981 Jun; 4(6): 698-710.
5. Rendon M, Berneburg M, Arellano I, Picardo M. Treatment of
melasma. J Am Acad Dermatol. 2006 May; 54(5 suppl 2): S272-81.
6. Gupta AK, Gover MD, Nouri K, Taylor S. The treatment of melasma:
a review of clinical trials. J Am Acad Dermatol. 2006 Dec; 55(6): 1048-65.
9. SIGNATURE OF THE CANDIDATE:
10. REMARKS OF THE GUIDE:

Although there is a significant female
preponderance of melasma, its incidence in
males is around 10%. Since pregnancy and
oral contraceptive use which account for the
major etiologic factors in females, are not
associated with men. Hence there is a need to
explore various factors that are involved in
etiopathogenesis and clinical variations of
melasma in men as against in women.
11.1. NAME AND DESIGNATION OF THE GUIDE:
DR. Y. N. SACCHIDANAND
PROFESSOR,
DEPT. OF DERMATOLOGY,
VENEREOLOGY AND LEPROLOGY
BANGALORE MEDICAL COLLEGE
BOWRING AND LADY CURZON
HOSPITAL
BANGALORE-01.
11.2. SIGNATURE:
11.3. COGUIDE:
11.4. SIGNATURE:
11.5. HEAD OF THE DEPARTMENT:
DR. H.V. NATRAJ

PROFESSOR AND H.O.D
DEPT. OF DERMATOLOGY,
VENEREOLOGY AND LEPROLOGY
BANGALORE MEDICAL COLLEGE
VICTORIA HOSPITAL
BANGALORE-02.
11.6. SIGNATURE:
12.1. REMARKS OF THE CHAIRMAN AND PRINCIPAL:
12.2. SIGNATURE OF THE PRINCIPAL:

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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA

PERFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

2. NAME OF THE INSTITUTION BANGALORE MEDICAL

3. COURSE OF STUDY AND M.D. IN DERMATOLOGY,

4. DATE OF ADMISSION TO 31 – 05 – 2007.

5. TITLE OF TOPIC STUDY OF CLINICAL AND

6.1. NEED FOR THE STUDY

Melasma is a common problem of facial hyperpigmentation,

6.2. REVIEW OF LITERATURE

Melasma is a common acquired symmetric hypermelanosis

To evaluate clinical, Wood’s lamp and hormonal patterns associated

7. MATERIALS AND METHODS:

7.1 SOURCE OF DATA

Male patients attending the Dermatology OPD in hospitals attached to

7.2 METHOD OF COLLECTION OF DATA

One hundred men with characteristic clinical lesions of melasma will be

All male patients with characteristic clinical features of melasma

1) Male patients with other hypermelanotic disorders.

1. Grimes PE; Melasma. Etiologic and therapeutic considerations. Arch

10. REMARKS OF THE GUIDE:

11.1. NAME AND DESIGNATION OF THE GUIDE:

11.5. HEAD OF THE DEPARTMENT:

DR. H.V. NATRAJ

12.1. REMARKS OF THE CHAIRMAN AND PRINCIPAL:

12.2. SIGNATURE OF THE PRINCIPAL:

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