P. Synopsis

FORMULATION DEVELOPMENT AND
EVALUATION OF CEFIXIME DISPERSIBLE

TABLETS
BY
BIKASH KUMAR
(AKU REG. NO: -19109164051)
GUIDED BY
MR. KUMAR VIKRAM
Asst. Professor & HOD (B. Pharm, M. Pharm, PGDCA, PhD)
Dept. of Pharmacy
GAUTAM INSTITUTE OF PHARMACY

VILL- SAIDBARHI, PO-JAITPUR, PS-CHANDI, DIST-NALANDA
Chandi road saiyad bahri, hilsa, Bihar -801307
FORMULATION DEVELOPMENT AND
EVALUATION OF CEFIXIME DISPERSIBLE
TABLETS
CONTENTS :-
S. N0. DESCRIPTION PAGE NO.
1. INTRODUCTION 3
2. AIM & OBJECTIVE 4
3. LITERATURE REVIEW 5
4. PROFILE OF DRUG 5-7
5. PLAN OF WORK 7
6. REFERENCE 8
1. INTRODUCTION :-
• Oral drug delivery has been known for decades as the most
widely utilized route of administration among all the routes that
have been explored for the systemic delivery of drug via various
pharmaceutical products of different dosage form. The reason
that the oral route achieved such popularity may be attributed
to its ease of administration as well as the traditional belief that
by oral administration the drug is well absorbed as the food stuff
ingested daily1
• The oral route of drug administration has been the one used
most for both conventional as well as novel drug delivery. The
reasons for this preference are obvious because of the ease of
administration and widespread acceptance by patients. The
common oral dosage forms include: liquid mixtures like
solutions, suspensions, solid dosage forms like tablets, capsules
and liquid filled capsules etc.
Page | 1
2 AIM & OBJECTIVE :-
2.1 AIM:-
The aim of this study is to formulation development and
evaluation of cefixime dispersible tablets in the
pharmaceutical lab.
2.2 OBJECTIVE:-
• Formulation of cefixime tablets by using Direct
Compression Method Procedure
• Evaluation of Pre-Coprameters
1) General Appearance
2) Hardness
3) Thickness
4) Weight Variation Test
5) Friability Test
Page | 2
3. LITERATURE REVIEW :-
A literature review on the formulation development and
evaluation of cefixime dispersible tablets would typically
involve gathering and summarizing existing research
and studies related to this topic. While I can't provide
direct access to specific papers or studies, I can outline
the key themes and findings you might encounter in
such a review.
Page | 3
4. PROFILE OF DRUG :-
Cefixime is used to treat bacterial infections in many
different parts of the body. It belongs to the class of
medicines known as cephalosporin antibiotics.
4.2 IUPAC NAME:-

(6R,7R)-7-{[2-(2-Amino-1,3-thiazol-4-yl)-2-
(carboxymethoxyimino)acetyl]amino}-3-ethenyl-8-oxo-
5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
4.2 BEFORE USING :-

In deciding to use a medicine, the risks of taking the
medicine must be weighed against the good it will do.
This is a decision you and your doctor will make. For this
medicine, the following should be considered:
4.3 ALLERGIES :-
Tell your doctor if you have ever had any unusual or
allergic reaction to this medicine or any other
medicines. Also tell your health care professional if you
have any other types of allergies, such as to foods,
dyes, preservatives, or animals.
Page | 4
4.4 DRUG INTERACTIONS :-
Although certain medicines should not be used together
at all, in other cases two different medicines may be
used together even if an interaction might occur.
4.5 PROPER USE :-Take this medicine only as directed by
your doctor. Do not take more of it, do not take it more
often, and do not take it for a longer time than your
doctor ordered.
4.5 DOSING :-
Adults and children older than 12 years of age and
weighing more than 50 kilograms (kg)—400 milligrams
(mg) once a day or 200 mg every 12 hours.
4.6 SIDE EFFECTS :-

Along with its needed effects, a medicine may cause
some unwanted effects. Although not all of these side
effects may occur, if they do occur they may need
medical attention.
Page | 5
5.PLAN OF WORK :-
Review of Literature
Marerials and Determination of Amount of

Methods Cefiximeto be used in a Tablet
Calibration of Standard Direct Compression Method

curve Procdure
Formulation of Tablet
Direct Compression Method Procedure
Evaluation of Pre-Coprameters
Result & Discussion
Page | 6
6. REFERENCES :-
1. Seager H, Drug-deliver products and the zydis fast-
dissolving dosage form, J Pharm Pharmacol, 1998, 50,
375-82.
2. Fu Y, Yang S, Jeong SH, Kimura S, Park K: Orally Fast
Disintegrating Tablets Developments, Technologies,
Taste-masking and Clinical Studies. Crit Rev Ther Drug
Carrier Sys 2004; 21:433-476.
3. Seager H: Drug-delivery products and the Zydis fast-
dissolving dosage. J Pharm Pharmacol 1998; 50(4):375-82
4. http:// www.unicef.org/ supply/ files/
Dispersible_Tablets.pdf.
5. Setia A, Goyal N, Kansal S. Formulation and evaluation
of Ciprofloxacin hydrochloride dispersible tablets using
natural substances as disintegrates Der Pharmacia
Sinica 2011
6. Rowe RC, Sheskey PJ, Quinn ME, editors. Handbook of
pharmaceutical excipients. 6th ed. Washington. A Joint
Publication of American Pharmaceutical Association and
The Pharmaceutical Press.
Page | 7
7. Bhanja SB, Ellaiah P, Roy HK, Samal BK, Tiwari S,
Murthy KVR. Formulation and Evaluation of Prindopril
Sublingual Talets. Int J Res Pharm Bio Sci.
8. Sindu Abraham, Basavaraj B V, Bharath S, Deveswaran
R, Sharon Furtado, Madhavan V. Formulation and
Optimization of Sublingual Tablets of Rabeprazole
Sodium. Int J Pharm Sci Res.
9. Bhanja Satyabrata, Hardel Danendra K, Sudhakar
Muvala. Formulation and Evaluation of Fast
Disintegrating Rosiglitazone Sublingual Tablets. Int J
Pharm Chem Sci.
10. Korsemeyer RW, Peppas NA. Macromolecular and
modeling aspects of swelling–controlled systems. In:
Mansdrofsz, rosemann TJ, ad, Controlled Release
Delivery systems. New York. Marcel Dekker; 1983.
Page | 8

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FORMULATION DEVELOPMENT AND

EVALUATION OF CEFIXIME DISPERSIBLE

GAUTAM INSTITUTE OF PHARMACY

4.2 IUPAC NAME:-

4.2 BEFORE USING :-

4.6 SIDE EFFECTS :-

Marerials and Determination of Amount of

Calibration of Standard Direct Compression Method

Direct Compression Method Procedure

Result & Discussion

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