Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                
Scribd Logo
Upload

Welcome to Scribd!

  • 159 views

    Pharmacokinetics: - Not Bound To Plasma Proteins - Is Eliminated by The Kidneys and Liver - T1/2 5 Minutes

    Uploaded by

    ganot
    Oxytocin is a drug used to induce labor that is not bound to plasma proteins, is eliminated by the kidneys and liver with a half-life of 5 minutes. It acts through G protein-coupled receptors and phosphoinositide-calcium second messenger system to contract uterine smooth muscle and stimulate prostaglandin and leukotriene release, augmenting uterine contractions. Small doses increase contraction frequency and force while higher doses produce sustained contractions. It is used to induce labor by binding uterine receptors and activating a phosphatidyl inositol pathway, releasing calcium and causing uterine contractions. Uterine contractions occur within 3-5 minutes of intramuscular or intravenous administration, reaching steady levels after 40

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Pharmacokinetics: - Not Bound To Plasma Proteins - Is Eliminated by The Kidneys and Liver - T1/2 5 Minutes

    Uploaded by

    ganot
    159 views7 pages
    Oxytocin is a drug used to induce labor that is not bound to plasma proteins, is eliminated by the kidneys and liver with a half-life of 5 minutes. It acts through G protein-coupled receptors and phosphoinositide-calcium second messenger system to contract uterine smooth muscle and stimulate prostaglandin and leukotriene release, augmenting uterine contractions. Small doses increase contraction frequency and force while higher doses produce sustained contractions. It is used to induce labor by binding uterine receptors and activating a phosphatidyl inositol pathway, releasing calcium and causing uterine contractions. Uterine contractions occur within 3-5 minutes of intramuscular or intravenous administration, reaching steady levels after 40

    Original Description:

    oxytocin

    Original Title

    F. Oxytocin

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Oxytocin is a drug used to induce labor that is not bound to plasma proteins, is eliminated by the kidneys and liver with a half-life of 5 minutes. It acts through G protein-coupled receptors and phosphoinositide-calcium second messenger system to contract uterine smooth muscle and stimulate prostaglandin and leukotriene release, augmenting uterine contractions. Small doses increase contraction frequency and force while higher doses produce sustained contractions. It is used to induce labor by binding uterine receptors and activating a phosphatidyl inositol pathway, releasing calcium and causing uterine contractions. Uterine contractions occur within 3-5 minutes of intramuscular or intravenous administration, reaching steady levels after 40

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    159 views7 pages

    Pharmacokinetics: - Not Bound To Plasma Proteins - Is Eliminated by The Kidneys and Liver - T1/2 5 Minutes

    Uploaded by

    ganot
    Oxytocin is a drug used to induce labor that is not bound to plasma proteins, is eliminated by the kidneys and liver with a half-life of 5 minutes. It acts through G protein-coupled receptors and phosphoinositide-calcium second messenger system to contract uterine smooth muscle and stimulate prostaglandin and leukotriene release, augmenting uterine contractions. Small doses increase contraction frequency and force while higher doses produce sustained contractions. It is used to induce labor by binding uterine receptors and activating a phosphatidyl inositol pathway, releasing calcium and causing uterine contractions. Uterine contractions occur within 3-5 minutes of intramuscular or intravenous administration, reaching steady levels after 40

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 7

    Pharmacokinetics

    not bound to plasma proteins


    is eliminated by the kidneys and liver
    T1/2 5 minutes.
    Katzung, B. G., Masters, S. B., & Trevor, A. J. (2012). Basic &
    clinical pharmacology. New York: McGraw-Hill Medical.

    Pharmacodynamics
    acts through G protein-coupled receptors and
    the
    phosphoinositide-calcium
    secondmessenger system
    contract uterine smooth muscle, stimulates
    the release of prostaglandins and leukotrienes
    that augment uterine contraction.
    small doses increases both the frequency
    and the force of uterine contractions
    higher doses produces sustained
    contraction.
    Katzung, B. G., Masters, S. B., & Trevor, A. J. (2012). Basic & clinical
    pharmacology. New York: McGraw-Hill Medical.

    The general uses of these Oxytocin drugs would


    include induction of labour .
    at the time delivery,
    a. Oxytocin binds to the receptors present in the
    myometrium
    b. activates the pathway of hydrolysis of
    phoshotidyl inositol and diacyl glycerol
    This activation causes the release of intracellular
    Calsium which causes contraction of the uterus .
    Kabilan A. J. Pharm. Sci. & Res. Vol. 6(4), 2014, 220-223

    Uterine contractions are seen after 3-5 minutes and


    approx 1 minute of admistration through intramuscular
    and intravenous routes respectively.
    A steady state of the drug is reached after 40 mins of
    parenteral route of administration. It is distributed
    throughout extracellular fluid compartment of the
    mother; small amounts may cross the placental barrier
    and reach foetus. Metabolism takes place rapidly via the
    liver and plasma by the enzyme oxytocinase a few steps
    of metabolism also takes place via mammary gland. It
    has a half-life of 1-5 minute.
    Kidney and liver help in the elimination of Oxytocin drugs
    unchanged form of this drug is rarely excreted in urine.

    Kabilan A. J. Pharm. Sci. & Res. Vol. 6(4), 2014, 220-223

    Intravenous vs
    Intramuscular
    Using a radioinimunoassay for oxytocin, circulating levels of the Oxytocin were
    measured following intravenous and intramuscular administration of Syntometrine.
    1. After intramuscular injection oxytocin appeared in the circulation in as little as
    30 seconds and continued to be detectable at levels around 25 pg. per ml. for
    up to 60 minutes.
    2. After intravenous injection there was a rapid rise to a peak of 530 pg. per ml. at
    one minute.
    The subsequent decay showed a bi-exponential pattern, and yielded an average
    half-life of 3 minutes for the initial rapid phase of disappearance.

    D. Gibbens et al. The Circulating Levels Of Oxytocin Following Intravenous


    And Intramuscular Administration Of Syntometrine. The Journal of
    Obstetrics and Gynaecology ojthe British Commonwealth. July 1972. Vol. 79. pp.
    644-646.

    D. Gibbens et al. The Circulating Levels Of Oxytocin Following Intravenous And


    Intramuscular Administration Of Syntometrine. The Journal of Obstetrics and
    Gynaecology ojthe British Commonwealth. July 1972. Vol. 79. pp. 644-646.

    D. Gibbens et al. The Circulating Levels Of Oxytocin Following Intravenous And


    Intramuscular Administration Of Syntometrine. The Journal of Obstetrics and Gynaecology
    ojthe
    British
    Commonwealth.
    July
    1972.
    Vol.
    79.
    pp.
    644-646.

    You might also like