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    Cebu Normal University: Drug Study

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    Gwen Marie Taboada
    The document discusses the drug Celecoxib (Celebrex), a nonsteroidal anti-inflammatory drug (NSAID) used for arthritis pain and inflammation. It is contraindicated for patients with asthma, aspirin allergy, severe liver or kidney disease, or in the third trimester of pregnancy. Common side effects include diarrhea, abdominal pain, headache and dizziness. Nurses should monitor patients for signs of gastrointestinal toxicity or hepatotoxicity and educate patients about proper dosage and reporting any side effects or symptoms that occur.

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    Cebu Normal University: Drug Study

    Uploaded by

    Gwen Marie Taboada
    616 views2 pages
    The document discusses the drug Celecoxib (Celebrex), a nonsteroidal anti-inflammatory drug (NSAID) used for arthritis pain and inflammation. It is contraindicated for patients with asthma, aspirin allergy, severe liver or kidney disease, or in the third trimester of pregnancy. Common side effects include diarrhea, abdominal pain, headache and dizziness. Nurses should monitor patients for signs of gastrointestinal toxicity or hepatotoxicity and educate patients about proper dosage and reporting any side effects or symptoms that occur.

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    The document discusses the drug Celecoxib (Celebrex), a nonsteroidal anti-inflammatory drug (NSAID) used for arthritis pain and inflammation. It is contraindicated for patients with asthma, aspirin allergy, severe liver or kidney disease, or in the third trimester of pregnancy. Common side effects include diarrhea, abdominal pain, headache and dizziness. Nurses should monitor patients for signs of gastrointestinal toxicity or hepatotoxicity and educate patients about proper dosage and reporting any side effects or symptoms that occur.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    616 views2 pages

    Cebu Normal University: Drug Study

    Uploaded by

    Gwen Marie Taboada
    The document discusses the drug Celecoxib (Celebrex), a nonsteroidal anti-inflammatory drug (NSAID) used for arthritis pain and inflammation. It is contraindicated for patients with asthma, aspirin allergy, severe liver or kidney disease, or in the third trimester of pregnancy. Common side effects include diarrhea, abdominal pain, headache and dizziness. Nurses should monitor patients for signs of gastrointestinal toxicity or hepatotoxicity and educate patients about proper dosage and reporting any side effects or symptoms that occur.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 2

    Cebu Normal University

    College of Nursing Osmea Blvd. Cebu City 6000

    DRUG STUDY
    NAME OF DRUG GENERIC NAME: CLASSIFICATION THERAPEUTIC: Analgesic, Antipyretic, Antiinflammatory PHARMACOLOGIC: Central Nervous System Agent, Cyclooxygenase 2 Inhibitor, NSAID PREGNANCY CATEGORY: C (first and second trimester), D (third trimester) MECHANISM OF ACTION NSAID that exhibits analgesic, antiinflammatory and antipyretic action. It inhibits prostaglandin synthesis by inhibiting cyclooxygenase-2, but doesnt inhibit cyclooxygenase-1. Pharmacokinetics: Peak: 3 hours. Distribution: 97 % protein bound; crosses placenta. Metabolism: Metabolized in liver by cytochrome P450 2C9 enzymes. Elimination: 57% are primarily excreted in feces and 27% excreted in urine. Half-Life: 11.2 hours. INDICATION INDICATIVE FOR: 1. Relief the signs of rheumatoid arthritis and osteoarthritis. 2. Treatment of acute pain and dysmenorrhea, 3. Reduction of polyp formation in Familial Adenomatous Polyposis (FAP). CONTRAINDICATION CONCENTRATIONS: Contraindicated in patients with: 1. Hypersensitivity to colecoxib 2. severe hepatic impairment 3. asthmatic patient with aspirin triad 4. anemia 5. concurrent use of diuretics and ACE inhibitors 6. advanced renal disease 7. pregnancy in third trimester 8. lactation PRECAUTIONS: Use cautiously in patients who/with: 1. weight less than 50 kg ADVERSE EFFECTS MOST COMMON: Body as a whole: Peripheral edema and back pain. GI: diarrhea, abdominal pain, dyspepsia, nausea and flatulence. CNS: Headache, insomnia and dizziness. Respiratory: Rhinitis, sinusitis and pharyngitis, upper respiratory infection. Skin: Rash NURSING RESPONSIBILITIES BEFORE: 1. Assess patients range of motion, degree of swelling, and pain in affected joints before and periodically throughout therapy 2. Assess patient for allergy to sulfonamides, aspirin, or NSAIDS. Patients with these allergies should not receive celecoxib 3. Monitor fluid retention and edema especially in those with a history of high blood pressure or CHF 4. Monitor closely level of lithium when two drugs are given concurrently. 5. Lab test: periodically monitor Hct and Hgb, BUN, creatinine, and serum electrolytes. DURING: 1. Instruct patient to take celecoxib exactly as directed. Do not take more than prescribed dose. Increasing doses does not appear to increase effectiveness 2. May be administered without regard to meals. 3. Encourage bed rest 4. Instruct pt./SO to have small frequent feeding AFTER:

    Celecoxib
    TRADE NAME: Celebrex MAX. and MIN. DOSE:

    AVAILABILITY: 100 mg and 200 mg capsules ROUTE: Oral: - Give 2 hours before and after magnesium or aluminum-containing antacids.

    2.
    3. 4.

    moderate hepatic impairment aspirin use renal insufficiency; with history of peptic ulcer disease asthmatic pregnancy in first, second trimester and third trimester kidney disease heart failure retention DRUG INTERACTIONS:

    5.
    6.

    1.

    7. 8.
    9.

    1.Concomitant use of celecoxib


    with aspirin or other NSAIDs may increase the occurrence of stomach and intestinal ulcers.

    10. hypertension, fluid

    Advise patient to notify health care professional promptly if signs or symptoms of GI toxicity (abdominal pain, black stools), skin rash, unexplained weight gain, edema occurs 2. Patient should discontinue celecoxib and notify health care professional if signs and symptoms of hepatotoxicity (nausea, fatigue, lethargy, pruritus, jaundice, upper right quadrant tenderness, flu-like symptoms) occur 3. Do not breast feed while taking celecoxib

    2.Fluconazole (Diflucan)increases the concentration of celecoxib in the body by preventing the elimination of celecoxib in the liver Lithium (Eskalith)- Celecoxib increases the concentration of the drug in the blood by 17% and may promote lithium toxicity SOURCE: http://www.nursetopic.com/2011/ 08/celecoxib.html

    SOURCE: http://www.nursetopic.com/2011/08/c elecoxib.html

    SOURCE: http://www.nursetopic.com/2 011/08/celecoxib.html

    SOURCE: http://www.nursetopic.com/2011/08/c elecoxib.html

    SOURCE: http://www.nursetopic.com/2011/ 08/celecoxib.html

    SOURCE: http://www.nursetopic.com/2011/0 8/celecoxib.html

    SOURCE:

    http://www.nursing-nurse.com/drugstudy-celebrex-173/ http://bsnurse.com/celebrex/

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