Sc120-Study-Guide 2
Sc120-Study-Guide 2
Sc120-Study-Guide 2
0 10-July-2020
The integument or integumentary system is a fancy name for a very important body
system. The skin, the largest organ in the body in terms of surface area, covers about two square
meters or 2.2 square feet of the adult human body. It is also the heaviest, with an average weight of
4.5-5.0 kg, and account for approximately seven percent of our body weight. It has an average
thickness of 1.5mm, thickest in areas exposed to wear and abrasion (palm and soles), and is
thinnest on the eyelids, external gentalia, and eardrum.
The skeletal system includes all of the bones and joints in the body. Each bone is a complex living
organ that is made up of many cells, protein fibers, and minerals. The skeleton acts as a scaffold by providing
support and protection for the soft tissues that make up the rest of the body. The skeletal system also
provides attachment points for muscles to allow movements at the joints. New blood cells are produced by the
red bone marrow inside of our bones. Bones act as the body’s warehouse for calcium, iron, and energy in the
form of fat. Finally, the skeleton grows throughout childhood and provides a framework for the rest of the body
to grow along with it.
Muscular system in response to stimuli, organisms move using their contractile proteins, actin and
myosin, which are associated by function. In unicellular organisms, these may involve amoeboid, ciliary or
flagella locomotion. On the cellular level, many cells process such as the contraction of the cleavage furrow
during mitosis, utilize these contractile proteins as well. In complex organisms, such as a higher animals and
man, muscles serve as motors which generate mechanical forces and motion. Muscular contraction is the
most important mechanism that animals have in response to environmental stimuli. Generally, muscles allow
locomotion, manipulation of objects, movement of food through the gut, circulation of blood and many other
movements. Muscle cells that are specialized in contraction contain high densities of actin and myosin. Such
cells are found attached to the skeleton and are responsible for the former’s movements. Others are located
in the walls of the gut, blood vessels, bladder and heart.
1. describe the layers of the skin, and their respective structure and function.
2. explain how the skin contributes to the regulation of body temperature, storage of blood, protection,
sensation, excretion and absorption, and synthesis of vitamin D.
3. Compare the structure, distribution, and functions of the accessory structures of the skin.
4. describe the effects of aging on the integumentary system.
5. Identify key medical terms associated with the integumentary system.
6. describe the structure and major functions of the skeletal system.
7. describe the structural and functional basis for the classification of bones.
8. distinguish between intramembranous and endochondral ossification.
9. explain the importance of the different types of bone formation and the process of bone remodeling.
10. distinguish between axial and appendicular skeleton
11. distinguish between the different types of joints
12. describe the types of movements that can occur at synovial joints.
13. describe the effects of aging on bones.
14. identify key medical terms associated with the skeletal system.
15. compare the three types of muscular tissue with regard to function and special properties.
16. describe the relationship between bones and skeletal.
17. explain how different muscle groups work together to produce movement.
18. explain the different features used in naming skeletal muscles.
19. identify and describe the major muscles of the body.
20. describe the effects of aging on muscles.
21. identify key medical terms associated with the muscular system.
INTEGUMENTARY SYSTEM
1. Protects the body by acting as barriers to microorganisms, water and excessive sunlight.
2. Protects it against dehydration and water absorption.
3. Regulates body temperature through heat loss from dilated vessels, evaporations from
perspiration, and retention from constricted vessels;
4. Serves for cutaneous sensation by its sensory receptors that respond to heat, cold pressure,
touch, vibration and pain.
5. Performs metabolic functions as in the synthesis of melanin, keratin and Vitamin D.
6. Contains organs like the sweat glands responsible for the excretion of nitrogenous wastes; and
7. Acts as a blood reservoir.
SKIN LAYERS
The figure below shows the three dimensional lateral cut of the human skin.
The epidermis as shown in figure 1, refers to the surface skin which is the outer protective layer of
the skin, it is between 30-50 cells layers thick. Epidermal cells are closely packed and highly mitotic.
As cells die in the top layers, new ones produce by the germinative layers are continuously being
pushed up. Four types of cells are present in the epidermis: keratinocytes produce keratin –
waterproof materials; melanocytes, melanin – pigmentation; Langerhans cells, macrophages –
garbage patrol; and Merkell cells, photoreceptors.
The epidermis is composed of five layers:
1. Stratum corneum, the outer layer is composed of 20-30 layers of keratinized and cornified
dead and flattened cells.
2. Stratum lucidum lies below the stratum corneum. It is composed of lucid and thin layer of
cells found only in the palms of the hands and the soles of the feet.
3. Stratum granulosum is just below the stratum lucidum. It is composed of granular cells that
contain keratin and deformed nuclei.
4. Stratum spinosum is several layers thick, with cells having dark nuclei and spiny projections.
5. Stratum basale is the deepest layer of the epidermis. It consists of a single layer of actively
dividing cells. The keratinocytes, melanocytes and Merkel cells are present in this layer.
Dermis. Located deeper than the epidermis, the dermis is composed of elastic and collagenous
fibers which function for stretch and strength, respectively. It also contains sweat glands,
sebaceous glands, nerve endings, and hair follicles, and is composed of two layers:
1. The upper papillary layer is composed of loose connective tissues with lots of blood vessels.
It also contains papillae, fingerlike projections which brings blood vessels near the epidermis
and help hold the two layers together. The arrangement of the papillae determines
fingerprints.
2. The reticular layer is deeper and thicker than the papillary layer and is composed of dense
and stretchable connective tissues.
1. Hair
Hair is found everywhere in the body except in the palms, soles, lips, penis, and others parts
of the female genitalia. There is a dense distribution of hair in the scalp, face, public area, and
underarms, while a fair distribution is noticeable in others body areas. Primarily, they function for
protection: from injury, sunlight and heat loss (the scalp hair's function); from foreign particles
(eyebrows and eyelashes); and from other airborne particles (hairs in the nostrils). A secondary
function of the hair is as a sexual attractant.
1. The shaft of the hair determines the curliness of the hair: round shaft (straight hair), oval shaft
(wavy hair), and flat shaft (kinky hair).
2. The bulb is the enlarged base of the follicle. The hair bulb forms the base of the hair follicle.
In the hair bulb, living cells divide and grow to build the hair shaft. Blood vessels nourish the
cells in the hair bulb, and deliver hormones that modify hair growth and the structure at
different times of life.
3. The root is encased in an internal or epithelial root sheath (derived from the epidermis), and
an external or connective root sheath (derived from the dermis). It is therefore the interacting
part to dermis and hypodermis
4.
2. Nails
Nails are composed of hard plates of highly keratinized cells and are formed from the stratum
corneum of the epidermis. Aside from covering and protecting the dorsal surface of the fingernails
and toenails, they also help in grasping and picking small objects.
3. Glands
Skin glands are referred to as exocrine glands because their secretions are released to the
outside through the ducts. The skin glands include the sebaceous glands, sweat glands and
ceruminous glands.
a. Sebaceous glands are branched glands attached to the hair follicles. They secrete sebum, a
lipid substance directly into the skin surface. This is a natural skin cream because it lubricates
and waterproofs the skin. In addition, it performs the following: prevents the hair from
becoming brittle, prevents excessive evaporation of water, keeps the skin soft, and contains a
bactericidal property that inhibits bacterial growth.
b. Sweat (sudoriferous) glands or eccrine sweat glands are coiled tubular glands which
excrete perspiration or sweat onto the surface of the skin. They are of two types: eccrine and
apocrine. The eccrine glands are widely distributed over the body, especially on the forehead,
back palms, and soles. They produce sweat, watery mixture of salts, antibodies and
metabolic wastes. The apocrine glands which are much larger, are found in the axillary and
pubic regions. They produce a more viscuous and odoriferous secretion which act as sexual
attractant. Mammary glands are modified apocrine glands found within the breasts. They
secrete milk during lactation.
c. Ceruminous glands or ear wax glands are found in the external auditory canal. They
secrete cerumen or earwax which acts as insect repellant, and keeps the eardrum from dying.
4. Skin Color
1. Melanin can
be found in
shades of
yellow, brown,
and black.
The
melanocytes
make the
melanin,
which is
picked up by
the
keratinocytes
via
phagocytosis.
Melanin is
Figure 1. Melanocytes and Kerarinocytes important
because it protects DNA in the nucleus from UV radiation. Figure 2 shows the
phenomenon how the skin color of human differs and this is due to the secreted
melanosomes that can be of shade of dark to light.
2. Carotene is a yellow to orange pigment that accumulates in the stratum corneum as can
be seen in the figure 3 which is magnified portion of the stratum corneum. Further, this
pigment can also be found in the adipose tissue found in the hypodermis. Stores fats as
shock absorber (see figure 4).
a b
Life-Span Changes
We are more aware of aging-related changes in skin than in other organ systems, simply because we can
easily see them. Aging skin affects appearance, temperature regulation, and vitamin D activation. The
epidermis maintains its thickness as the decades pass, but as the cell cycle slows, cells tend to grow larger
and more irregular in shape. Skin may appear scaly because, at the microscopic level, more sulfur— sulfur
bonds form within keratin molecules. Patches of pigment commonly called "age spots" or "liver spots" appear
and grow. These are sites of oxidation fats in the secretory cells of apocrinc and eccrino glands and reflect
formation of oxygen free radicals.
The dermis becomes reduced as synthesis of the connective tissue proteins collagen and elastin slows. The
combination of a shrinking dermis and loss of some fat from the subcutaneous layer results in wrinkling and
sagging of the skin. Fewer lymphocytes delay wound healing. Some of the changes in the skin's appearance
result from specific deficits. Less oil from sebaceous glands means that the skin becomes considerably drier.
The skin's accessory structures also show signs of aging. Slowed melanin production causes hair to become
gray or white as the follicle becomes increasingly transparent. Hair growth slows, the hairs thin, and the
number of follicles decreases. Males may develop pattern baldness, which is hereditary but not often
expressed in females. A diminished blood supply to the nail beds impairs their growth, dulling and hardening
them.
Sensitivity to pain and pressure diminishes with age as the number of receptors falls. A ninety-year-old's skin
has only one-third the number of such receptors as the skin of a young adult.
The ability to control temperature falters as the number of sweat glands in the skin falls, as the capillary beds
that surround sweat glands and hair follicles shrink, and as the ability to shiver declines. In addition, the
number of blood vessels in the deeper layer decreases, as does the ability to shunt blood towards the body's
interior to conserve heat. As a result, an older person is less able to tolerate the cold and cannot regulate
heat. An older person might set the thermostat ten to fifteen degrees higher than a younger person in the
winter. Fewer blood vessels in and underlying the skin account for the pale complex. ions of some older
individuals. Changes in the distribution of blood vessels also contribute to development of pressure sores in a
bedridden person whose skin does not receive adequate stimulation.
Aging of the skin is also related to skeletal health. The skin is the site of activation of vitamin D, which requires
exposure to the sun. Vitamin D is necessary for the absorption of calcium by bone tissue. Many older people
do not get outdoors much, and the wavelengths of light that are important for vitamin D activation do not
readily penetrate glass windows. In addition, older skin has a diminished ability to activate the vitamin.
Therefore, homebound seniors often take vitamin D supplements to help maintain bone structure.
LEARNING ACTIVITY 1
1.Draw a Diagram of the skin including its accessory organs and label the parts.
2. Write your name, year, course and section and the date at the upper part of your activity sheets.
3.. Prepare your answers and sending it directly in the Learning Management System.
LEARNING ACTIVITY 2
1. explain how the skin contributes to the regulation of body temperature, storage of blood, protection,
sensation, excretion and absorption, and synthesis of vitamin D.
2. Write your name, year, course and section and the date at the upper part of your activity sheets.
3. Prepare your answers and sending it directly in the Learning Management System.
SUMMARY
The integumentary system consist of the skin, hair, nails, and variety of glands. The skin protects,
helps and regulate body temperature produces Vitamin D and detects stimuli.
Skin Layers
Epidermis
Dermis
Subcutaneous Layer or Hypodermis
More specific Appendages inside the Skin Layer of Human
Accessory organs of the Skin
Hair
Nails
Glands
Skin Color
Protects the body by acting as barriers to microorganisms, water and excessive sunlight.
Protects it against dehydration and water absorption.
Regulates body temperature through heat loss from dilated vessels, evaporations from
perspiration, and retention from constricted vessels;
Serves for cutaneous sensation by its sensory receptors that respond to heat, cold pressure,
touch, vibration and pain.
Performs metabolic functions as in the synthesis of melanin, keratin and Vitamin D.
Contains organs like the sweat glands responsible for the excretion of nitrogenous wastes; and
Acts as a blood reservoir.
As the body ages, blood flow to the skin is reduced, the skin becomes thinner and elasticity is lost.
Sweat and sebaceous glands are less active, and the number of melanocytes decreases.
REFERENCES
Human Anatomy and Physiology work Book and Laboratory Manual by Ho,Gan,Verbo,Guerrero pp
91
Seeley,Rod R., et. al. 2003. Anatomy and Physiology. 3 rd Ed. Mosby-yearbook Inc. USA.
Pp 160-161
Human Anatomy and Physiology by David Shier,Jackie Butler, Riccki Lewis 10th Ed. Pp 175-176
Penecilla Gerald, L. Formacion, N. Fandialan, N. Valmote, M. Sandoval, and N.
Esmeralda. 2003. Basic Concepts in Biology. Philppines: Trintas Publishing, Inc.. pp 119-124
http://fwf.ag.utk.edu/mgray/wfs493/Lectures/AmphibianPhysiology.pdf
http://www.scielo.br/pdf/zool/v34/1984-4689-zool-34-e20176.pdf
https://www.bscsd.org/site/handlers/filedownload.ashx?moduleinstanceid=809&dataid
4155&FileName=frog%20body%20systems.pdf
https://en.wikibooks.org/wiki/The_Organ_Systems/integumentary
http://www.thefrog.org/biology/skin/skin.htm
https://www.transtutors.com/biology-homework-help/zoology/functions-of-skin-of-frog/
https://www.wemed.com/skin-problems-and -treatments/picture-of-the-hair
https://en.wikibooks.org/wiki/The_Organ_Systems/integumentary
http://ehabhanhan.blogspot.com/2013/06/integumentary-system.html
http://pediaa.com/what-is-the-difference-between-frog-and-human-integumentary
system/
https://www.google.com/search?q=skin+of+frog+parts&source=lnms&tbm=isch&sa=
&ved=0ahUKEwjw4OTf6vHgAhUadt4KHfj9C1oQ_AUIDigB&biw=1366&bih=625
mgrc=HQEax36SD2d3MM
SKELETAL SYSTEM
Long bones are typically longer. Ex. Are bones of the limbs (femur).
Short bones are generally cube shaped. Ex. Are wrist (carpals) and ankle bones (tarsal).
Flat bones are thin, flattened, and usually curved. Ex. Are ribs, breast, and cranial bones.
Irregular bones, like vertebrae and hip bones (pelvis), vary in shape.
Cartilaginous/Endochondral Ossification – bones are developed from cartilage models. Ex. Short
and long bones.
Membranous – bones are form to connective tissue membranes. Ex. Frontal and parietal bones of
the skull, and mandible.
Structure
Spongy or Cancellous bone is composed of branching beams of hard bones called trabeculae and
open spaces. It is found in the inner portion of a bone organ.
Compact bone is formed by solid matrix of cylindrical units called osteons or Haversian systems that
are tightly packed together. It is mostly found at the diaphysis of long bones.
Location
Axial skeleton consists of 80 bones that are located along the central axis of the body. This includes
the skull, hyoid, spinal column, ribs and sternum.
Appendicular skeleton consist of 126 bones that are located in the peripheral part of the body. This
includes the upper and lower extremities.
The figure below shows the human skeletal system and its different parts.
1. Movement: Skeletal system provides points of attachment for muscles. Your legs and arms move
when the muscles pull on the bones.
2. Support: The backbone is the main support center for the upper body. It holds your head up and
protects your spinal cord.
3. Protection: The bones of your skull protect your brain. Your ribs protect your lungs and hearth from
injury.
4. Makes blood: Red and white blood cells are formed by tissue called marrow, which is in the center of
the bone.
5. Storage: Bones store minerals, such as calcium and phosphorus, for use by the body.
Animals have three different types of support systems namely: hydrostatic skeleton, exoskeleton and
endoskeleton. A skeletal system is necessary to support the body, protect internal organs, and allow for the
movement of an organism.
1. Hydrostatic Skeleton
A hydrostatic skeleton is one that contains no rigid, hard structures or bones for support, but
rather relies on a fluid-filled cavity surrounded by muscles. It is the skeleton adopted by worms,
starfish and other invertebrates, and carries with it a number of advantages and disadvantages over a
more solid frame.
2. Exoskeleton
An exoskeleton is an external skeleton that consists of a hard encasement on the surface of
an organism. For example, the shells of crabs and insects are exoskeletons. This skeleton type
provides defense against predators, supports the body, and allows for movement through the
contraction of attached muscles.
3. Endoskeleton
An endoskeleton is a skeleton that consists of hard, mineralized structures located within the
soft tissue of organisms. An example of a primitive endoskeleton structure is the spicules of sponges.
The bones of vertebrates are composed of tissues, whereas sponges have no true tissues.
Endoskeletons provide support for the body, protect internal organs, and allow for movement through
contraction of muscles attached to the skeleton.
1. Axial Skeleton - composed of 80 bones; the axial bone forms the vertical axis of the body and
renders support to the organs of the head, neck and trunk. The figure below shows the axial skeleton
includes all the bones along the body’s long axis.
A. SKULL
1. Crani
al
C. RIBS - pairs of 12 thin, flat, curved bones form a around the organs the upper body.
2. Appendicular skeleton- this is composed of 126 bones of the upper and lower extremities, and the
pectoral and pelvic girdles and anchors the appendages to the axial skeleton. The figure below shows
the appendicular skeleton includes all
the bones that form the upper and
lower limbs, and the shoulder and
pelvic girdles.
A. Upper extremities - consist of the arms, the forearms, and the hands.
1. Brachium or arm
2. Antibrachium or forearm
3. Hand
The figure below shows the parts of the upper extremities of the body.
2. Leg
3. Pes or foot
4. Patella or kneecap
The figure below shows the parts of the lower extremities of the body.
C. Pectoral girdle or the shoulder - girdle is composed of four bones, two clavicles, and two
scapulae.
1. Clavicle
2. Scapula
The figure below shows the pectoral girdle consists of two bones, the scapula and clavicle
CLASSIFICATION OF BONES
The 206 bones that compose the adult skeleton are divided into four categories based on their
shapes.
4. Irregular Bones -
group.
STRUCTURE OF BONES
Bones are composed of two types
of tissue:
The figure below is the Compact
bone and Spongy bone.
The point at which two or more bones meet is called a joint or articulation. Joints are responsible for
movement (e.g., the movement of limbs) and stability (e.g.,the stability found in the bones of the skull). There
are two ways to classify joints: on the basis of their structure or on the basis of their function.
The structural classification divides joints into fibrous, cartilaginous, and synovial joints depending on the
material composing the joint and the presence or absence of a cavity in the joint. The functional classification
divides joints into three categories: synarthroses, amphiarthroses, and diarthroses.
Fibrous Joints
The bones of fibrous joints are held together by fibrous connective tissue. There is no cavity, or space,
present between the bones, so most fibrous joints do not move at all. There are three types of fibrous joints:
sutures, syndesmoses, and gomphoses. Sutures are found only in the skull and possess short fibers of
connective tissue that hold the skull bones tightly in place.
Syndesmoses are joints in which the bones are connected by a band of connective tissue, allowing for more
movement than in a suture. An example of a syndesmosis is the joint of the tibia and fibula in the ankle. The
amount of movement in these types of joints is determined by the length of the connective tissue fibers.
Gomphoses occur between teeth and their sockets; the term refers to the way the tooth fits into the socket like
a peg. The tooth is connected to the socket by a connective tissue called the periodontal ligament. Fibrous
joints classified as synarthroses, or immovable, include: sutures, gomphoses, and synchondroses
Cartilaginous joints are those in which the bones are connected by cartilage. There are two types of
cartilaginous joints: synchondroses and symphyses. In a synchondrosis, the bones are joined by hyaline
cartilage. Synchondroses are found in the epiphyseal plates of growing bones in children. In symphyses,
hyaline cartilage covers the end of the bone, but the connection between bones occurs through fibrocartilage.
Symphyses are found at the joints between vertebrae and between the pubic bones. Amphiarthroses allow
only slight movement; therefore, either type of cartilaginous joint is an amphiarthrosis.
Synovial Joints
Synovial joints are the only joints that have a space between the adjoining bones. This space, referred to as
the synovial (or joint) cavity, is filled with synovial fluid. Synovial fluid lubricates the joint, reducing friction
between the bones and allowing for greater movement. The ends of the bones are covered with articular
cartilage, a hyaline cartilage. The entire joint is surrounded by an articular capsule composed of connective
tissue. This allows movement of the joint as well as resistance to dislocation. Articular capsules may also
possess ligaments that hold the bones together. Synovial joints are capable of the greatest movement of the
three structural joint types; however, the more mobile a joint, the weaker the joint. Knees, elbows, and
shoulders are examples of synovial joints. Since they allow for free movement, synovial joints are classified as
diarthroses.
The structural classification of joints is based on whether the articulating surfaces of the adjacent bones are
directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each
other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three
structural classifications. A fibrous joint is where the adjacent bones are united by fibrous connective tissue.
At a cartilaginous joint, the bones are joined by hyaline cartilage or fibrocartilage. At a synovial joint, the
articulating surfaces of the bones are not directly connected, but instead come into contact with each other
within a joint cavity that is filled with a lubricating fluid. Synovial joints allow for free movement between the
bones and are the most common joints of the body.
The functional classification of joints is determined by the amount of mobility found between the adjacent
bones. Joints are thus functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly
moveable joint, or as a diarthrosis, which is a freely moveable joint (arthroun = “to fasten by a joint”).
Depending on their location, fibrous joints may be functionally classified as a synarthrosis (immobile joint) or
an amphiarthrosis (slightly mobile joint). Cartilaginous joints are also functionally classified as either a
synarthrosis or an amphiarthrosis joint. All synovial joints are functionally classified as a diarthrosis joint.
SYNARTHROSIS
An immobile or nearly immobile joint is called a synarthrosis. The immobile nature of these joints provide for
a strong union between the articulating bones. This is important at locations where the bones provide
protection for internal organs. Examples include sutures, the fibrous joints between the bones of the skull that
surround and protect the brain (Figure 1), and the manubriosternal joint, the cartilaginous joint that unites the
manubrium and body of the sternum for protection of the heart.
AMPHIARTHROSIS
An amphiarthrosis is a joint that has limited mobility. An example of this type of joint is the cartilaginous joint
that unites the bodies of adjacent vertebrae. Filling the gap between the vertebrae is a thick pad of
fibrocartilage called an intervertebral disc (Figure 2). Each intervertebral disc strongly unites the vertebrae but
still allows for a limited amount of movement between them. However, the small movements available
between adjacent vertebrae can sum together along the length of the vertebral column to provide for large
ranges of body movements.
Another example of an amphiarthrosis is the pubic symphysis of the pelvis. This is a cartilaginous joint in
which the pubic regions of the right and left hip bones are strongly anchored to each other by fibrocartilage.
This joint normally has very little mobility. The strength of the pubic symphysis is important in conferring
weight-bearing stability to the pelvis.
DIARTHROSIS
A freely mobile joint is classified as a diarthrosis. These types of joints include all synovial joints of the body,
which provide the majority of body movements. Most diarthrotic joints are found in the appendicular skeleton
and thus give the limbs a wide range of motion. These joints are divided into three categories, based on the
number of axes of motion provided by each. An axis in anatomy is described as the movements in reference
to the three anatomical planes: transverse, frontal, and sagittal. Thus, diarthroses are classified as uniaxial
(for movement in one plane), biaxial (for movement in two planes), or multiaxial joints (for movement in all
three anatomical planes).
A uniaxial joint only allows for a motion in a single plane (around a single axis). The elbow joint, which only
allows for bending or straightening, is an example of a uniaxial joint. A biaxial joint allows for motions within
two planes. An example of a biaxial joint is a metacarpophalangeal joint (knuckle joint) of the hand. The joint
allows for movement along one axis to produce bending or straightening of the finger, and movement along a
second axis, which allows for spreading of the fingers away from each other and bringing them together. A
joint that allows for the several directions of movement is called a multiaxial joint (polyaxial or triaxial joint).
This type of diarthrotic joint allows for movement along three axes (Figure 3). The shoulder and hip joints are
multiaxial joints. They allow the upper or lower limb to move in an anterior-posterior direction and a medial-
lateral direction. In addition, the limb can also be rotated around its long axis. This third movement results in
rotation of the limb so that its anterior surface is moved either toward or away from the midline of the body.
Bones undergo a lifelong process of remodeling – mature bone tissue is removed and new bone tissue
is formed. Bone remodeling is a highly regulated process that maintains a balance between bone
resorption and formation, thus maintaining skeletal integrity.
This balance changes with increasing age, resulting in loss of bone tissue. The ageing bone has
reduced mineral content, and is prone to osteoporosis – a condition in which bones are less dense,
more fragile, and prone to fractures.
As people age the rate of bone resorption by osteoclast cells (multinucleated cells which contain
mitochondria and lysosomes that is responsible for bone resorption) exceeds the rate of bone formation
so bone weaken.
Osteoporosis is a common problem among older people, especially post-menopausal women, and is a
major cause of hip fractures in the elderly.
Reduced bone density of the vertebrae, combined with the loss of fluid in intervertebral discs, result in a
curved and shortened trunk.
This reduced bone density, and resulting poor posture, leads to pain, reduced mobility, and other
musculoskeletal problems.
The risk of injury increases because gait changes, instability, and loss of balance may lead to falls. [7]
Ageing Joints
Joint motion becomes more restricted and flexibility decreases with age because of changes in tendons
and ligaments.
As the cushioning cartilage begins to break down from a lifetime of use, joints become inflamed and
arthritic. [8]
LEARNING ACTIVITY 2
REFERENCES
https://m.ivyroses.com/HumanBody/Skeletal/SkeletalSystem.php
https://www.pharmatips.in/Articles/Human-Anatomy/Introduction-To-Skeletal-System-
Anatomy.aspx
https://opentextbc.ca/biology/chapter/19-1-types-of-skeletal-systems/
https://biologydictionary.net/skeletal-sydstem/
https://www.acls.net/human-sssskkeletal-system
https://nursingexamppaper.com/2017/12/the-skeletal-system-part-and-functions.html
https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Book
%3A_General_Biology_(Boundless)/38%3A_The_Musculoskeletal_System/
38.3%3A_Joints_and_Skeletal_Movement/38.3A
%3A_Classification_of_Joints_on_the_Basis_of_Structure_and_Function#:~:text=The
%20structural%20classification%20divides%20joints,synarthroses%2C
%20amphiarthroses%2C%20and%20diarthroses.
https://opentextbc.ca/anatomyandphysiology/chapter/9-1-classification-of-joints/
SUMMARY
Human skeleton
The healthy skeletal system is made up of bones, ligaments, and cartilage.
Bones Are Grouped into the Axial Skeleton and the Appendicular Skeleton
Bones of the appendicular skeleton facilitate movement, while bones of the axial skeleton protect
internal organs. All skeletal structures belong to either the appendicular skeleton (girdles and limbs) or to the
axial skeleton (skull, vertebral column, and thoracic cage).
STRUCTURAL CLASSIFICATION OF JOINTS
The structural classification of joints is based on whether the articulating surfaces of the adjacent
bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces
contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into
three structural classifications. A fibrous joint is where the adjacent bones are united by fibrous connective
tissue. At a cartilaginous joint, the bones are joined by hyaline cartilage or fibrocartilage. At a synovial
joint, the articulating surfaces of the bones are not directly connected, but instead come into contact with
each other within a joint cavity that is filled with a lubricating fluid. Synovial joints allow for free movement
between the bones and are the most common joints of the body.
MUSCULAR SYSTEM
TYPES OF MUSCLES
There are three main types of muscles- smooth, skeletal and cardiac – each performing special
functions in the body.
1. Skeletal muscles move the bones performing voluntary actions, like walking and running, as well as
breathing. Skeletal muscles are large and striated owing the regular pattern of arrangement of actin
and myosin filaments. They process many nuclei. A condition kwon as syncytium, because they
develop through the fusion of many individual cells.
2. Smooth muscles are the simplest muscle cells. They are under the control of the autonomic nervous
system, contracting continuously in a steady and a slow manner. Smooth muscles are elongated and
spindle-shape, processing a centrally- located nucleus per cell. The actin and myosin fibers are not
regularly arranged, so these are not obvious when the cells are viewed under a light microscope. The
cells are arranged in sheets, and are found in the walls of the digestive tract and blood vessels.
3. Cardiac muscles are found in the heart where the cells form long rows of fibers. Unlike other
muscles tissues, cardiac muscles contract independently of nerve supply since reflex activity and
electrical stimuli are contained within the cardiac muscles themselves. Thus, they move involuntarily
like the smooth muscles. Similar to the skeletal muscles, they process striations, but these are with
branches which connect the fibers together. They may have one or two nuclei. Each fibers is divided
into partitions or intercalated discs which serve as boundaries between cells.
Figure 1 show (a) Striated muscles possess dark and light striationsand many nuclei. (b) Smooth
muscles are spindle-shaped and have one nucleus per cell, but without distinct striations. (c) Cardiac muscles
have distinct striations, one or two cell nuclei and are branched. There are intercalary dics which separate the
cells from each other.
a b c
MUSCLE ACTION
Skeketal muscles produce movement by pulling on tendons, connective tissus that anchor muscles to
bones, which in turn pull on bones. Most mucsles pas arcoss a joint and are attached to the bones that form
the joint.
Muscles move body parts in an opposite or antagonistic manner. The movement produced by one can
be reversed by the other. For example, the biceps of your upper arm allows you to pull your arm, while the
tricepss permits you to extend it once again. The muscle constracting to produce a particular action is called
an agonist, the other doing the opposite relaxing action is referred to as the antagonist. Muscles usually
work together as a group and as such several agonist and several antagonist coordinate with one another.
They can also switch roles as they move. The figure below shows how antagonistic action of the skeletal
muscles happen.
MUSCLE
STRUCTURE AND FUNCTION
Muscle contraction causes a skeletal part to move or may cause a change in the shape and size of a
soft tissue. Contraction results from the gliding past each other of the protein filament mentioned earlier,
notable: the thick myosin and thin actin connected by molecules bridges, the cross bridges. The filaments
form larger units, the myofibrils, which in turn form the muscle fiber. A skeletal muscle is composed of muscle
fibers.
The details of the molecules structure of a myofibril are shown in Figure 3 and 4. There is a partial
overlap of actin and myosin filament the A-band which appears as dark band. Where there are only actin
filaments and no overlap occurs the myofibril appears light, forming the I-band, hence the dark and light
striations in skeletal muscle. One whole A-band plus two halves of the I-band on both sides constitute a
sarcomere, the functional unit of the skeletal muscle. Note that myosin filaments consist of long polypeptide
tails and globular heads Actin consists of two chains of monomers twisted each other. Two polypeptide chains
of tropomyosin twist around the actin chains (see Figure 3).
Figure 4: The Structure of the skeletal muscle from tissues down to molecules
The gliding filament theory of muscle contraction was proposed by Huxley and Huxley (cited by
Purves, et al. 1995) to explain how muscles contract (Fig. 3.5b).
The acting filaments move toward the middle of the myofibril. The myosin heads attach to binding sites in
the action filament. Calcium and ATP are required in the process. As this occurs, the muscle shortens, and
when many sarcomeres contract simultaneously, they cause the muscle as a whole to contract.
Figure 4 shows the structure of a myofibril showing the orderly arrangement of the filaments (a); and
the sliding filament theory of muscular contraction (b). The amount of overlap of the myofibril increase during
contraction, thus shortening the sarcomere (b). Refer to the text for the identification of the bands in (a).
Many muscles of the body perform strenuous activities which require a continuous supply of energy. ATP
is the immediate effect source of energy in muscle contraction. However in strenuous activities sufficient
energy can be stored in ATP for only a few second. Thus, the muscle must have other energy sources, such
as creatine phosphate (CP), which can be stockpiled. Energy from creatine phosphate can be transferred to
ATP. Similarly, during strenuous exercise the supply of CP does not last long, and muscle cells must
replenish thier supply of these energy-rich compounds.
Recall that glycogen, a large polysaccharide, is stored in muscle fibers and the liver. Stored glycogen is
degraded, yielding glucose which is broken down cellular respiration. When oxygen is sufficient, enough
energy is captured from glucose to produce the required quantities of ATP.
During continuous exercise, oxygen supply may not be sufficient to meet the needs of rapidly metabolizing
cells. Under this condition, muscle cells can undergo anaerobic (without oxygen) metabolism to produce
ATP rapidly, but in small quantities and for short periods of time. Muscle fatigue results with the depletion of
ATP. The accumulation of lastic acid during anaerobic respiration also contribution to muscle fatigue. Finally,
the depletion of glycogen and the build -up of lastic acid create an oxygen debt which should be paid back by
rapid breathing and aerobic metabolism. Observe how after running fast you need to stop for breath and
breathe in rapid succession, in order to replenish your oxygen supply. The action is your body's way of
repaying your oxygen debt.
The age-related loss of muscle function is known as Sarcopenia ], derived from the Greek words for
flesh (sarcos) and loss (penia) and its definition includes loss of muscle strength and power, as well as
reduced function [2]. It occurs with increasing age, and is a major component in the development of frailty.
The loss of muscle mass during the aging process is important clinically as it reduces strength and
exercise capacity, both which are needed to perform activities of daily living.
Sarcopenia is not a disease but rather refers specifically to the universal, involuntary decline in lean
body mass that occurs with age, primarily due to the loss of skeletal muscle. Systematic review and
meta-analyses among Japanese community-dwelling older adults suggest the prevalence of sarcopenia
(9.9% overall: 9.8% among men, and 10.1% among women), providing valuable information in
addressing sarcopenia prevention in the older community [4]. A narrative review published in International
Journal of Molecular Sciences (2020) provides new evidence regarding the mechanisms, evaluation and
detection methods, and spinal sarcopenia treatment modalities [5].
With increasing age, we lose muscle mass: lean muscle mass contributes up to 50% of total body
weight in young adults, but this decreases to 25% by 75 to 80 years [10]. Typical muscle changes with
age:
Reduction in lower limb muscle cross-sectional area have been observed to begin in early adulthood
and accelerate beyond 50 years of age.This reduction in muscle cross-sectional area associated with
decreases in contractile structures accompanied by increases in non contractile structures such as fat
and connective tissue. [11] A cross-sectional study [12] suggested that the older inpatient showed an
increase in the intramuscular quadricep muscle adipose tissue approx 1.7 times that of the healthy older
individuals. Also, the study observed increased intramuscular adipose tissue with older inpatients who
were unable to walk independently as compared to older inpatients who were able to walk freely.
The total number of muscle fibers is significantly reduced with age, beginning at about 25 years and
progressing at an accelerated rate thereafter The decline in muscle cross-sectional area is most likely
due to decreases in total fiber number, especially type II fast-twitch glycolytic fibers. This results in
reduced muscle power. ] A study examining 1-year changes in the physical functioning of older people
using the ICF framework showed a significant decrease in muscle strength (both hip abductors and knee
extensors) walking capacity, speed, mobility, sit-to-stand performance, upper extremity function, and
balance performance at the end of 1 year .
LEARNING ACTIVITY
SUMMARY
The muscular system is a set of tissues in the body with the ability to change shape. Muscle cells connect
together and eventually to elements of the skeletal system. When the muscle cells contract, force is created
as the muscles pull against the skeleton.
Actin and myosin are the main proteins used in muscle cells to produce a contraction. These two components
use ATP to pull against each other. They attach to each side of the cell, which shortens the cell as they move
past each other.
The muscular system relies on the coordinated action of millions of actin and myosin filaments pulling in the
same direction at the same time. To achieve this coordination, muscles are innervated by the nervous
system.
Skeletal muscle
Skeletal muscles are the only muscles that can be consciously controlled. They are attached to bones, and
contracting the muscles causes movement of those bones.
Any action that a person consciously undertakes involves the use of skeletal muscles. Examples of such
activities include running, chewing, and writing.
Smooth muscle
Smooth muscle lines the inside of blood vessels and organs, such as the stomach, and is also known as
visceral muscle.
It is the weakest type of muscle but has an essential role in moving food along the digestive tract and
maintaining blood circulation through the blood vessels.
Cardiac muscle
Located only in the heart, cardiac muscle pumps blood around the body. Cardiac muscle stimulates its own
contractions that form our heartbeat. Signals from the nervous system control the rate of contraction. This
type of muscle is strong and acts involuntarily.
Mobility
The muscular system’s main function is to allow movement. When muscles contract, they contribute to gross
and fine movement.
Stability
Muscle tendons stretch over joints and contribute to joint stability. Muscle tendons in the knee joint and the
shoulder joint are crucial in stabilization.
Posture
Skeletal muscles help keep the body in the correct position when someone is sitting or standing. This is
known as posture.
Circulation
The heart is a muscle that pumps blood throughout the body. The movement of the heart is outside of
conscious control, and it contracts automatically when stimulated by electrical signals.
Smooth muscle in the arteries and veins plays a further role in the circulation of blood around the body. These
muscles maintain blood pressure and circulation in the event of blood loss or dehydration.
They expand to increase blood flow during times of intense exercise when the body requires more oxygen.
Respiration
The diaphragm is a dome-shaped muscle located below the lungs. When the diaphragm contracts, it pushes
downward, causing the chest cavity to get bigger. The lungs then fill with air. When the diaphragm muscle
relaxes, it pushes air out of the lungs.
When someone wants to breath more deeply, it requires help from other muscles, including those in the
abdomen, back, and neck.
Digestion
The muscular system allows for movement within the body, for example, during digestion or urination.
Smooth muscles in the gastrointestinal or GI tract control digestion. The GI tract stretches from the mouth to
the anus.
Food moves through the digestive system with a wave-like motion called peristalsis. Muscles in the walls of
the hollow organs contract and relax to cause this movement, which pushes food through the esophagus into
the stomach.
The upper muscle in the stomach relaxes to allow food to enter, while the lower muscles mix food particles
with stomach acid and enzymes.
The digested food moves from the stomach to the intestines by peristalsis. From here, more muscles contract
to pass the food out of the body as stool.
Urination
The urinary system comprises both smooth and skeletal muscles, including those in the:
bladder
kidneys
penis or vagina
prostate
ureters
urethra
The muscles and nerves must work together to hold and release urine from the bladder.
Urinary problems, such as poor bladder control or retention of urine, are caused by damage to the nerves that
carry signals to the muscles.
Childbirth
Smooth muscles in the uterus expand and contract during childbirth. These movements push the baby
through the vagina. Also, the pelvic floor muscles help to guide the baby’s head down the birth canal.
Vision
Six skeletal muscles around the eye control its movements. These muscles work quickly and precisely, and
allow the eye to:
Organ protection
Muscles in the torso protect the internal organs at the front, sides, and back of the body. The bones of the
spine and the ribs provide further protection.
Muscles also protect the bones and organs by absorbing shock and reducing friction in the joints.
Temperature regulation
Maintaining normal body temperature is an important function of the muscular system. Almost 85 percent of
the heat a person generates in their body comes from contracting muscles.
When body heat falls below optimal levels, the skeletal muscles increase their activity to make heat. Shivering
is one example of this mechanism. Muscles in the blood vessels also contract to maintain body heat.
Body temperature can be brought back within normal range through the relaxation of smooth muscle in the
blood vessels. This action increases blood flow and releases excess heat through the skin.
REFERENCES
http://www.ftcollinspersonaltrainer.com/2017/04/different-types-muscle-tissue/
1http://leavingbio.net/skeleton-muscles/
https://www.researchgate.net/figure/Structure-of-skeletal-muscle-From-Raven-et-al-82-Fig-36
original-in-Sherwood_fig1_266680796
http://grants.hhp.coe.uh.edu/clayne/6397/unit3.htm
https://biologydictionary.net/muscular-system/#:~:text=The%20muscular%20system%20is%20a,muscles
%20pull%20against%20the%20skeleton
https://www.physio-pedia.com/Muscle_Function:_Effects_of_Aging