Stable Microsystem TX An Plus

Texture Analyzer
application to qualify pharmaceutical products
Dr Lubna Abdalkarim Sabri

PhD Pharmaceutics, college of pharmacy,
University of Baghdad
What texture can tell us?
Texture and physical properties of any compound
can feel them, but---------
Can you measure them?????

 In the mid-1950, food industry, objective assessment of their
products,
 Texture analysis started to use which make Rheological
characteristics quantifiable
 General food Corporation Technical Center 1963, then develop
(Insteron-texturometer)
 Texture analyzer
The TA.XT plus
Texture Analyzer-
(Stable Microsystem)
 cost-effective method to determine the effects of raw material or
excipient quality or the adjustment of formulation or
processing variables on end product acceptability (control the
impact of changing ingredients or formulations on quality)
 Assess any problematic textural issues occur during storage or
transportation
 effective means of comparison with competitive products.
A Texture Analyzer is a texture measurement system
that moves up or down to compress or stretch a
sample. In a simple test, the analyzer's traveling arm is
fitted with a load cell.
It records the force / or % strain response of the sample

to the deformation that it is undergoing by (tension,
compression, bending).
To be successful, all tests depend
 the selection of the correct testing method,
 the manufacturing precision of the probe or
attachment used
 the accuracy of the analytical software to provide the
results in a clear, concise format
Basic force/deformation curve
Accessories :
HDP/90 Heavy Duty Platform

Probes
Calibration and T.A setting
* Standard Operating Procedures (SOPs): Texture Analyzer TA-Xtplus

https://www.youtube.com/watch?v=WUc5yFqAkVA
T.A Setting
From Library A series of classical TA tests
are are available for selection
Running Test
Textural properties of Topical Formulations
“Evaluation of in vitro mucoadhesiveness and texture profile
analysis of doxycycline in situ hydrogels”
• The mechanical properties or texture properties obtained from operating

TPA2 mode and analyzed for hardness, compressibility, cohesiveness and
adhesiveness
Library ------- specific test------TPA

H
P/10, P/35 cylindrical

probe (perspex , graphite,
stain steel) twice compress
sample
 Hardness
 Adhesiveness A
 Compressibility
 cohesiveness
*V. G. R. PATLOLLA et al. Pharmazie 75 (2020)

In vitro mucoadhesion
The force required to detach the artificial mucus

membrane from the surface of hydrogel
The AUC values obtained from force-time curve
were converted to force-distance.
Tensile strength was measured as the peak

detachment force required to detach the
test hydrogel from the mucosa.
Measurement of Mucoadhesion of Tablets,
Gels, Powders & Films
“ Improved Texture Analysis for Hydrogel Characterization: Gel
Cohesiveness, Adhesiveness, and Hardness”
Julia Hurler et al .develop a fast and reliable method to characterize texture
properties of hydrogels, namely cohesiveness, adhesiveness, and hardness
* Journal of Applied Polymer Science, Vol. 125, 180–188 ,2012.

*Evidence-Based Complementary and Alternative Medicine Volume 2018, Article ID 9431819
Carbopol hydrogel retained its original texture to a great extent (93%) after
the addition of liposome dispersion up to 15% (w/w)
While chitosan hydrogels with incorporated of liposomal dispersion retained

only 40% of their original properties, as compared to the intact gels
“ A Quantitative Disintegration Method for Polymeric Films”
quantitative disintegration technique which can be used to characterize

polymeric films in vitro without user bias
*J Pharm Innov. 2018 December ; 13(4): 321–329.

Conclusion
The operation of a texture analyzer is relatively simple,

versatile and cost-effectives
its capability to measure multiple samples within a short
period of time. In addition, it is also possible to utilize
the same instrument for different dosage forms by
changing either the testing probes or the measurement
parameters

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Texture Analyzer

application to qualify pharmaceutical products

Dr Lubna Abdalkarim Sabri

Can you measure them?????

It records the force / or % strain response of the sample

HDP/90 Heavy Duty Platform

* Standard Operating Procedures (SOPs): Texture Analyzer TA-Xtplus

• The mechanical properties or texture properties obtained from operating

Library ------- specific test------TPA

P/10, P/35 cylindrical

*V. G. R. PATLOLLA et al. Pharmazie 75 (2020)

The force required to detach the artificial mucus

Tensile strength was measured as the peak

* Journal of Applied Polymer Science, Vol. 125, 180–188 ,2012.

While chitosan hydrogels with incorporated of liposomal dispersion retained

quantitative disintegration technique which can be used to characterize

*J Pharm Innov. 2018 December ; 13(4): 321–329.

The operation of a texture analyzer is relatively simple,

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