Emmanuel_Mignot

Emmanuel Mignot
Emmanuel Mignot (born 1959 in Paris) is a sleep

researcher and director of the Stanford Center for Emmanuel Mignot
Sleep Sciences and Medicine, at Stanford University. Born 1959 (age 64–65)
Dr. Mignot is an authority on sleep research and Paris, France
medicine, and is mostly known for his work on Education Université Pierre and Marie
narcolepsy. He is the Craig Reynolds Professor of Curie
Sleep Medicine at Stanford Medical School, Stanford Necker-Enfants Malades,
University.[1] Université René Descartes
École Normale Supérieure
Known for Work on narcolepsy
Career Medical career
Dr. Emmanuel Mignot completed his Science Profession Medical doctor

Doctorate in Molecular Pharmacology at the Institutions Stanford Center for Sleep
Université Pierre and Marie Curie and went to medical Sciences and Medicine (https://p
school at Necker-Enfants Malades, Université René rofiles.stanford.edu/emmanuel-m
Descartes, with subspecialisation in Psychiatry. Dr. ignot)
Mignot is a former student of École Normale Sub- Psychiatry
Supérieure (Ulm). specialties
Following a postdoctoral fellowship at the Stanford Research Sleep disorders
Sleep Center, Mignot believed that understanding

narcolepsy could lead to breakthrough in new understanding of sleep. He was appointed assistant
professor of psychiatry and behavioral sciences at Stanford University in 1993, professor in 2001 and
director of the Center for Sleep Sciences and Medicine in 2011, succeeding William C. Dement. Trained
as a pharmacologist, he first deciphered the mode of action of modafinil, amphetamines, and
antidepressants on narcolepsy symptoms,[2] work that was done in close collaboration with Dr. Seiji
Nishino.
Starting in 1990, he isolated the gene causing canine narcolepsy in doberman and Labrador dogs. Ten
years later, this led to the discovery that mutations in the hypocretin (orexin) receptor 2 cause canine
narcolepsy,[3] and that human narcolepsy was caused by an immune mediated destruction of the
hypocretin (orexin) producing cells in the brain[4] Parallel work performed by Mashashi Yanagisawa,
Christopher Stinton and colleagues subsequently showed that hypocretin (orexin) deficient mice also
have narcolepsy.[5]
The autoimmune destruction of hypocretin (orexin) neurons in the hypothalamus was later shown by Han
and Mignot to be at least partially precipitated by influenza A infections, notably the H1N1 2009
pandemic strain,[6] complementing findings made in Northern Europe following the H1N1 Pandemrix
vaccination campaign.[7]
Dr. Mignot identified genetic factors predisposing to human narcolepsy, such as human leukocyte antigen
HLA DQB1*06:02 and other genes[8] and isolated the gene causing the methylopathy Autosomal
Dominant Cerebelar Ataxia, Deafness and Narcolepsy (ADCA-DN), DNMT1.[9]
Awards
Dr. Mignot has received numerous research grants and honors, including National Sleep Foundation and
National Institute of Health Research Awards, Howard Hughes Medical Institute Investigator and
McKnight Neuroscience awards, the Narcolepsy Network[10] professional service award, the Drs. C. and
F. Demuth 11th Award for Young Investigators in the Neurosciences, the WC Dement Academic
Achievement Award in sleep disorders medicine, the CINP and ACNP awards in neuropharmacology and
the Jacobaeus prize. He is an elected member of the Association of American Physicians and of the
Institute of Medicine of the National Academy of Sciences. He is the co-author of more than 200 original
scientific publications, and he serves on the editorial board of scientific journals in the field of sleep and
biology research. Dr. Mignot is an active member of several professional and governmental
organizations. He has been past president of the Sleep Research society, chair the National Center on
Sleep Disorders Research Advisory board of the National institutes of Health and chair of the Board of
Scientific Counselors of the National Institute of Mental Health. For 2023 he was awarded the
Breakthrough Prize in Life Sciences for discovering that narcolepsy is caused by the loss of a small
population of brain cells that make a wake-promoting substance, paving the way for the development of
new treatments for sleep disorders.[11]
Bibliography
Dr. Mignot has written many published works in the field of sleep medicine.[12][13]
See also
Narcolepsy
Hypersomnia
Kleine–Levin syndrome
References
1. Mignot, Em. "Prof" (http://med.stanford.edu/profiles/Emmanuel_Mignot/). Stanford.
Retrieved 28 September 2013.
2. Nishino, S.; Mignot, E. (May 1997). "Pharmacological aspects of human and canine
narcolepsy" (https://doi.org/10.1016%2Fs0301-0082%2896%2900070-6). Progress in
Neurobiology. 52 (1): 27–78. doi:10.1016/s0301-0082(96)00070-6 (https://doi.org/10.1016%
2Fs0301-0082%2896%2900070-6). ISSN 0301-0082 (https://search.worldcat.org/issn/0301-
0082). PMID 9185233 (https://pubmed.ncbi.nlm.nih.gov/9185233).
3. Lin, L.; Faraco, J.; Li, R.; Kadotani, H.; Rogers, W.; Lin, X.; Qiu, X.; de Jong, P. J.; Nishino,
S.; Mignot, E. (1999-08-06). "The sleep disorder canine narcolepsy is caused by a mutation
in the hypocretin (orexin) receptor 2 gene" (https://pubmed.ncbi.nlm.nih.gov/10458611).
Cell. 98 (3): 365–376. doi:10.1016/s0092-8674(00)81965-0 (https://doi.org/10.1016%2Fs00
92-8674%2800%2981965-0). ISSN 0092-8674 (https://search.worldcat.org/issn/0092-8674).
PMID 10458611 (https://pubmed.ncbi.nlm.nih.gov/10458611).
4. Nishino, S.; Ripley, B.; Overeem, S.; Lammers, G. J.; Mignot, E. (2000-01-01). "Hypocretin
(orexin) deficiency in human narcolepsy" (https://pubmed.ncbi.nlm.nih.gov/10615891).
Lancet. 355 (9197): 39–40. doi:10.1016/S0140-6736(99)05582-8 (https://doi.org/10.1016%2
FS0140-6736%2899%2905582-8). ISSN 0140-6736 (https://search.worldcat.org/issn/0140-
6736). PMID 10615891 (https://pubmed.ncbi.nlm.nih.gov/10615891).
5. Chemelli, R. M.; Willie, J. T.; Sinton, C. M.; Elmquist, J. K.; Scammell, T.; Lee, C.;
Richardson, J. A.; Williams, S. C.; Xiong, Y.; Kisanuki, Y.; Fitch, T. E.; Nakazato, M.;
Hammer, R. E.; Saper, C. B.; Yanagisawa, M. (1999-08-20). "Narcolepsy in orexin knockout
mice: molecular genetics of sleep regulation" (https://pubmed.ncbi.nlm.nih.gov/10481909).
Cell. 98 (4): 437–451. doi:10.1016/s0092-8674(00)81973-x (https://doi.org/10.1016%2Fs00
92-8674%2800%2981973-x). ISSN 0092-8674 (https://search.worldcat.org/issn/0092-8674).
6. Han, Fang; Lin, Ling; Warby, Simon C.; Faraco, Juliette; Li, Jing; Dong, Song X.; An, Pei;
Zhao, Long; Wang, Ling H.; Li, Qian Y.; Yan, Han; Gao, Zhan C.; Yuan, Yuan; Strohl,
Kingman P.; Mignot, Emmanuel (September 2011). "Narcolepsy onset is seasonal and
increased following the 2009 H1N1 pandemic in China" (https://pubmed.ncbi.nlm.nih.gov/21
866560). Annals of Neurology. 70 (3): 410–417. doi:10.1002/ana.22587 (https://doi.org/10.1
002%2Fana.22587). ISSN 1531-8249 (https://search.worldcat.org/issn/1531-8249).
7. Partinen, Markku; Saarenpää-Heikkilä, Outi; Ilveskoski, Ismo; Hublin, Christer; Linna, Miika;
Olsén, Päivi; Nokelainen, Pekka; Alén, Reija; Wallden, Tiina; Espo, Merimaaria; Rusanen,
Harri; Olme, Jan; Sätilä, Heli; Arikka, Harri; Kaipainen, Pekka (2012). "Increased incidence
and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination
campaign in Finland" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314680). PLOS ONE.
7 (3): e33723. Bibcode:2012PLoSO...733723P (https://ui.adsabs.harvard.edu/abs/2012PLo
SO...733723P). doi:10.1371/journal.pone.0033723 (https://doi.org/10.1371%2Fjournal.pone.
0033723). ISSN 1932-6203 (https://search.worldcat.org/issn/1932-6203). PMC 3314680 (htt
ps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314680). PMID 22470463 (https://pubmed.ncb
i.nlm.nih.gov/22470463).
8. Sehgal, Amita; Mignot, Emmanuel (2011-07-22). "Genetics of sleep and sleep disorders" (ht
tps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153991). Cell. 146 (2): 194–207.
doi:10.1016/j.cell.2011.07.004 (https://doi.org/10.1016%2Fj.cell.2011.07.004). ISSN 1097-
4172 (https://search.worldcat.org/issn/1097-4172). PMC 3153991 (https://www.ncbi.nlm.nih.
gov/pmc/articles/PMC3153991). PMID 21784243 (https://pubmed.ncbi.nlm.nih.gov/2178424
3).
9. Winkelmann, Juliane; Lin, Ling; Schormair, Barbara; Kornum, Birgitte R.; Faraco, Juliette;
Plazzi, Giuseppe; Melberg, Atle; Cornelio, Ferdinando; Urban, Alexander E.; Pizza, Fabio;
Poli, Francesca; Grubert, Fabian; Wieland, Thomas; Graf, Elisabeth; Hallmayer, Joachim
(2012-05-15). "Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness
and narcolepsy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465691). Human
Molecular Genetics. 21 (10): 2205–2210. doi:10.1093/hmg/dds035 (https://doi.org/10.109
3%2Fhmg%2Fdds035). ISSN 1460-2083 (https://search.worldcat.org/issn/1460-2083).
PMC 3465691 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465691). PMID 22328086
(https://pubmed.ncbi.nlm.nih.gov/22328086).
10. Guen, Le (2014-01-01). "Emmanuel Mignot, MD, PhD's Profile" (https://profiles.stanford.ed
u/emmanuel-mignot). Stanford Profiles. Retrieved 2024-08-12.
11. "Breakthrough Prize – Winners Of The 2023 Breakthrough Prizes In Life Sciences,
Mathematics And Fundamental Physics Announced" (https://breakthroughprize.org/News/7
3). Retrieved 2024-08-12.
12. "Selected Publications" (https://web.archive.org/web/20120111145438/http://med.stanford.e
du/school/Psychiatry/narcolepsy/publications.html). Stanford School of Medicine Center for
Narcolepsy. Archived from the original (http://med.stanford.edu/school/Psychiatry/narcoleps
y/publications.html) on January 11, 2012. Retrieved August 7, 2012.
13. "PubMed Search for Emmanuel Mignot" (https://pubmed.ncbi.nlm.nih.gov/?term=Mignot+E&
cauthor_id=32621581). Retrieved 14 July 2022.
Further reading
Bassetti, Claudio; Billiard, Michel; Mignot, Emmanuel, eds. (December 21, 2006).
Narcolepsy and Hypersomnia (1st ed.). Informa Healthcare. ISBN 978-0849337154.
External links
Official website (https://mignotlab.com)
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Emmanuel Mignot

Emmanuel Mignot (born 1959 in Paris) is a sleep

Dr. Emmanuel Mignot completed his Science Profession Medical doctor

Following a postdoctoral fellowship at the Stanford Research Sleep disorders

Sleep Center, Mignot believed that understanding

Retrieved from "https://en.wikipedia.org/w/index.php?title=Emmanuel_Mignot&oldid=1249414236"

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