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CRISPR CAS9

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DNA AND CRISPR-CAS9 SYSTEM

WHERE IS DNA FOUND?

-DNA is in every cell of every living thing. It is found within the chromosomes of the cell. Chromosome
work to build proteins and assist in duplication or division of the cells.

GENES ARE MADE UP OF DNA

- ADENINE

- CYTOSINE

- THYMINE
- GUAMINE

GENOME- Is an organisms complete set of DNA

CRISPR-CAS9?

- It is a genome editing tool that is creating a buzz in the science world. It is faster, cheaper and more
accurate than previous techniques of editing DNA and has a wide range of potential applications.

CRISPR

2components

- cas9 protein

- crRNA

CRISPR represents a paradigm shift in our ability to edit and manipulate genes. From curing genetic
diseases to creating drought-resistant crops, the potential applications of CRISPR are vast and far-
reaching.

CRISPR: END OF DISEASES

CRISPR TO TREAT DISEASES


- Targeting DNA

- Fixing mutations

Eradicating disease at the root

- CRISPR offers possibility of a permanent cure. By correcting the underlying genetic mutations that
cause diseases.

BROAD APPLICABILITY

- The versatility of CRISPR makes it applicable to a vast array of genetic diseases.

IMPROVED HEALTH OUTCOME

- Eradicating genetic diseases through CRISPR could lead to significant improvements in public health

TREATING CANCER USING CRISPR

- Cancer is a significant global health challenge, CRISPR CAS9 SYSTEM is a highly precise gene editing tool
that can be used in changing cancer research and treatment.

CRISPR IN TARGETED CANCER THERAPIES

- CRISPR CAS9 has been used as a targeted therapy to tackle drug resistance and improve
immunotherapy for breast cancer.

POTENTIAL IMPACT OF CRISPR ON CANCER TREATMENT

- THE CRISPR system is revolutionizing the potential for precision cancer medicine.

OUR FUTURE WITH CRISPR-CAS9

Designer babies

- a designer baby is a baby whose genetic makeup has been selected or altered, often to exclude a
particular gene or to remove genes associated with disease.
Dr. He Jiankui

- Chinese biophysicist, who created the first genetically modified human babies.

Traits that could change in designer babies

- Gender

- Appearance

- Disease

- Intelligence

- Personality

Role of CRISPR in ANTI AGING

Can CRISPR prevent aging?

Understanding Naturally immortal organism

- Certain species like jellyfish and lobsters, exhibit

remarkable longevity traits.

- Traits include enhanced DNA repair and indefinite cell renewal

Applications CRISPR

1. Gene editing for functional studies

- facilitates gene modification in immortal organisms

- clarifies genes roles in aging processes

2. Comparative Genomics

- aids in identifying genetic variations associated with longevity

3. Model organism engineering


- enables creation of longevity- enhanced model organisms for lifespan studies

CRISPRS potential raises ethical concerns:

- off target effects

- unintended consequences of genetic manipulation

- equitable access to longevity interventions

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