Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                
Scribd Logo
Upload

Welcome to Scribd!

  • 97 views

    Nephrotic

    Uploaded by

    sangheeta
    The document summarizes several kidney diseases including their most frequent clinical presentations, pathogenesis, age groups affected, and treatment outcomes. Some of the diseases discussed include minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, diabetic nephropathy, Alport syndrome, acute post-streptococcal glomerulonephritis, IgA nephropathy, endocarditis-related glomerulonephritis, Wegener's granulomatosis, Goodpasture's syndrome, and membranoproliferative glomerulonephritis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd

    Nephrotic

    Uploaded by

    sangheeta
    97 views8 pages
    The document summarizes several kidney diseases including their most frequent clinical presentations, pathogenesis, age groups affected, and treatment outcomes. Some of the diseases discussed include minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, diabetic nephropathy, Alport syndrome, acute post-streptococcal glomerulonephritis, IgA nephropathy, endocarditis-related glomerulonephritis, Wegener's granulomatosis, Goodpasture's syndrome, and membranoproliferative glomerulonephritis.

    Original Description:

    classification

    Original Title

    nephrotic

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document summarizes several kidney diseases including their most frequent clinical presentations, pathogenesis, age groups affected, and treatment outcomes. Some of the diseases discussed include minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, diabetic nephropathy, Alport syndrome, acute post-streptococcal glomerulonephritis, IgA nephropathy, endocarditis-related glomerulonephritis, Wegener's granulomatosis, Goodpasture's syndrome, and membranoproliferative glomerulonephritis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    97 views8 pages

    Nephrotic

    Uploaded by

    sangheeta
    The document summarizes several kidney diseases including their most frequent clinical presentations, pathogenesis, age groups affected, and treatment outcomes. Some of the diseases discussed include minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, diabetic nephropathy, Alport syndrome, acute post-streptococcal glomerulonephritis, IgA nephropathy, endocarditis-related glomerulonephritis, Wegener's granulomatosis, Goodpasture's syndrome, and membranoproliferative glomerulonephritis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 8

    Disease

    Most Frequent Clinical Presentation

    Pathogenesis

    Age Group Affected #1 cause of Nephrotic Syndrome in children, esp. boys younger than 6 yrs. old.

    Treatment and Outcome -Responds well to corticosteroids. - No progression into chronic renal failure -Does not respond to corticosteroids. -Leads to renal failure.

    Minimal Selective Change Disease proteinuria (Lipoid (Albumin) Nephrosis)

    Loss of foot processes Loss of GBM polyanionic sites Appearance of villi on epithelial cells Idiopathic Lower renal mass (in obese) 2 causes: heroin use, HIV

    Focal Segmental Glomerular Sclerosis

    Non-selective proteinuria Hypertension Microscopic hematuria

    Majority occur in older children. Also occurs in adults.

    Disease

    Most Frequent Clinical Presentation Persistent proteinuria

    Pathogenesis

    Age Group Affected #1 cause of Nephrotic syndrome in adults

    Treatment and Outcome -Benefit of corticosteroids is unknown.

    Membranous Nephropathy (Glomerulo nephritis)

    Idiopathic 2 causes: carcinomas, SLE, hepatitis, Diabetes Mellitus, thyroiditis, drugs.

    Diabetic Nephropathy (Diabetic Glomerulo sclerosis)

    Proteinuria Diabetic No hematuria microangiopathy Thickened B.M. Massive mesangial growth "Kimmelstiel Wilson" nodular glomerulosclerosis Diffuse glomerulosclerosis

    Diabetics

    -Progresses to renal failure

    Disease

    Most Frequent Clinical Presentation Recurrent hematuria before age 20 Hypertension Deafness and ocular problems Recurrent hematuria Most frequent cause of asymptomatic hematuria.

    Pathogenesis

    Age Group Affected Symptoms appear before age 20

    Treatment and Outcome -Progresses to renal failure

    Alport Syndrome (Hereditary Nephritis)

    Structural defect in Collagen IV leads to leaky basement membranes.

    Benign Familial Hematuria (Thin B.M. Disease)

    Reduced thickness of glomerular B.M.

    Disease

    Most Frequent Clinical Presentation Acute nephritis Abrupt oliguria, hematuria, facial edema, hypertension.

    Pathogenesis

    Age Group Affected Common renal disease in childhood

    Treatment and Outcome -Return to normal in 8 weeks. Complete recovery without treatment (especially in kids) within 3 years.

    Acute (PostStreptococcal) Glomerulo nephritis

    Immune-complex mediated (Type-III hypersensitivity) Occurs after Streptococcal pharyngitis or Hepatitis-B High ASO-titer, low C3 Anti ds-DNA antibodies.

    SLE Nephropathy

    Degree of kidney involvement correlates with prognosis in SLE.

    Disease

    Most Frequent Clinical Presentation IgA Nephropathy (Berger's Disease): Most common primary Glomerulo nephritis

    Pathogenesis

    Age Group Affected Young men 15-30

    Treatment and Outcome

    Focal Segmental Glomerulo nephritis

    Circulating IgA + fibronectin (due to chronic liver disease)

    HenochSchonlein Purpura

    Same as above, Mesangial cell Children plus proliferation, more systemic serious than above. disease: purpura of extremities, arthritis, colicky abdominal pain.

    Disease

    Most Frequent Pathogenesis Clinical Presentation S. Aureus Subepithelial immune deposits

    Age Group Treatment Affected and Outcome Kidney disease resolves when infection is cured.

    Endocarditis

    Rapidly Progressive Crescentic Glomerulo nephritis

    Wegener's: kidney + upper respiratory tract. Anuria Oliguria

    Inflamed glomerular capillaries ANCA (+)

    Must be treated or it will go to renal failure within weeks.

    Disease

    Pathogenesis

    Age Group Affected

    Treatment and Outcome

    Goodpasture Syndrome Lung (hemoptysis) + (Anti-BM Antibody kidneys (hematuria) Disease)

    Anti-B.M. Males 25-30 antibodies, against TypeIV collagen

    Membranoproliferative Glomerulonephritis (Mesangiocapillary Glomerulonephritis)

    B.M. thickening and cellular proliferation Mesangial expansion makes glomerular B.M. appear as though it were in two layers

    You might also like