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Pedia Roel

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(Kawasaki Disease)

Abstract

Kawasaki disease is an acute, self-limited vasculitis of unknown etiology that occurs


predominantly in infants and children. If not treated early with high-dose intravenous
immunoglobulin, 1 in 5 children develop coronary artery aneurysms; this risk is reduced 5-fold if
intravenous immunoglobulin is administered within 10 days of fever onset. Coronary artery
aneurysms evolve dynamically over time, usually reaching a peak dimension by 6 weeks after
illness onset. Almost all the morbidity and mortality occur in patients with giant aneurysms. Risk
of myocardial infarction from coronary artery thrombosis is greatest in the first 2 years after
illness onset. However, stenosis and occlusion progress over years. Indeed, Kawasaki disease
is no longer a rare cause of acute coronary syndrome presenting in young adults. Both coronary
artery bypass surgery and percutaneous intervention have been used to treat Kawasaki disease
patients who develop myocardial ischemia as a consequence of coronary artery aneurysms and
stenosis.

Critical Analysis

Diagnosing Kawasaki Disease can be challenging due to its variable presentation and lack of
specific laboratory tests. Early recognition of clinical features such as prolonged fever,
mucocutaneous manifestations, lymphadenopathy, and systemic inflammation is crucial to
initiate timely treatment and prevent coronary artery abnormalities. Intravenous immunoglobulin
(IVIG) and aspirin therapy have been shown to reduce the risk of coronary artery aneurysms
when administered promptly during the acute phase of the illness. However, a subset of patients
may be refractory to initial treatment, highlighting the need for alternative therapies and ongoing
research to improve outcomes. Long-term cardiac monitoring is essential to detect and manage
late cardiovascular complications, including coronary artery stenosis and myocardial infarction.

Recommendation

In managing Kawasaki disease cases, prompt recognition and treatment are essential.
Healthcare providers should maintain a high index of suspicion for Kawasaki Disease in children
presenting with prolonged fever and characteristic clinical features. Early initiation of intravenous
immunoglobulin (IVIG) therapy, typically within the first ten days of illness onset, along with
aspirin therapy, has been shown to reduce the risk of coronary artery complications.
Multidisciplinary collaboration among pediatricians, cardiologists, rheumatologists, and infectious
disease specialists is essential to ensure comprehensive care and optimize patient outcomes.
Long-term follow-up with regular cardiac assessments, including echocardiography, is crucial for
monitoring coronary artery abnormalities and other cardiovascular anomalies. Education of
caregivers about the signs and symptoms of Kawasaki Disease and the importance of
adherence to treatment and follow-up protocols is also essential. By implementing these
recommendations, healthcare providers can effectively manage KD cases and reduce the risk of
long-term cardiovascular complications.
Reference (APA format)

Gerding, R. (2011). Kawasaki Disease: A review. Journal of Pediatric Health Care, 25(6), 379–
387.

https://doi.org/10.1016/j.pedhc.2011.07.007

Dionne, A., Melish, M. E., Newburger, J. W., & Dahdah, N. (2019). The treatment of Kawasaki
syndrome with corticosteroids. The Journal of Pediatrics, 209, 38-44. Gordon, J. B., Kahn, A. M.,
Burns, J. C., & Institute of Medicine (US) Committee on the Prevention of Destructive Kawasaki
Disease (2020)

(Signature)
Submitted by: Roel Villanueva
Year & Section

(Signature)
Submitted to: Mrs.Ria Bisaya
Clinical Instructor

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