Cushing's Syndrome is caused by prolonged exposure to high levels of cortisol in the body. This leads to increased blood pressure through sodium retention, impaired nitric oxide function, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system. It also causes muscle weakness through increased protein breakdown, inhibition of protein synthesis and insulin resistance. It results in weight gain due to stimulation of gluconeogenesis and lipolysis. It can cause kyphosis and osteoporosis by decreasing bone formation and calcium absorption.
Cushing's Syndrome is caused by prolonged exposure to high levels of cortisol in the body. This leads to increased blood pressure through sodium retention, impaired nitric oxide function, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system. It also causes muscle weakness through increased protein breakdown, inhibition of protein synthesis and insulin resistance. It results in weight gain due to stimulation of gluconeogenesis and lipolysis. It can cause kyphosis and osteoporosis by decreasing bone formation and calcium absorption.
Cushing's Syndrome is caused by prolonged exposure to high levels of cortisol in the body. This leads to increased blood pressure through sodium retention, impaired nitric oxide function, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system. It also causes muscle weakness through increased protein breakdown, inhibition of protein synthesis and insulin resistance. It results in weight gain due to stimulation of gluconeogenesis and lipolysis. It can cause kyphosis and osteoporosis by decreasing bone formation and calcium absorption.
Cushing's Syndrome is caused by prolonged exposure to high levels of cortisol in the body. This leads to increased blood pressure through sodium retention, impaired nitric oxide function, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system. It also causes muscle weakness through increased protein breakdown, inhibition of protein synthesis and insulin resistance. It results in weight gain due to stimulation of gluconeogenesis and lipolysis. It can cause kyphosis and osteoporosis by decreasing bone formation and calcium absorption.
Moon Face CUSHING'S SYNDROME DUE TO: Hypersecretion of cortisol by adrenal cortex
2 2 MERCI M- 34 year old woman has a cushing's syndrome disease with complications E- Understand patient's feeling about his career as a teacher and what she feels, ask who is going to be her caregiver and have empathy on how she is going to live with the complications before she is really cured R-Respect the patient and give her the proper treatment, and she has the right to know about all her symptoms caused by the Cushing's syndrome and educate the patient, she also has the right to know the treatment and complications of the treatment and how she is going to take care of herself. C- Communications between doctor and patient are very important so that the information can be delivered effectively, also the communication interprofessionalism between endocrinologist and nurses etc I- How about her financial status, can she afford to undergo the treatment, refer her to the support group so she doesn't feel left out and her mental health after being diagnosed with the disease pathophysiology of cushing's syndrome
related to hypertension Cushing's Syndrome: Disorder due to prolong exposure of cortisol in the body
High level of cortisol
Sodium & fluid Impaired nitric Endothelial
retention oxide function dysfunction
Vascular Activation of changes RAAS system
Hypertension Excess cortisol leads to increase in sodium retention in kidney Sodium & fluid Promotes fluid retention and increases in blood volume retention Increased blood volume can lead to higher blood pressure
Cortisol causes structural changes in blood vessel
Vessels become less flexible and stiff Vascular changes Lead to increased peripheral resistance and high blood pressure
Cortisol can disrupt production and fuction of NO that functions
Impaired Nitric as vasodilator to keep the vessel dilated and regulate BP oxide function Impaired of NO can lead to vasoconstriction, hence higher BP Activation of RAAS Cortisol can stimulate release of Renin, enzyme that can cause system increased production of Angiotensin II, a potent vasoconstrictor Increased in Angiotensin II can lead to more sodium retention, hence contribute to hypertension
High level of cortisol also indirectly disrupts the normal function of
ENdothelial inner lining of blood vessel dysfunction Damaged function of endothelial leads to inflammation, hypertension and vasoconstriction CORTISOL
OVERVIEW ; Steroid produced by the adrenal glands that our bodies needs to deal with physical and emotional stress Maintain energy levels and blood sugar levels High in morning and low at night Secretion increase during stress 1. ANTI INSULIN EFFECT stimulates gluconeogenesis via mobilization of amino acids from tissue protein 3. ANTI-INFLAMMATORY EFFECTS Glycogenolysis Suppression defend mechanism, Reduce glucose utilization in muscles and adipocytes prevent from overactivity Proteolysis Lipolysis
Physiological oction of cortisol
2. ROLE IN STRESS 4. MILD MINERALCORTICOID ACTIVITY Response within a minute pathophysiology of cushing syndrome
related with muscle weakness and
kyphosis PATHOPHYSIOLOGY OF MUSCLE WEAKNESS DUE TO HYPERCORTICOLISM
2022 April 24 increased protein catabolism(proteolysis)
increase the expression and activity of proteolytic
Protein breakdown enzymes, such as the ubiquitin-proteasome system
degrading proteins into smaller peptides and
amino acids.
degrading proteins into smaller peptides and
amino acids.
2 PATHOPHYSIOLOGY OF MUSCLE WEAKNESS DUE TO HYPERCORTICOLISM
2022 April 24 MUSCLE IS MADE OF PROTEIN
CORTISOL WILL INHIBIT PROTEIN SYNTHESIS
Inhibition of protein IT WILL DAMAGE THE RIBOSOME
synthesis IT ALSO INHIBIT IGF-1
2 PATHOPHYSIOLOGY OF MUSCLE WEAKNESS DUE TO HYPERCORTICOLISM
2022 April 24 1. HIGH CORTISOL WILL BIND TO THE LIVER.
2. IT WILL STIMULATE GLUCONEOGENESIS &
INSULIN RESISTANCE GLYCOGENOLYSIS
3. IT CAUSE HIGH LEVEL OF GLUCOSE IN BLOOD
4. CORTISOL SUPRESS THE SECRETION OF INSULIN
5. GLUCOSE UPTAKE IN MUSCLE IS LOW
6. CAUSES MUSCLE WEAKNESS
2 WHAT IS KYPHOSIS
2022 April 24 a spinal condition that causes an exaggerated forward rounding of the upper back. In people with kyphosis, their spine curves outward more than it should, making their upper back look overly rounded. The curvature can make people look hunched or as if they’re slouching 2 PATHOPHYSIOLOGY OF KYPHOSIS DUE TO HYPERCORTICOLISM
2022 April 24 1. maintaining proper alignment and balance.
2. Imbalances in the strength and flexibility of these
MUSCLE WEAKNESS muscles can contribute to kyphosis
3. Weakness or tightness in the muscles of the back,
abdomen, or hips can disrupt the natural spinal
alignment and lead to an increased thoracic curvature.
2 PATHOPHYSIOLOGY OF KYPHOSIS DUE TO HYPERCORTICOLISM
2022 April 24 1. Cortisol stimulates the activity of osteoclasts
DECREASED BONE FORMATION
INCREASED BONE RESORPTION AND 2. Cortisol inhibits the activity of osteoblasts
3. promote an imbalance between bone resorption and
formation, leading to a net loss of bone density over
time.
4. decreased bone formation and remodeling, further
contributing to the loss of bone density.
5. Osteoporosis occur 2 PATHOPHYSIOLOGY OF KYPHOSIS DUE TO HYPERCORTICOLISM
2022 April 24 1. Calcium play important role in bone formation
reduced calcium availability for bone remodeling and
maintenance.
4. Impaired intestinal calcium absorption:
interfere with the absorption of calcium from the intestines
reduces the production and activity of calcitriol that function
2 as enhancing intestinal calcium absorption pathophysiology of cushing syndrome
related with weight gain and
osteoporosis PATHOPHYSIOLOGY OF CUSHING SYNDROME RELATED TO INCREASE BODY WEIGHT PATHOPHYSIOLOGY OF CUSHING SYNDROME RELATED TO OSTEOPOROSIS ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) )
pathophysilogy of cushing syndrome/disease for the signs of bruises/striation and hirsutism
androgen Androgens are a group of male sex hormones that are naturally present in both men and women, but in different responsible for themale secondary sexual amounts. Testosterone characteristic for women is the most well-known androgen.
ainnur DEXAMETHASONE SUPPRESSION TEST anisfarisha 2 5 DEFINITION : Dexamethasone suppression test measures the response of the adrenal glands to ACTH. Dexamethasone is given and levels of cortisol are measured. Cortisol levels should decrease in response to the administration of dexamethasone.
Dexamethasone is sorted like cortisol that block the release of CRH & ACTH from the hypothalamus & anterior pituitary
WHY THE TEST IS DONE?
The low-dose test tell whether your body is producing too much ACTH. (Cushing syndrome)
The high-dose test
anisfarisha help determine where the excess cortisol coming from (Cushing disease) TYPE OF DEXAMETHASONE TEST
