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    Antiarrhythmics

    Uploaded by

    Nesrin M.Ali

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Antiarrhythmics

    Uploaded by

    Nesrin M.Ali
    7 views5 pages

    Original Title

    antiarrhythmics

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    Copyright:

    © All Rights Reserved
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    7 views5 pages

    Antiarrhythmics

    Uploaded by

    Nesrin M.Ali

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    Screening and Bioassay of

    Antiarrhythmics
    Dr. Ahmed Goda, Ph.D.
    Associate Professor
    Department of Pharmacology and Toxicology
    Faculty of Pharmacy, Tanta University
    Screening of antiarrhythmics
    (ACH+hypokalemia) Epinephrine-
    Electrical stimulation-induced
    Method  electrical stim.- induced
    arrhythmia
    induced arrhythmia arrhythmia
    In vivo
    Setting In vitro In vitro
    (under anesthesia??)
    Animal
    Rabbit, Guinea Pig Rabbit Dogs
    species
    Isolated
    Auricle Atrium
    organ
    PSS Ringer-Lock Modified Ringer
    ACH+hypokalemia
    Stimulus Electrical Epinephrine (IV)
    electrical stimulus
    Determine the maximal rate of
    elect. stim. that results in non-
    Assessed responsiveness “refract. period” Arrhythmia
    ECG monitoring
    before & after TTT suppression by TTT
    parameter
    ↑potency↓ max. elect. stim. rate (↑potency↓time)
    (Antiarrhythmics ↑ action potential
    duration “↑refractory period”)

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