Chapter 6 Mood Disorders
Chapter 6 Mood Disorders
Chapter 6 Mood Disorders
Mood disorders
• Affect : short –lived emotional response to an idea
/event
• Mood : sustained & pervasive emotional response
which colors the whole psychic life
Classification
Ⅰ. Manic episode
Ⅱ. Depressive episode
Ⅲ. Bipolar mood (affective) disorders
Ⅳ. Recurrent depressive disorders
Ⅴ. Persistent mood disorder (cyclothymia ,dysthymia)
Ⅵ.Other mood disorders(mixed affective episode &
recurrent brief depressive disorder)
ⅰ.Elevated,expansive or irritable mood
ⅱ.Psychomotor activity goal- oriented
ⅲ.Speech & thought
ⅳ.Goal-directed Activity
ⅴ.Other features sleeping
ⅵ.Absence of underlying organic causes
ⅰ. Euphoria hypomania
ⅱ. Elation confidence & enjoyment
ⅲ.Exaltation delusion of grandeur
ⅳ. Ecstasy rapture of blissfullness
delirious / stuporous mania
ⅰ.Depressed mood
ⅱ.Depressive ideation /cognition
ⅲ.Psychomotor activity < 40y
ⅳ.Physical symptoms hypochondriacal (ill)
ⅴ.Biological functions sleeping
ⅵ.Psychotic features delusion
ⅶ.Suicide
ⅷ.Absence of underlying organic causes
BipolarⅠ & Ⅱ
ⅰ. Hypomanic
ⅱ. Manic without psychotic symptoms
ⅲ. Manic with psychotic symptoms
ⅳ. Mild or moderate depression
ⅴ. Severe depression , wtihout psychotic symptoms
ⅵ. Severe depression , wtih psychotic symptoms
ⅶ. mixed
ⅷ. In remission
ⅰ. mild
ⅱ. moderate
ⅲ. Severe,without psychotic symptoms
ⅳ. Severe,with psychotic symptoms
ⅴ. In remission
Courses & prognosis
• Bipolar mood disorders early onset than recurent
depressive
• Manic episode 3~4 mon 2w
• Depressive episode 4~6mon 6~8w
• Unipolar depression longer than bipolar
depression
• Rapid cyclers 4episodes/y F 70·80%
(Bipolar )
Etiology
• Ⅰ. Biological theories
• Ⅱ. Psychosocial theories
Biological theories
• Genetic hypothesis monozygotic 65% ,46% dizygotic
• Biochemical theories
• Neuroendocrine
• Sleeping studies
• Brain imaging
Psychosocial theories
• Psychoanalytic theories self-love
• Stress
• Cognitive & behavioral theories
Depressive negative cognition, learned helplessness
Anger directed inward
Differential diagnosis
• Organic , drug-induced
• Acute & transient psychotic disorders/
schizoaffective disorder & schizophrenia
obsessive compulsive disorder
Management
Ⅰ. Somatic treatment
Ⅱ. Psychosocial treatment
Somatic treatment
• Antidepressants
• ECT(Electroconvulsive therapy)
• Lithium (Li) manic episode
• Antipsychotics
• Other mood stabilizers
• Other treatment
Electroconvulsive therapy
• psychosis or a risk of suicide
• major depression :manic delirium, or catatonia
• schizoaffective or schizophreniform disorder
Common antipsychotics
First generation
* Butyrophenones
Haloperidol (Haldol) (Serenace) Droperidol
(Droleptan)
* Phenothiazines
*Thioxanthenes
Chlorprothixene
Flupenthixol (Depixol and Fluanxol)
Thiothixene (Navane)
Zuclopenthixol (Clopixol & Acuphase)
Common antipsychotics 2nd &3rd generation