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    Microbiology (Mid Exam) (2023)

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    Microbiology (Mid Exam) (2023)

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    Microbiology (mid Exam )(2023)

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    Microbiology (Mid Exam) (2023)

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    samali253sam

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    of 5

    3rd year mid exam.

    Academic Year: 2022-2023

    MIC/303-microbiolosy department

    Q1 Define the following : (5 marks ).

    1.Immunogen 2- Antigen 3- Hapten 4- Toleroger

    Q2: Write a short note regarding the usage of antibodies as specific


    passive immunotherapy for treating tumors, and describe the problems
    which we are faced with the use of antibodies in this field. ( 5 marks )

    Q3:what is tyndallization and explain how is done? (5 marks )

    Q4:Choose the most correct answer: (25 marks)

    1.Regarding interferon; the following statement is the most correct:


    a) It does protect the virus-infected cell that produces it.
    b) Interferon, itself, is a potent antiviral agent.
    c) Interferons are almost always host species specific in function but
    are not specific for a given virus
    d) All of the above
    e) a and c.

    2.Regarding complement deficiency; the following statement is the most


    correct:
    a Deficiency of C2 and C4 results in SLE-like syndrome.
    b) Deficiency in factor B leads to increase neisserial infections.
    c) Deficiency of C1 causes hereditary angioedema.
    d) All of the above.
    e) a and b.
    3.Regarding type III hypersensitivity; the following statement is
    the most correct:
    a) It involves the binding of IgE antibodies to cell surface antigens.
    b) Antibody directed at cell surface antigens can activate complement.
    c) The result may be complement-mediated lysis.
    d) a and b
    e) b and C.

    4.a type I hypersensitivity reaction; the following statement is


    the most correct
    a) The result may be complement-mediated lysis.
    b) Graves disease is an example.
    c) Immunoglobulin D is the responsible antibody.
    d) All of the above. e. None of the above.

    5.Rgarding the prevention of graft rejection, the following are true except:
    a) The most important in donor sclection is the MHC identity with the recipient.
    b) ABO compatibility is essential.
    c) PCR may be used for tissue typing for HLA antigens.
    d) Immunosuppressive therapy is important especially in the case of auto-
    transplantation
    e) None of the above.

    6- Regarding the Hyper-acute rejection:


    a) It may occur due to previous sensitization of the recipient by blood
    transfusion
    b) A graft show signs of rejection after months or years.
    c) It is due to immediate reaction of antibodies and complement.
    d) a and b
    e) a and c.

    7- Concerning factor B, the following statement is true:


    a) It binds to the Fc region of normal circulating IgG.
    b) Classically, it is an IgM antibody.
    c) It binds to normal circulating IgA, forming IgM-IgA complexes,
    d) a and b
    e) None of the above.
    8- Chediak Higashi syndrome, the following statement is true:
    a) It is presented with congenital absence or hypoplasia of the thymus
    b) It is associated with sever T cell deficiency since birth.
    c) It is associated with low T- dependent antibodies.
    d) All the above
    e) None of the above.
    9- The following are causes of Secondary Immuno-deficiencies except:
    a) Chronic granulomatous disease
    b) Leucocyte adhesion deficiency
    c) Ataxia -telangiectasia
    d) a and b.
    e) None of the above.
    10- The mechanisms by which tumors evade immune recognition
    include:
    a) Tumors can not express neo-antigens, that are immunogenic.
    b) They may fail to express co-stimulatory molecules required for the activation of
    T cells.
    c) May induce specific immune tolerance. d All the above.
    e) band c.

    11- Concerning the immunity against tumors, the following statement is


    true:
    a) Specific immune responses are involved in tumor rejection.
    b) CMI plays a minor role in tumor rejection by production of anti-tumor antibodies
    c) Natural killer (NK) cells are important in mediating tumor rejection.
    d) a and c.
    e) band c.
    12- the adaptive immune system:
    a) Acts as a first line of defense b) Affords protection against re-exposure
    to the same pathogen.
    c) It has only cellular components.
    d) a and b.
    c) band c.
    13-Acute phase proteins:
    a) include C-reactive protein (CRP), fibrinogen, and mannose binding lectins.
    b) They are synthesized in the liver, usually in response to secondary cytokines.
    c) CRP can enhance phagocytosis.
    d) a and b.
    e) a and c.
    14- Neutrophils
    a) phagocytose invading organisms
    b) contribute to collateral tissue damage that occurs during inflammation.
    c) are part of adaptive immune system
    d) all of the above.
    e) a and b.

    15- Rh incompatibility can occur by


    a) The most common type occurs when an Rh-positive pregnant mother is exposed
    to incompatible- Rh fetal red blood cells secondary to feto-maternal hemorrhage
    during the course of pregnancy from spontaneous or induced abortion, trauma,
    invasive obstetric procedures, or normal delivery
    b) Rh incompatibility can also occur due to blood transfusion in some
    situations.
    c) the E antigen is the most immunogenic; therefore, it most commonly is involved
    in Rh incompatibility
    d) a and b.
    e) band c.
    16- The highest incidence of Rh incompatibility occurs among:
    a) Pregnant mother with blood group (At) and fetus with blood group (A+)
    b) Pregnant mother with blood group (A-) and fetus with blood group (A+).
    c)Pregnant mother with blood group (A-) and fetus with blood group (B+).
    d) Pregnant mother with blood group (A+) and fetus with blood group (B +)
    e) Pregnant mother with blood group (A+) and fetus with blood group (A-)
    7- 1L5:-
    a) Activation & proliferation of B cells and production of IgF
    b) Activation & proliferation of neutrophiles which kill heliminthes.
    c)has a role in parasitic infection.
    d) a and b.
    e) a and c.

    18- Laboratory diagnosis of SLE:


    a) A screening test for antinuclear antibody (ANA) is highly specific.
    b) | The ANA test is sensitive.
    c) About 5% of healthy individuals and upto 30% of elderly individuals are
    ANA false positive .
    d) b and c
    e) a and b
    19- Regarding the immunogenicity of an antigen :
    a) Antigens that are easily phagocytosed are generally more immunogenic.
    b) The development of an immune response by T-independent antigens requires
    that the antigen be phagocytosed, processed and presented to helper T cells by an
    antigen presenting cell.
    c) D isomers of amino acids are not immunogenic because they cannot
    be degraded.
    d) a and c.
    e) a and b
    23-Filtration methods
    20- Ig M can be found as:
    a) paper Filtration
    a) monomer.
    b) leaf Filtration
    b) dimer.
    c) HEBA Filter
    c) quadrimer.
    d) a and B
    d) heptamer.
    e) oil Filtration
    el None of the above.

    21- The following is a fully human 24- One of the following is


    monoclonal antibody: not character of Plasmids
    a) Adalimumab. a) Extra dsDNA
    b)Efalizumab. b)Carry genes essential for
    c) Infliximab. growth
    d) Rituximab. c) Cary genes for drug resistan
    e) Etanercept d) Replicate autonomously

    25- Who discovered smallpox


    22- Moist heat sterilizatior
    vaccine
    a) Boiling
    a) Paul Erlich
    b) Steaming
    b) Robert Koch
    c) Ionizing
    c) louis pasteur
    d) a and C
    d) Edward Jenner
    e) a and B
    e) Joseph Lister

    Good Luck!

    saja Alashal

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