GENERAL PHYSTOLO Quesion Banh for CBMe LNS ) Define RmP DiSCusS the Genesis of RmpCIxg) OY BAS9Wite Abow Gibbs Donom &ouilibrium, NeYNSA IpotenHal 0nd Gold mannsHódahins &quation Angi-De.finitfon: An Sectrical potential diffekenceEx0sHN aCYOSs Hte. Cell menmbYahe in Lstng, gBa|e. is caled ReStinq membrane Potential
Gpecia {eatuYeA Of RMP
Smooth muscleGi--Somu nerve berg' ZOmy Gheletcl nuscle fberGi--90mV DRmP plaus animpotant Rale n deciding the deatee omd duaion of QcHOn potenkoL Tn Some tiasues like vgOHOl Bmooh muGcle Rmp is mot SBable [puctuaresl Genegis of Reshng TíembYane Potenhal. The Genesis of membrane 0ependS an Tao facioxs. JoMembra.ne factorg:-femeabuky of membre, Gibbs- DonaH Equkbrium, Nenst 8ouation, Goldmann-Hodqkin hat, Equahon DATE
| Membrone facloys DSelechiue Peumeabilky of MembYom. Cell membrane GSolekveu pemedble to iOng and &olute paAicles PULmeabilüs mainlus depends on molecular ciht and Kydxatod. ddius of ion Tongl&ubslances mw Hudraed Radua 34 3SS O12 Cat 40 Nat O18
membrane ts pYaCHCauimpMeable to inbacellul.or protein and Ordanic phosphak |) Gibbg Donan membroane Eailibrium uhen tuo SalukOnG Contalntn ionG are. Se,paYated by Semifpeameable. imembae Lat'Eanilibrldm £ach BoluHon coill be &lectrico neur foy a: Let theubeAwo Solakiong AandB COntaining. Sociumand Chloride and Sep2xaied. SemipMable membycne' then bua. |According to Gibbg DonanEquilibrium [NalACA roduckof dilngibleiong on Bohgides wllbeEgual (Batioof oiffusible iong)
ohen anondiffusible ions Saux[eratins,
Phosphates, Buphad esl ao addedom one. Side Cleisßay A)The Distibuion ww Changeio maintaun Eleceroneuraits
fox_produC af tauo gidesto he &quol
Poy obove condiHon,theeis unequa.
Oistribuion of Oiusibleions Theufore at &aulibYium NO i3 moYe On IheSide Containing Non ditusable anionandCl is More on oh Side: MoGJeUeY their ConcentaHon Tio is Equa TCF Containg non-diffusible. oniong lihe. proleins and oYaanicphosphaleThee fore ASummeiyicau disiyibuion cf diffusible iong 0CCurS acYOGS he celTmembr(ne utth caions being mOYe Outside than insic -ThewfoYe at wust fnteuor of Ceu 16 neqaive u genkasion in ions entalCulatinaole for uSed TA &quaLionof Kaig Hodgkin|5Goldman +130 70 - 9 90 - SS Na CRCm CCeTCE Tong 1empera bocy Cin al Eouahona ou(0q -15 ion b) Cel. 0wsiclu Conuntration Cour CalConcenraion ingidu Cin constant foxadys P: 7iValehu ion of keluun) TemahUu Cin eos T Congtant GaS UnivHG CohereR Cin CaLn RTCion 9mula for ídually ion Each poienkau foY CalCulaina Equakon for usedNOANAi iS II bRole of Tons)Pumps 9Role of 6iians |hey are presentin LaraeY COncentyaHon (m inai de ot ceL duL io high membr poueabili Lotof k'can diÇfuge out K* effuse Creaies. manimum neadivity îndcang t is mainy |Hesponsibie foY Deuuopment of RmP |uCues94 mv fngide eel RoeofNa ione hey l pregentmore Owgide of celthan insid. of ce membrane pmeabii sis (ess duto laaer diameter ofudraec ia' ico Na'Cam diffuse fromousidrtoinsidu upta cetain Extent Ts inus Cause nwraigationofpotaial upto "Smy They aepYesentinhigh conanYHOn OtBide Of ceLHnninsíd oftel membrqnpumeabillhyishiqh but enty la prOVenad. by Ekcironeqdhue ihsic cel Some caiong enteA butdonot contribte as ny accompany NaionG passiuely DATE
than he engid 0{CUl membrang
Poumeabilokyof CalauLM 610 Hmesless to hat cfu Co doesngiAaue CADC le in o/Rmp but itdo0S haue Lndid theaenesis ole Coinhibit& Nain.un undu Reating 8t0ge -ohea eCe Cois 1oo,Na Poxmeabilita inHdAE 9Role of NO-'pump |Di0c role, Rumps'3Nd ouw and 2Kingido CuaHnaneaaive inside by4my Tndiuct hole T matains tme gradiers {oY NaeK'ao66he cell membYane
K ditSion0Quisidu :-94mu diyusion to inSid a cilUSion to ingid: +8mu .mu pump -Lmu -90mv Boaic pYinciple. Thig_poHenna an beCacuuated by plaug mioeuctYadeS ane on guterside cd LOmotheY ingidQ ho ceU and Conneckng it to aa, Gengihe qaluanomeeY " |Na-ounp plaus animportant chlein maunes of Rmp by nainteaning 'he Ccncentvaron gyadiot
