68 Vishalp
68 Vishalp
68 Vishalp
Date : Sep 18, 2023 Sample Coll. : 10:53 Sep 18, 2023
Ref. No. : 2309-18068 Report Time : 12:09 Sep 18, 2023
Patient : Mr. Vishal Pandey 26 Y / M
Ref. Doctor : SELF Delivery : Counter
*18068*
HEMATOLOGY†
Investigation Result Units Bio. Reference Interval
D L C, W. Blood
Polymorphs : 74 % 45 - 74
Lymphocytes : 23 % 16 - 45
Eosinophils : 2 % 0-5
Monocytes : 1 % 0-5
Method- DC Detection
Date : Sep 18, 2023 Sample Coll. : 10:53 Sep 18, 2023
Ref. No. : 2309-18068 Report Time : 12:09 Sep 18, 2023
Patient : Mr. Vishal Pandey 26 Y / M
Ref. Doctor : SELF Delivery : Counter
*18068*
SEROLOGY & IMMUNOLOGY
Investigation Result Units Bio. Reference Interval
Interpretation:
Index of Patient/ Cut-off >=1.0 - NS1 Detected
Index of Patient/ Cut-off < 1.0 - Not Detected
Dengue virus (DENV) belongs to the Flaviviridae family and is transmitted to humans by Aedes mosquitoes. DENV are divided into four
serotypes: DEN-1, DEN-2, DEN-3 and DEN-4. Clinical diagnosis of DENV infection mainly relies on nonspecific symptoms (headache,
arthralgia, myalgia, nausea, vomiting, and thrombocytopenia). Laboratory diagnosis relying on direct and/or indirect methods is used to
confirm dengue diagnosis.
During the early phase (less than 5-7 days after onset), direct diagnostic techniques, such as the identification of viral nucleic acid or NS1
antigen, are preferred. Combining NS1 detection with IgM serological assay in routine diagnosis of DENV infection can help to improve
accuracy of dengue diagnosis.4-7 After 5-7 days, serological tests, based on host immune response to virus infection (IgM and/or IgG), are
commonly used. The timing of the appearance and duration of these biomarkers depend on whether the patient is experiencing a primary or
secondary DENV infection. During primary infection, the antibody response to DENV infection with IgM is usually detectable early after the
onset of the symptoms and persists for 2-3 months; dengue IgG appear few days after IgM and persist for years. During secondary
infection, dengue IgG appear earlier and IgM have kinetics close to primary infection but at a lower level.
- The above test is a sensitive Rapid ELISA antibody detection test from PANBIO ELISA, Australia (Reagent kit endorsed in Indian Journal of
Pathology[1]). The kit is sensitive and specific to both IgG and IgM antibodies directed against Dengue arbovirus.
A reactive result for IgM antibodies indicates presence of circulationg anti-Dengue antibodies of IgM class (acute/primary infection by one of
the serotypes of dengue arbovirus). Similarly a reactive result for IgG antibodies indicates presence of circulationg anti-Dengue antibodies
of IgG class.
1- Baruah J, Shiv Ananda, Arun Kumar G . Incidence of dengue in a tertiary care centre- Kasturba Hospital,Manipal. Indian J Pathol
Microbiol; 49(3):462-463 Quote-` The study found Fever, headache and myalgia in nearly all IgM postive cases while rash and petechiae in
7% and 9% cases respectiely.`
--End of Report--
CBC only*,DengGM_NS1*