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    Antidepressant Drugs

    Uploaded by

    Salv Fuent

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Antidepressant Drugs

    Uploaded by

    Salv Fuent
    13 views4 pages

    Copyright

    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    13 views4 pages

    Antidepressant Drugs

    Uploaded by

    Salv Fuent

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 4

    Chamizo’s Crusade Pharmacology

    Major Depression
    ANTIDEPRESSANTS
    Don’t give
    up!

    SSRIs- Selective Serotonin Reuptake Inhibitors.

    Drug List: Fluoxetine.


    Sertraline.
    Paroxetine.
    Citalopram.
    Escitalopram.

    Indications: Major depressive disorder, Anxiety, Bulimia nervosa, Bipolar


    disorder, OCD, Panic disorder, Premenstrual dysphoric disorder.

    Side Effects: Sexual Disfunction, Weight gain, Insomnia, Serotonin


    Syndrome(SS).

    TCAs- Tricyclic Antidepressants.

    Drug List: Amitriptyline.


    Nortriptyline.
    Protriptyline.
    Amoxapine.
    Desipramine.
    Imipramine
    Trimipramine.

    Indications: Depression, Enuresis, OCD, Pain Management( Migraine,


    Neuropathic pain, Post herpetic neuralgia), Panic Disorder,
    Premenstrual Syndrome, Phantom Limb Pain.

    Side Effects: Orthostatic Hypotension, Sedation, Anticholinergic effects(


    ACE), Seizures, Hypomania, Impotence, Tremor, Edema,
    Delayed Micturition.
    MAOIs- Monoamine Oxidase Inhibitors.

    Drug List: Selegiline


    Isocarboxazid
    Phenelzine
    Tranylcypromine

    Indications: Depression, Panic Disorder, Social Phobia

    Third line of choice, when other meds don’t work or ECT can not be done.

    Side Effects: Anxiety, Agitation, Hypotension, Hypertensive Crisis( Tyramine


    foods)

    Important Notes:

    Mechanism of action

    SSRIs: Block Reuptake of Serotonin MAOIs: Block MAO Enzymes( Increase


    into Neurons. NE, Epinephrine, Dopamine,
    Tyramine, Serotonin)
    TCAs:
    Block Reuptake of NE,
    Serotonin.

    Block several receptors(


    Alpha, Histamine,
    Muscarinic)

    Recognizing Important Side Effects!!!!

    ACE Dry Mouth. SS Delirium


    Blurry Vision. Agitation
    Photophobia. Tachycardia
    Urinary Retention. Sweating
    Constipation. Myoclonus
    Sweating. Tremors
    Tachycardia. Shivering
    Hyperreflexia
    Anticholinergic Side Effects Management

    Chewing Gums Increase Fiber Intake

    Wear Sunglasses Take Medication at bed time

    Increase Fluid Intake

    TCAs Overdose Management- NO ANTIDOTE AVAILABLE!!!

    Gastric Lavage ECG Monitoring

    Activated Charcoal Give Phenytoin

    Maintain Patent Airway Give Benzodiazepines

    Hypertensive Crisis Management

    Avoid Tyramine Rich Administer


    Foods. PHENTOLAMINE( Rapid
    Keep Tyramine acting Beta Blocker)
    restrictions for 2 extra
    Weeks after Drug OR
    Discontinuation.
    Administer NIFEDIPINE(
    Calcium Chanel Blocker)

    Electroconvulsive Therapy Nursing Implications

    Keep Patient: NPO for 6-8 hours before Procedures.

    Remove: Dentures, Glasses, Contact Lenses, Hearing Aids.

    Have Patient: Void before the procedure.

    Administer: Atropine( Control Secretions)

    Methohexital( Short acting anesthetic)

    Succinylcholine( Muscle Relaxant)

    Oxygen( 100 %)

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