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    Dipotassium Glycyrrhizinate

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    Mineral Vital
    Glycyrrhizin (C42H62O16): 3 - 8% in the licorice root Responsible for its sweetness. 250 times as sweet as cane sugar. Other well-known components: Flavonoid glycosides, chalcone glycosides and isoflavonoids.

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    Dipotassium Glycyrrhizinate

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    Mineral Vital
    181 views11 pages
    Glycyrrhizin (C42H62O16): 3 - 8% in the licorice root Responsible for its sweetness. 250 times as sweet as cane sugar. Other well-known components: Flavonoid glycosides, chalcone glycosides and isoflavonoids.

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    Glycyrrhizin (C42H62O16): 3 - 8% in the licorice root Responsible for its sweetness. 250 times as sweet as cane sugar. Other well-known components: Flavonoid glycosides, chalcone glycosides and isoflavonoids.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    181 views11 pages

    Dipotassium Glycyrrhizinate

    Uploaded by

    Mineral Vital
    Glycyrrhizin (C42H62O16): 3 - 8% in the licorice root Responsible for its sweetness. 250 times as sweet as cane sugar. Other well-known components: Flavonoid glycosides, chalcone glycosides and isoflavonoids.

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    DIPOTASSIUM GLYCYRRHIZINATE

    070628

    Components Of Licorice
    Main Active Principle:
    Glycyrrhizin (C42H62O16): 3 - 8% in the licorice root Responsible for its sweetness. Approx. 250 times as sweet as cane sugar.

    Other well-known components:


    Flavonoid glycosides, chalcone glycosides and isoflavonoids.
    COOH
    O

    O
    OH HO O O

    COOH OO OH HO O COOH O OH HO OH
    O HOH 2C OH OH

    Liquiritin

    Glycyrrhizin
    MARUZEN PHARMACEUTICALS CO., LTD.

    Review Of The Relevant Literature


    Pharmacological & Physiological Effects 1. Detoxicant effect 2. Anti-ulcerative 3. Anti-inflammatory 4. Decholesterolization 5. Anti-estrogenic 6. Anti-tussive 7. Anti-histaminic 8. Anti-allergic hepatitis 9. Lowering blood sugar 10. Anti-leukemic 11. Anti-tumor 12. Anti-biotic
    MARUZEN PHARMACEUTICALS CO., LTD.

    Review Of The Relevant Literature


    Three Main Actions of Licorice 1. Detoxicant effect
    Synergistic effect of glycyrrhizinic acid and methionine to improve the liver function with GOT and GPT.

    2. Anti-ulcerative effect
    - Licorice extract: Anti-gastric and Anti-duodenal ulcerative effect - Fractions (FM100) other than glycyrrhizinic acid: Anti-ulcerative effect - Succinic acid ester made from glycyrrhetinic acid (Disodium 3-succinyloxy-Beta-glycyrrhetinate): Therapeutic agent for gastric ulcers

    3. Anti-inflammatory effect
    - Glycryyhetinic acid: More effective than hydrocortisone for subacute or chronic skin diseases. - Hydrocortisone antagonism: Mode of action of glycyrrhetinic acid against the physiological actions of hydrocortisone.
    MARUZEN PHARMACEUTICALS CO., LTD.

    Dipotassium Glycyrrhizinate (DPG)


    COOH O

    COOK OO OH HO O COOK O OH HO OH

    C42H60K2O16

    <Features> - Effective in treating acute and chronic dermatitis supported by many clinical reports both in Japan and abroad in the field of dermatology. - Milder action, almost without side effects. - Widely used in cosmetics because of its chemical stability, good solubility and emulsifying properties. - An anti-inflammatory active constituent in Quasi-Drug in Japan.
    MARUZEN PHARMACEUTICALS CO., LTD.

    Dipotassium Glycyrrhizinate (DPG)


    <Description> White to faintly yellow crystalline powder, odorless,characteristic sweet taste <Stability> Heat: Very stable, but maybe decomposed if heated at over 100 degrees C for a long time. pH: When mineral acid is added to the aqueous solution of this product and drop pH under 4, the solution gels. <Solubility>
    Solvents Water 50Ethanol Dehydrated ethanol 1,3-Butylene glycol Propylene glycol Chloroform Ether
    MARUZEN PHARMACEUTICALS CO., LTD. : Very soluble : Insoluble

    20

    Inflammation
    Cell Membrane

    Mast Cell

    Ca

    IgE
    Ca

    Stimulation
    Mucous Membrane

    Phospholipids

    Hyaluronidase (non-active

    Hyaluronidase active

    PLA2

    Inflammation
    Hyaluronidase inhibition

    Redness, Edema, Fever, Pain, Dysfunction, etc.)


    Capillary Vasodilation Edema

    Arachidonic Acid Lipoxygenase Cyclooxygenase

    Degranulation

    LTs PGs
    Edema FeverPain, etc

    Histamine

    Pain, Itchiness, Redness


    Activation of Inflammatory Cell Vascular Permeability, etc Accelerate granular enzyme release MARUZEN PHARMACEUTICALS CO., LTD. Histamine release inhibition

    Inhibition of LTB4 and PGE2 production

    Inhibitory Effect on Hyaluronidase Activity


    <Anti-inflammation and Hyaluronidase>
    Inhibition of hyaluronidase plays an important role not only in maintaining the hyaluronic acid level in the body but also in anti-inflammatory and antiallergic activities.1) This enzyme is activated during inflammation, plays a role in the destruction of the connective tissue matrix, and increases the permeability of inflammatory cells and blood vessels. Hyaluronidase presents in mast cells in activated by the binding of IgE-antigen complex to receptors, and is involved in the release of histamine granules. So far anti-inflammatory agents such as indonethacin and antiallergic agents such as sodium cromoglicate have been reported as inhibitiors of hyaluronidase.

    Sample DPG Indomethacin Sodium cromoglicate

    IC50(g/mL) 3.4 39.0 11.0

    DPG was 11 times stronger than indomethacin and 3 times greater than sodium cromoglicate as positive controls.
    Ref: 1) Hisao Kakegawa, Chem Pharm Bull, Vol33 (9)3738-3744 (1985)

    MARUZEN PHARMACEUTICALS CO., LTD.

    Inhibitory Effects on Histamine Release

    DPG: Inhibition 83.4% --- Conc. at 1mg/mL

    DPG: Inhibition 86.4% --- Conc. at 2mg/mL

    Ref: Tadayoshi Shibata, Journal of WakanMedical and Pharmaceutical Society for WAKAN-YAKU 6, 294 (1989) MARUZEN PHARMACEUTICALS CO., LTD.

    Effects on Arachidonic Cascade

    DPG: Significantly inhibited the LTB4 production


    Ref: Norifumi Kawada, Inflammation 9(1), 29 (1989)

    DPG: Significantly inhibited PGE2 production

    MARUZEN PHARMACEUTICALS CO., LTD.

    Clinical Study
    Application Of Ointment With DPG For Atopic Dermatitis
    Journal of New Remedies & Clinics Vol. 12, No.6 (1983)

    Institute: Pediatric Department of Tochigi National Hospital Subject: 38 patients with atopic detmatitis (M: 17, F: 21) Test sample: Ointment with 1% DPG Application: Twice daily Evaluation: Objective symptom of skin rash, Subjective symptom of itching Result: In this clinical study, at least more than 15 days continuous application of the DPG-ointment is recommended. Number Significantly effective Effective No effect 6 16 16 42.1%
    Among 22 patients with effectiveness: 15 patients- - - More than 15 days application 7 patients - - - Less than 15 days application MARUZEN PHARMACEUTICALS CO., LTD.

    Effective % 57.9%

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