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    Postbiotics - What's New - Gabriel Vinderola

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    Nguyen Minh Chau
    This document summarizes a presentation on postbiotics by Gabriel Vinderola. It discusses the ISAPP definition of postbiotics as preparations from inactivated microorganisms that confer health benefits. It notes challenges in categorizing products containing non-viable microbes and the potential contributions of dead cells to probiotic effects. Promising research on postbiotics for skin conditions and applications where viable bacteria cannot be used is mentioned. The conclusion emphasizes that the postbiotic concept remains an active area of research and regulation.

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    Postbiotics - What's New - Gabriel Vinderola

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    Nguyen Minh Chau
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    This document summarizes a presentation on postbiotics by Gabriel Vinderola. It discusses the ISAPP definition of postbiotics as preparations from inactivated microorganisms that confer health benefits. It notes challenges in categorizing products containing non-viable microbes and the potential contributions of dead cells to probiotic effects. Promising research on postbiotics for skin conditions and applications where viable bacteria cannot be used is mentioned. The conclusion emphasizes that the postbiotic concept remains an active area of research and regulation.

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    This document summarizes a presentation on postbiotics by Gabriel Vinderola. It discusses the ISAPP definition of postbiotics as preparations from inactivated microorganisms that confer health benefits. It notes challenges in categorizing products containing non-viable microbes and the potential contributions of dead cells to probiotic effects. Promising research on postbiotics for skin conditions and applications where viable bacteria cannot be used is mentioned. The conclusion emphasizes that the postbiotic concept remains an active area of research and regulation.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    17 views24 pages

    Postbiotics - What's New - Gabriel Vinderola

    Uploaded by

    Nguyen Minh Chau
    This document summarizes a presentation on postbiotics by Gabriel Vinderola. It discusses the ISAPP definition of postbiotics as preparations from inactivated microorganisms that confer health benefits. It notes challenges in categorizing products containing non-viable microbes and the potential contributions of dead cells to probiotic effects. Promising research on postbiotics for skin conditions and applications where viable bacteria cannot be used is mentioned. The conclusion emphasizes that the postbiotic concept remains an active area of research and regulation.

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    of 24

    POSTBIOTICS

    What’s new?
    Gabriel Vinderola

    Dairy Products Institute


    1 (INLAIN, UNL-CONICET)
    Faculty of Chemical Engineering
    National University of Litoral
    Santa Fe, Argentina

    gvinde@fiq.unl.edu.ar
    Declaration of COI

    Speaker, advisory boards, product development, quality control for


    companies dedicated to the production of LAB, probiotics, postbiotics,
    fermented foods.

    Board member of the International Scientific Association for Probiotics


    and Prebiotics (ISAPP)
    THE ISAPP DEFINITION: MORE THAN 17 WORDS
    derived from “biotic”: relating to or resulting from the matrix and/or the
    living organisms”, “post”: refers to after: after life. inactivation method may play a
    role in the effect

    Postbiotic: “a preparation of inanimate microorganisms and/or


    their components that confers a health benefit on the host.
    the demonstration of the health
    benefit is required by a clinical
    including cell fragments, trial on the target host
    metabolites can be present or not
    rather than ‘dead’ or ‘inactive’,
    since these latter terms may
    suggest an inert material.
    Frequently asked questions about the ISAPP postbiotic definition. Vinderola G, Sanders ME, Cunningham M, Hill C. Frontiers in Microbiology 2024.
    Frequently asked questions about the ISAPP postbiotic definition. Vinderola G, Sanders ME, Cunningham M, Hill C. Frontiers in Microbiology 2024.
    THE IMPACT OF THE
    ISAPP’S DEFINITION
    PRESENTATION OUTLINE
    Health Canada is considering the term postbiotics
    8

    Brian McNeill, officer Health Canada


    PRESENTATION OUTLINE
    American College of Gastroenterology
    9

    The American Journal of Gastroenterology


    January 2024 - Volume 119 - 1S

    9
    PRESENTATION OUTLINE
    The China Institute of Food and Drug Control
    10

    10
    CHALLENGES TO THE CATEGORY
    OF PRODUCTS CONTAINING
    NON-VIABLE MICROBES
    THE FUTURE
    THE CONTRIBUTION OF DEAD CELLS TO THE PROBIOTIC EFFECTS WE
    KNOW SO FAR MAY BE MORE RELEVANT THAN WHAT WE THINK

    When the amount of dead cells after freeze-drying is combined with the amount of dead cells after
    storage (overfilling), a probiotic product may contain more dead than live cells
    SOME STRAINS CAN BE EFFECTIVE AS PROBIOTIC
    OR AS A POSTBIOTIC
    Guglielmetti S, Mora D, Gschwender M, Popp K. Randomised clinical trial:
    Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome
    and improves quality of life--a double-blind, placebo-controlled study. Aliment
    Pharmacol Ther. 2011 May;33(10):1123-32.

    Andresen V, Gschossmann J, Layer P. Heat-inactivated Bifidobacterium bifidum


    MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre,
    randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol
    Hepatol. 2020 Jul;5(7):658-666.

    But remember a postbiotic is not a dead probiotic!


    ANIMAL STUDIES ARE PROMISING
    APPLICATIONS NOT SUITABLE FOR VIABLE BACTERIA
    APPLICATIONS NOT SUITABLE FOR VIABLE BACTERIA
    POSTBIOTICS FOR SKIN CONDITIONS
    WORK IN PROGRESS IN ARGENTINA
    Postbiotics from human-milk derived Bifidobacterium lactis INL1 and L. plantarum 73ª, for atopic
    dermatitis
    TNF IL-6
    17500 4000

    Concentration (pg/mL)
    Concentration (pg/mL)

    15000

    12500 3000

    10000
    2000
    7500

    5000
    1000
    2500

    0 0
    C CLPS B S B+S B S B+S B S B+S CLPS B S B+S B S B+S B S B+S
    INL 73a MIX INL 73a MIX
    LPS
    23

    CONCLUDING REMARKS
    ✓The definition is an extreme simplification (17 words) of a complex
    concept, described in a paper of more than 9000 words.
    ✓Some leading countries (Canada, China, Hong Kong) started
    considering the ISAPP definition to regulate the concept.
    ✓The unregarded contribution of dead cells in probiotic products may
    be very promising to postbiotics.
    ✓Challenge: to develop validated tools to quantify postbiotics.
    23

    ✓An ISAPP working Group on the topic will take place this year.
    Thank you! Gracias!
    Gabriel Vinderola

    Dairy Products Institute


    24 (INLAIN, UNL-CONICET)
    Faculty of Chemical Engineering
    National University of Litoral
    Santa Fe, Argentina

    gvinde@fiq.unl.edu.ar

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