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    COO v7 1501 1

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    kuwait jain
    Aging (or senescence) is that period of life, characterized by a series of progressive irreversible changes affecting the cells, tissues and organs, therefore of the whole organism, which begin when this, once development is complete, has reached a adulthood, and continue to manifest themselves, culminating in death, which occurs as a consequence of them and not by the intervention of external factors

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    COO v7 1501 1

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    kuwait jain
    5 views2 pages
    Aging (or senescence) is that period of life, characterized by a series of progressive irreversible changes affecting the cells, tissues and organs, therefore of the whole organism, which begin when this, once development is complete, has reached a adulthood, and continue to manifest themselves, culminating in death, which occurs as a consequence of them and not by the intervention of external factors

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    COO-v7-1501-1

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    Aging (or senescence) is that period of life, characterized by a series of progressive irreversible changes affecting the cells, tissues and organs, therefore of the whole organism, which begin when this, once development is complete, has reached a adulthood, and continue to manifest themselves, culminating in death, which occurs as a consequence of them and not by the intervention of external factors

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    5 views2 pages

    COO v7 1501 1

    Uploaded by

    kuwait jain
    Aging (or senescence) is that period of life, characterized by a series of progressive irreversible changes affecting the cells, tissues and organs, therefore of the whole organism, which begin when this, once development is complete, has reached a adulthood, and continue to manifest themselves, culminating in death, which occurs as a consequence of them and not by the intervention of external factors

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    of 2

    Clinics of Oncology

    Conceptual Paper ISSN: 2640-1037 Volume 7

    Manual And Skeletal Muscle Therapy Combined With Functional Exercise in


    the Treatment of Hip and Knee Prostheses: A Randomized Clinical Trial on a
    Biopsychosocial Model
    Giovanna C1, Furnari D1,2,4,5,7,8,9,10, Bagarella G1, Passanisi A1, Ayceman N1,7,10, Khan N3, Delaney M1, Cerna M1,5, Tiwari H1,
    Kumari VVM1, Hamlaoui K1, Lagree S1, Peace A1,2, Owens M1,2, Scott SL1,2, Gustin TL1,2, Crowle T1,2, Sanchez S1, Eyring A1,
    Talyanova E1, Milczarek M4, Aljayar A1, Ariet JJ1, Melnyk V1, Perren H1,2, Lee T1, Wanna S1, Petrov S1,7, Michel MM1,2, Santos
    C1, Peebles C6, Halg C1, Dalton E1, Goncalves L1,8, Kunrath AM1,8, Luna RS1,2,9 and Rodriguez MS1,2,9
    1
    Department of The Private Hospital Argento, Rehabilitation Department, Italy
    2
    Department of Lagree Studio, USA, Los Angeles;
    3
    Department of Pharmacology, College of Medicine and Health Sciences, UAEU
    4
    Department Monroe Medical, UK
    5
    Kimec Institute, USA
    6
    Indiana State University, USA
    7
    Lotus Academy, Ukraine
    8
    Instituto Tecnico Superior De Formarcion Integral Paraguaya
    9
    The Temple of Massage San Juan, Argentina
    10
    Öğr. Gör. presso A.Ü. Spor Bilimleri Fakültesi-Spor Sağlık Bilimleri ABD
    Received: 26 Feb 2024 Copyright:
    *
    Corresponding author:
    Accepted: 06 Apr 2024 ©2024 Furnari D, This is an open access article distribut-
    Dario Furnari,
    Published: 12 Apr 2024 ed under the terms of the Creative Commons Attribution
    Department of The Private Hospital Argento,
    J Short Name: COO License, which permits unrestricted use, distribution, and
    Rehabilitation Department, Italy
    build upon your work non-commercially.

    Citation:
    Furnari D, Manual And Skeletal Muscle Therapy Com-
    bined With Functional Exercise in the Treatment of Hip
    and Knee Prostheses: A Randomized Clinical Trial on a
    Biopsychosocial Model. Clin Onco. 2024; 7(10): 1-4

    Aging (or senescence) is that period of life, characterized by a se- to always be due to a greater production of free radicals (defined as
    ries of progressive irreversible changes affecting the cells, tissues ROS = Reactive Oxygen Substances). In reality, a certain amount
    and organs, therefore of the whole organism, which begin when of ROS is physiologically formed in the body’s cells, hence the
    this, once development is complete, has reached a adulthood, and excessive production of these or their poor elimination, has been
    continue to manifest themselves, culminating in death, which oc- considered one of the most significant causes of aging due to the
    curs as a consequence of them and not by the intervention of ex- fact that these free radicals interact with nucleic acids, proteins and
    ternal factors. Gerontology is the biological discipline that studies lipids, altering them structurally and functionally. the only cells
    this process, which can be considered both physiological, because that can have a maximum life span equal to that of the organism to
    it is normally present in the life span, and pathological because which they belong are perennial or post mitotic cells (neurons and
    it causes disturbances. The senile alterations, found in many or- muscle cells), that is, those without replicative activity. Certainly
    gans are quite distinct from the pathologies affecting the elderly; not all perennial cells live as long as the organism, as well demon-
    the branch of medicine, called Geriatrics, deals with the study of strated by the fact that the weight of the human brain, which is
    these whose appearance is certainly facilitated by the modifica- 1500 g at the age of 30, decreases on average to 1390 g at the age
    tions caused by aging. Lifespan:The reduction in life span seems of 90 years due to the programmed death that affects a large num-
    United Prime Publications., https://clinicsofoncology.org/ 1
    Volume 7 Issue 10 -2024 Conceptual Paper

    ber of neurons. It is currently established that labile and stable cells The reduction in muscle mass and strength therefore results from
    after having performed a certain number of mitoses in the culture the association of two factors, on the one hand the atrophy of mus-
    medium, experience aging phenomena, which prelude to death by cle cells and on the other the reduction of daily activity. It is proven
    apoptosis. “In vivo” the most important cellular changes that occur that in elderly subjects a regular muscle strengthening activity pro-
    in senescence consist in hypotrophy, which is mainly reflected in motes protein anabolism and slows down the inevitable reduction
    the reduction of muscle masses, and in the accumulation inside the in muscle mass and strength. Results demonstrate a great ability
    cells and also in the intercellular spaces of harmful materials: lipo- to respond to the training stimulus also in elderly people, which
    fucsins, substance amyeloid and metals. Physiological functions involves processes of synthesis and neuromotor plasticity even in
    in general improve from birth to 30 years of age, then a decline 80-year-old subjects. The cumulative effects of aging of the central
    begins, variable between the various functions, which is closely nervous system are linked to a 37% reduction in the number of
    linked to lifestyle. spinal nerve fibers and a 10% reduction in the speed of conduction
    Among these functions the most important: of excitement along the fibers. The execution time of relatively
    complex movements is greater in elderly subjects than in young
    Muscle strength
    people, with the same daily physical activity. Observations suggest
    Nervous function that maintaining a physically active lifestyle facilitates good pres-
    Respiratory function ervation of neuromuscular function. Osteoporosis represents the
    Cardiovascular function main problem of aging, especially in women after menopause. The
    Bone mass picture of osteoporosis involves the progressive demineralization
    of the bones which therefore become very fragile. For people over
    Normally there is a continuous remodeling of the motor units, in
    60, the reduction in bone mass can be 30-50%. Weight lifting can
    particular at the level of the neuromuscular plaque. The remode-
    counteract this phenomenon.
    ling process involves atrophy and therefore effective denervation
    on the one hand, but at the same time, the development of new
    axonic terminals. With age, the denervation mechanism prevails
    over the regenerative one, which induces muscle atrophy with irre-
    versible alterations, in particular for type II muscle fibers.

    United Prime Publications., https://clinicsofoncology.org/ 2

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