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    1. Phenol is a colorless to pink crystalline solid or viscous liquid with a distinct odor. It is corrosive and causes severe tissue damage through direct contact with skin or eyes. Vapors are highly irritating. 2. Tests on phenol showed the expected color changes, including blue with hypochlorite, white precipitate with bromine water, and red with ferric chloride, confirming the presence of phenol. 3. Phenol is toxic through multiple routes of absorption including skin, inhalation, ingestion, and mucous membranes. It disrupts proteins, cell membranes and causes organ damage. Activated charcoal is the specific antidote by absorbing phen

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    VESTIL-PHENOL

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    1. Phenol is a colorless to pink crystalline solid or viscous liquid with a distinct odor. It is corrosive and causes severe tissue damage through direct contact with skin or eyes. Vapors are highly irritating. 2. Tests on phenol showed the expected color changes, including blue with hypochlorite, white precipitate with bromine water, and red with ferric chloride, confirming the presence of phenol. 3. Phenol is toxic through multiple routes of absorption including skin, inhalation, ingestion, and mucous membranes. It disrupts proteins, cell membranes and causes organ damage. Activated charcoal is the specific antidote by absorbing phen

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    5 views3 pages

    Vestil Phenol

    Uploaded by

    ninachristenevestil25
    1. Phenol is a colorless to pink crystalline solid or viscous liquid with a distinct odor. It is corrosive and causes severe tissue damage through direct contact with skin or eyes. Vapors are highly irritating. 2. Tests on phenol showed the expected color changes, including blue with hypochlorite, white precipitate with bromine water, and red with ferric chloride, confirming the presence of phenol. 3. Phenol is toxic through multiple routes of absorption including skin, inhalation, ingestion, and mucous membranes. It disrupts proteins, cell membranes and causes organ damage. Activated charcoal is the specific antidote by absorbing phen

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    of 3

    Vestil, Niña Christene BSPH-3 Toxicology.

    Lab

    Experiment # 4
    Phenol

    Phenol (carbolic acid, hydroxybenzene) is a colorless to pink crystalline solid, or viscous


    liquid It has a distinct, acrid, and aromatic odor or as being sweet and tarry. It is a corrosive acid and
    protein denaturant. Direct eye or skin contact causes severe tissue damage or blindness. Deep skin
    bums can occur without warning pain. Systemic toxicity by all routes; percutaneous absorption of
    vapors occurs. Vapors are highly irritating to eyes and respiratory tract.

    Hexachlorophene is a chlorinated biphenol that was widely used as a topical antiseptic and
    preoperative scrub until its adverse neurologic effects were recognized. Other phenolic compounds
    include creosote, creosol, hydroquinone, eugenol, and phenylphenol (biphenol, the active ingredient
    in Lysol).

    Materials
    Test tube with rack Dropper
    Graduated cylinder Beaker (100 mL x 2 pcs)
    Test tube brush Test tube holder
    Bunsen burner Water bath

    Chemicals
    Phenol solution (carbolic acid solution) Ferric chloride 10% solution
    Ammonium hydroxide solution Calcium or Na hypochlorite solution
    Cone. Sulphuric acid Potassium hydroxide
    Potassium permanganate solution

    Procedures
    1. Hypochlorite test:
    Add a few ammonium hydroxide solution to a dilute aqueous carbolic solution and 2 to 3
    drops of freshly prepared calcium or sodium hypochlorite solution. Heat gently and take note
    of the color. Very dilute solutions of carbolic acid after some time give only a green color.
    lbis test is also known as Dex's reaction.

    2. Bromine water test:


    Add excess of bromine water to a very little amount of carbolic acid.

    3. Millon's test:
    Vestil, Niña Christene BSPH-3 Toxicology.Lab

    Heat Millon's reagent with solution containing only a trace of carbolic acid
    and note the color.

    4. Ferric chloride test:


    From 3 mL of phenol solution, add I or 2 drops of ferric chloride. Take
    note of the color fonned.

    s. Reduction test:
    Add a few drops of phenol to 3 mL of potassium permanganate solution
    and observe the color change.
    Results:
    Test Actual result Theoretical result Compound present
    Ammonia & sodium
    Hypochlorite test Blue color
    hypochlorite

    White precipitate
    Bromine water test 2,4,6 tribromophenol
    Smell: antiseptic
    - ..

    Millon's test Red colored precipitate

    Red, blue, green or purple


    Ferric chloride test Phenol
    color

    Reduction test Pale pink or colorless

    Questions:

    1. Give the mechanism of toxicity of phenol.


    • Harms Tissues: Phenol is corrosive, meaning it can damage tissues it
    encounters, like skin, eyes, and mucous membranes. It does this by
    disrupting proteins and cell membranes.

    • Systemic Effects: If phenol gets into the body, it can spread and cause harm
    to organs and systems. It disrupts cellular functions by damaging proteins,
    and cell membranes, and causing oxidative stress.

    • Organ Damage: Phenol can harm organs like the liver, kidneys, respiratory
    Vestil, Niña Christene BSPH-3 Toxicology.Lab

    system, and central nervous system. This damage can result in various
    symptoms and complications.
    • Metabolic Activation: In the liver, phenol can be turned into reactive
    chemicals that can cause further damage to cells and tissues.

    2. What is the specific antidote for phenol poisoning?

    The specific antidote for phenol poisoning is activated charcoal. Activated


    charcoal can help absorb phenol in the stomach and prevent it from being absorbed
    into the bloodstream.
    It's often given alongside other supportive treatments like fluids and
    medications to manage symptoms.

    3. What are the routes of absorption of Phenol?


    Phenol can be absorbed through various routes:
    1. Skin: Direct contact with the skin can lead to absorption.
    2. Inhalation: Breathing in phenol vapors can lead to absorption through the
    lungs.
    3. Ingestion: Swallowing phenol-containing substances can lead to absorption
    through the digestive tract.
    4. Mucous Membranes: Phenol can be absorbed through the mucous
    membranes of the eyes, nose, and mouth.

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