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Review Article Open Access

A Review on Aspergillosis in Poultry

Genene Girma1, Mengestie Abebaw1, Mebrie Zemene1*, Yergashewa Mamuye1 and Gashaw Getaneh2
1
Faculty of Veterinary Medicine, Department of Veterinary Pharmacy, University of Gondar, Gondar, Ethiopia
2
Faculty of Veterinary Medicine, Department of Biomedical Science, University of Gondar, Gondar, Ethiopia

Abstract
Aspergillosis is a respiratory disease of chicken, turkey, humans and other mammals and less frequently ducks,
pigeon, geese and other wild and domestic birds. It is cuased by a fungal species under the genus Aspergillus. In
chickens and turkey, the disease may be endemic on some farm. In wild birds, it appears too sporadic, frequently
affecting only an individual bird. It is usually seen in birds of 7-40 days old. Aspergillus spp are ubiquitous and the
disease is found where ever environmental condition is favorable for growth. Aspergillus fumigatus is frequently
isolated in affected bird. Infection occurs by inhalation of spores. The disease has two forms, acute and chronic form.
The acute form occurs when large amount of spores are ingested by the bird, where as, the chronic form affects birds
under immune suppression. The clinical signs are non-specific and a variety of diagnostic procedures are required
for the diagnosis of aspergillosis in poultry, of which culturing is very important. Treatment of aspergillosis is not
effective and prevention is the best way of controlling the disease. Good managemental practices such as sanitation,
avoiding wet litter or soil and moldy or dusty feeds, provididing adequate ventilation, and disinfecting feed and water
lines should be implemented to prevent and control the disease.

Keywords: Aspergillosis; Aspergillus fumigatus; Pevenetion found in Aspergillus nidulans that can be reproduced by ascospores.
When grow start hyphae, together forming mycelia. Vegetative mycelia
Introduction consists of superficial hyphae and hyphae on the surface are aerial
Aspergillosis is non-contagious disease of avian. It is cuased mycelia. This structure produce conidiophore, these are formed in foot
by a fungal species under the genus Aspergillus. The disease occurs cells and end in a vesicle, in this stricter grow one line of phyalides
under immune compromised situations of the host or when the bird or one line of mutulae and over this stricter one line of phyalides
is exposed to an overwhelming number of spores. Stress is the main that produce a chain of conidia or spores. Conidia are uni or multi
predisposing factor for the development of the disease [1]. It is a nucleated but always single celled [6].
common mismanagement problem in commercial and back yard
poultry. The disease primarily affects lower respiratory system [2]. The function of the conidia is dissemination of the fungus.
Aspergillus is useable as a food in many different substances because of
Aspergillus spp can penetrate egg shell and infect the embryo. the number of enzyme that it can produce. The two main requirement
The infected embryo may die or hatch with well developed lesion. If
of substance for fungal growth are organic matter and moisture, if both
infected eggs are broken, large numbers of spores are released, which
contaminate the hatchery equipment [3]. Aspergillosis can be acute or factors are present the fungus can grow in almost any substance. The
chronic form. Acute aspergillosis generally occurs in young birds and shape can be globose, elliptical or oval, and the surface can be smooth or
resulting in high morbidity and mortality. The chronic form is sporadic finely rough. The color of conidia determines the color of the conidial
and it causes lesser mortality and generally affects older birds, especially head which also determine the color of the colony [7].
a compromised immune system due to poor husbandry condition [2].
Kingdom Fungi
Poor sanitation in the house as well as food contamination promotes
Division Ascomycota
fungal growth. Poor ventilation in conjunction with these factor increase
Class Eurotiomycetes
the possibility of invassion and infection of birds’ respiratory system by air
Order Eurotiales
borne spore [2]. Mycotoxins are toxic secondary metabolites produced by
Family Trichocomaceae
organisms of the fungus. Aflatoxin is a type of mycotoxins produced by
Genus Aspergillus
Aspergillus flavus and Aspergillus parasiticus and ochratoxin is produced by
Aspergillus ochraecus that affect poultry when they consume contaminated Source: [5]
food [4-6]. Therefore, the objectives of this paper are to highlight about Table 1: Taxonomy of Aspergillus.
poultry Aspergillosis (Table 1).

Etiology *Corresponding author: Mebrie Zemene, Lecturer, Faculty of Veterinary Medicine,

Department of Veterinary Pharmacy, University of Gondar, Gondar, Ethiopia, Tel:
Aspergillosis in poultry is cuased by a fungal species under 251918518866; E-mail: zemenemebrie@gmail.com
the genus Aspergillus. Organisms cultured from affected organ in Received July 12, 2016; Accepted August 31, 2016; Published September 05,
decreasing frequency are: Aspergillus fumigates, A. flavus, A. niger, A. 2016
glaucus and A. terreus. From these spp, A. fumigatus is a common cause Citation: Girma G, Abebaw M, Zemene M, Mamuye Y, Getaneh G (2016) A
of the disease. These organisms are common soil saprophytes which Review on Aspergillosis in Poultry. J Vet Sci Technol 7: 382. doi: 10.4172/2157-
grow on organic matter in warm (>25°C) and also humid environment, 7579.1000382
and damaged egg in hatchery [7,8]. Copyright: © 2016 Girma G, et al. This is an open-access article distributed under
the terms of the Creative Commons Attribution License, which permits unrestricted
Most of the species under the genus Aspergillus are classified as use, distribution, and reproduction in any medium, provided the original author and
fungi imperfect (asexual reproduction) but the perfect state has been source are credited.

J Vet Sci Technol, an open access journal

ISSN: 2157-7579 Volume 7 • Issue 6 • 1000382
Citation: Girma G, Abebaw M, Zemene M, Mamuye Y, Getaneh G (2016) A Review on Aspergillosis in Poultry. J Vet Sci Technol 7: 382. doi:
10.4172/2157-7579.1000382

Page 2 of 5

Epidemiology Clinical sign

Aspergillus spp are ubiquitous and the disease has a worldwide Aspergillosis may involve many body systems; fungal spores most
distribution and may be found whereever environmental condition commonly invade trachea, air sacs and lung. Signs depend on the
is favorable for fungal growth. These organisms are common soil number of spore that enter the body and organ system affected but can
saprophytes and grow on organic matter in warm (>25°C) humid be generally reflected as disease of respiratory tract, occasionally the
environments including damaged egg in hatcheries and poor ventilation CNS [7]. There are three common presentation of the disease; diffuse
system. The disease more frequently occurs in tropical countries like lower respiratory tract diseases, syringeal graunloma and focal CNS
Ethiopia. Sever outbreak associated with hatchery contamination may graunuloma particularly in the brain [13].
result in up to 15% chicken mortality during the first two weeks and Within the first 3-5 days newly hatched chicken infected in the
decrease growth rate on affected survivors [2]. hatchery show a very rapid and difficult breathing and start breathing
Concerning the distribution of Aspergillosis among different with an open mouth (gaspers) due to the gradual obstruction of the air
seasons, [8] reported that the disease is prevailing throughout passage [14]. Survivor may become dull and stunted, show sleepiness,
the year but in hot and humid weather condition, the percentage lack of appetite, emaciation, increased thirst, develop eye swelling or
of positive isolates in both lung and environmental samples was blindness and show torticolis (twisting of the neck to one side). Other
higher in summer (50% and 41.2%) respectively, followed by winter birds may remain subclinically affected for some times but later slowly
season which was (29.2% and 29.4%) respectively as compared with develop breathing problems. This is because increasing body weight
other seasons of the year. These are because of the warm, humid put demands on the reduced functional capacity of the lung [15].
environment and the disease in winter season is common when Infected poultry usually show mortality in two phases: Acute
indoor gas levels tend to be highest. respiratory disease may cause 5-50% mortality in the first 1-3 weeks
of age. Those which survive usually develop chronic disease with up
Transmision and predisposing factors to 5% mortality due to pulmonary insufficiency, ascitis, blindness
Aspergillosis affects avian spp, other animals and humans. All or neurological fungal metastasis. A common feature of dyspnea
birds are susceptible to aspergillosis. It is reported in domestic birds associated with aspergillosis is the lack of respiratory noise [15] (Figure 1).
like poultry, duck, and quails as well as in wild bird [2]. Inhalation Necropsy finding
of conidia or spores from contaminated feed, fecal material, soil and
contamination of egg in ovo, infect the developing embryo. Higher The primary location of lesions is the lungs and air sacs although
susceptibility of birds to aspergillosis may be attributed to anatomic other organs may be involved. Extensive involvement of the respiratory
and physiologic characteristics of the avian respiratory system. The tract can occur before development of clinical signs. Lesions vary in
small non-expanding lungs and nine air sacs constitute a primary size from pinhead or miller seed (milliary <1 mm in diameter) white
nidus for infection because the air (or conidia) reaches the caudal to yellowish granulomas up to the size of a pea. Roughly spherical
air sacs before it pass through those part of the lungs in which the granulomatous nodules (>2 cm) may also be observed in serosa and
gas exchange takes place [9]. Higher body temperature also allows parenchyma of the other organs involved [16].
quick fungal growth. Other factors include chronic stress, unsanitary Pulmonary lesions are characterized by multiple hard creams
conditions, overcrowding, malnutrition, vitamin deficiencies especially to yellow colored, circumscribe plaques a few mm to several cm in
vitamin A and overuse of certain medications (corticosteroids) as well diameter seen throughout the lungs surface, inside the lungs, scattered
as respiratory irritants (disinfectant fumes and aerosol sprays). Birds in ventral surface of sternum and air passages on gross examination
that are otherwise ill or are very young or old are also susceptible (Figures 2a and 2b). The plaques also found in the syrinx, air sacs,
to aspergillosis [10]. The incidence of aspergillosis increased when
chicken reared on saw dust than rice husk as litter and incidence was
67.74% and 32.26% respectively might be due to high moisture content
of saw dust allowing more fungal growth than rice husk [11].
Pathogenesis
Aspergillosis is caused by inhalation of overwhelming numbers
of small, hydrophobic fungal spores (conidia) into the respiratory
tract. After infective spores invade tracheal, nasal, bronchial and air
sac epithelium, they penetrate the respiratory tissue and reproduce
by single division of tubular hyphae to form mycelia and they initiate
granulomas at this site. Then they are disseminated hematogeneously
to the other tissue like brain, pericardium, bone marrow, kidney and
other soft tissue. Tissue invasion creates an inflammatory condition
and inflammatory response with hetrophils, lymphocytes, monocytes
and some giant cells infiltrating the lesion and produce lesion [12].
Chronic disease especially in turkey often terminate in impendence
of pulmonary blood flow caused by enlarging pulmonary granulomas
and this cause right ventricular dilatation and ascitis. Another
mortality cause for aspergillosis included exudates to become lodged
in the trachea or syrinx producing acute respiratory embarrassment in
Figure 1: Structure of Aspergillus [5].
chronically infected individuals [13].

J Vet Sci Technol, an open access journal

ISSN: 2157-7579 Volume 7 • Issue 6 • 1000382
Citation: Girma G, Abebaw M, Zemene M, Mamuye Y, Getaneh G (2016) A Review on Aspergillosis in Poultry. J Vet Sci Technol 7: 382. doi:
10.4172/2157-7579.1000382

Page 3 of 5

debilitating, voice change or exercise intolerance [24]. Granulomatous

nodules and /or cheesy plaques on the serosa and parenchyma of
respiratory tracts as well as other organs are observed. But, definitive
diagnosis is based on the isolation of Aspergillus species by culture or
by the detection of the organism during histological examination [25].
Identification can also be made by preparing a wet smear. For this, a
nodule can be dissected out and crushed on a slide beneath a cover slip
in a drop of 20% potassium hydroxide and lactophenol cotton blue.
The lactophenol cotton blue stains the fungal hyphae. Wet mounts can
also be prepared from sputum or nasal swabs in either 10% KOH and
Calcofluor or Parker inkand/or Gram stain [26].
The tissue samples (lungs, trachea, pharynx and thoracic air sacs
as well as other organs) fixed in 10% neutral buffered formalin are
Figure 2: a. Lung shows the presence of cream color nodules in plural surface,
air sacs (arrow). b. Creamy to yellow color nodules shows throughout the lung processed and embedded in paraffin blocks and stain with haematoxylin
(arrow) [11]. and eosin (HE) method. Aspergillus hyphae stained poorly in H and
E stained sections. Differential stains such as Periodic acid-Schiff
liver and intestines. Lung parenchyma wasconsolidated and single or (PAS), Bauer’s and Gridley’s stains differentiate and easily identify the
multiple necrotic areas are visible on cut surfaces of lungs [11]. hyphae and mycelia. Special stains for fungus Grocott’s and Gomori
Methanamine Silver stain should be employed to detect the presence of
Mycotic pododermatitis along with pulmonary aspergillosis was
reported in turkeys. In footpads, keratinized epidermal disruption, fungal hyphae. For proper identification of the species, the pathogenic
encrustations and acute inflammation were noted [17]. Epidermal organism must be isolated by culturing it on differential media. Small
cysts associated with A. fumigatus have been described in the comb pieces of lesions aseptically removed are placed onto plates or slants
of a silky bantam chicken [18]. It leads to periorbital swelling, swollen containing malt agar, Sabouraud’s glucose agar or antibiotics and
and adhered eyelids with turbid discharge, cloudy cornea and cheesy incubated at 37°C for 24 hours. Species of Aspergillus can be identified
yellow exudates within the conjunctival sac [19]. Osteo-arthritis and by observing the characteristic conidial head and colony [16].
granulomatous osteoarthritis of the hip joints with necrosis of the
femur head was observed in turkey [20]. Differential Diagnosis
Visceral organs were involved in aspergillosis with formation of The differential diagnosis includes infectious bronchitis
nodular granulomatous lesions. Right ventricular dilatation or cor (dyspnea), newcastle disease (watery greenish diarrhea), infectious
pulmonale due to pulmonary hypertension may occur with or without larngeo tracheaties (gasping, cough and extension of the neck during
ascites in poultry [21]. Abscesses in the cerebellum and cerebrum were inspiration), dactylaria infection (nervous sign) and nutritional
reported. It may occur with or without pulmonary and other lesions. encephalomalacia [27].
In the cerebellum of broiler breeders and turkeys, circumscribed white
to greyish areas were observed. Granuloma formation was also seen in
the brain and lungs of layer chicken [22].
Histopathology
The microscopical examination showed congestion of pulmonary
and perialveolar blood vessel and perivascular edema (Figure 3).
The normal architecture of the lung and air sacs were replaced by
disseminated granulomatous foci. The center of the granulomatous
foci contained caseous necrosis and necrotic cellular debris surrounded
by rims of heterophils, lymphocytes, macrophages and multinucleated Figure 3: a. Showing congestion of pulmonary, perialveolar blood vessel
giant cells was seen (Figure 3). The nodules consisted of coagulative and diffuse edema of pulmonary tissues (arrow) in Lung. b. Areas of caseous
necrotic center (Figure 4). A few, more severe, densification and necrosis (black arrow) and cellular debris (red arrow) in lung [11].
inflammatory lesions were focally present on the pleura and the
underlying pulmonary lobules (Figure 4) [11].
Diagnosis
Signs of aspergillosis are non-specific and making diagnosis
is difficult. Moreover, no single test provides certainty. Diagnosis
usually relay upon an accumulation of evidence from history, clinical
presentation, postmortem findings, hematology, biochemistry,
serology, radiographic changes, endoscopy, and culture of the fungus.
Cases of aspergillosis in birds are often diagnosed based on postmortem
findings of white caseous nodules in the lungs or air sacs of affected
birds since clinical diagnosis is difficult [23]. The history of the bird can Figure 4: Aspergillosis showing granuloma formation with caseated center
(arrow) in lung. b. Diffuse densification of the pleural parenchyma by congestion
reveal a stressful event and some under lining environmental factors and and an inflammatory cellular infiltration (arrows) in lung [11].
immune suppressive condition or treatment. It may also reveal chronic

J Vet Sci Technol, an open access journal

ISSN: 2157-7579 Volume 7 • Issue 6 • 1000382
Citation: Girma G, Abebaw M, Zemene M, Mamuye Y, Getaneh G (2016) A Review on Aspergillosis in Poultry. J Vet Sci Technol 7: 382. doi:
10.4172/2157-7579.1000382

Page 4 of 5

Treatment with pre-existing asthma who present eosinophlia and intermittent

bronchial obstruction [31-34].
Treatment for Aspergillosis is not effective because the drug used
does not reach the fungus that is walled off by the bird’s inflammatory Conclusion and Recommendations
response and therefore, isolated from the blood stream. This disease
has a poor prognosis when the infection in the tissue is extensive Aspergillosis is a disease of respiratory system of chicken, humans,
and only systemic drugs are used. The best treatment results if the mammals and wild birds and caused by genus Aspergillus, which
granulomatuos lesion is dried and topical treatment in conjunction is distributed worldwide and it is soil saprophyte. It is a common
with systematic therapy is given. Treatment of aspergillosis involves mismanagement problem and causes a high mortality in chicken.
the use of one or more systemic antifungal agent. Drugs which are Environmental factors play an important role in the development of
commonly used include itraconazole, ketoconazole, clotrimazole, the disease include the number of spores to which the bird exposed,
miconazole, fluconazole and Amphotercin B. From these drugs, poor sanitation in the house as well as food contaminated with faces
itraconazole is a choice of treatment of the disease [11]. promote for fungal growth. Poor ventilation in conjunction with other
factor increases the possibility of occurrence of the infection. There is
Prevention and control no effective treatment for the disease.
Aspergillosis has no effective treatment and prevention by Based on the above conclusion, the following recommendations
vaccination is not commercially practicable. Therefore, control are forwarded:
depends on reducing exposure to the fungus and associated risk factors.
• Cleaning and disinfection of feed and water utensils
Aspergillus fumigatus in young chicken has been somewhat controlled
by hatchery sanitation. Moldy litter or feed should be avoided to prevent • Poultry house must be well ventilated.
outbreak of aspergillosis. It is advisable to treat poultry house and litter
with antifungal compounds [28]. Any moldy feed should be removed, • Avoid overcrowding in poultry house.
bulk feed container should be cleaned, old litter should be removed • Avoid moldy or dusty feed.
from house and replaced with new. Hatching equipment and air ducts
should be cleaned, disinfected and well monitored. Contaminated • Proper Sanitation of hatching equipment.
hatchery should be fumigated with formaldehyde or thiabendazole • Treat poultry house and disinfect the litter with antifungal
120-360 g/m3 [13]. compound.
Public Health Significance of Aspergillosis • Cull infected birds to prevent further contamination.
Aspergillosis has a zoonotic importance and recent outbreak of Use mold inhibitor in the feed for suspected outbreak.
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ISSN: 2157-7579 Volume 7 • Issue 6 • 1000382
Citation: Girma G, Abebaw M, Zemene M, Mamuye Y, Getaneh G (2016) A Review on Aspergillosis in Poultry. J Vet Sci Technol 7: 382. doi:
10.4172/2157-7579.1000382

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