Metabolic Bone Disease

Metabolic Bone Disease
DEFINITION
Metabolic bone diseases are disorders of bone

strength usually caused by abnormalities of minerals
such as calcium or phosphate, vitamin D, bone mass
or bone structure. The most common metabolic bone
disorder is osteoporosis.
Minerals; serum concentration

Calcium (Ca2+); 2.2-2.6 mM (total)
Phosphate (HPO42-); 0.7-1.4 mM
Magnesium (Mg2+); 0.8-1.2 mM
Organ systems that play an import role in Ca2+
metabolism
Skeleton
GI tract
Kidney
Calcitropic Hormones
Parathyroid hormone (PTH)
Calcitonin (CT)
Vitamin D (1,25 dihydroxycholecalciferol)
Parathyroid hormone related protein (PTHrP)
BONE
Inorganic (67%)
Hydroxyapatite 3 Ca10(PO4)6(OH)2
There is some amorphous calcium phosphate
Organic (33%) component is called osteoid

Type I collagen (28%)
Non-collagen structural proteins (5%)
Proteoglycans
Sialoproteins
Gla-containing proteins (gamma carboxyglutamate)
Phosphoproteins
Bone specific proteins: osteocalcin, osteonectin
Growth factors and cytokines (Trace)
Bone undergoes continuous turnover or remodelling throughout

life
About 20% of bone is undergoing remodelling at any one time
Osteoblast and osteoclast function

Osteoblasts
Bone formation
Synthesis of matrix proteins
Type I collagen
Osteocalcin
Others
Mineralization
Activation of osteoclasts via RANKL production
Osteoclasts
Bone resorption
Degradation of proteins by enzymes
Acidification
RANK is activated by RANKL, and this leads to cells
differentiation to osteoclasts
BONE REMODELLING
Osteoclasts dissolve bone

Large multinucleated giant cells
Osteoblasts produce bone
Have receptors for PTH, CT, Vitamin D, cytokines, and
growth factors
Main product is collagen
When osteoblasts become encased in bone, they
become osteocytes
OSTEOPOROSIS- ACQUIRED DISEASES OF BONE
Osteoporosis is an acquired condition characterized

by reduced bone mass, leading to bone fragility and
susceptibility to fractures.
The bone loss may be confined to certain bones or

regions, as in disuse osteoporosis of a limb, or be
generalized, involving the entire skeleton.
Generalized osteoporosis may be primary or occur

secondary to a large variety of insults, including
metabolic diseases, vitamin deficiencies, and drug
exposures
Primary forms of osteoporosis are most common and

may be associated with aging (senile osteoporosis) or
the postmenopausal state in women.
The drop in estrogen following menopause tends to

increase the loss of bone that occurs with aging,
placing older women at high risk of osteoporosis
relative to men.
The risk of osteoporosis with aging is related to the

peak bone mass earlier in life, which is influenced by
genetic, nutritional, and environmental factors.
Bone mass peaks during young adulthood; the

greater the peak bone mass, the greater the delay in
onset of osteoporosis.
PATHOGENESIS
Osteoporosis occurs when the dynamic balance
between bone formation by osteoblasts and bone
resorption by osteoclasts tilts in favour of resorption.
Age-related changes. With increasing age, the

replicative and matrix production activities of
osteoblasts progressively diminish. The various
growth factors deposited in the extracellular matrix
also diminish with time.
Hormonal influences. The decline in estrogen levels

associated with menopause correlates with an
acceleration of cortical bone and trabecular
(cancellous) bone loss.
It is therefore not surprising that roughly half of

postmenopausal women will suffer an osteoporotic
fracture (compared with 2% to 3% of men of
comparable age).
It appears that the postmenopausal drop in estrogen

leads to increased cytokine production (especially IL-1,
IL-6, and TNF), presumably from cells in the bone.
These stimulate RANKRANK ligand activity and

suppress OPG production.
There is some compensatory osteoblastic activity, but

it is inadequate to keep pace with osteoclastic bone
resorption. While estrogen replacement can ameliorate
some of the bone loss, such therapy is increasingly
associated with cardiovascular risks.
Physical activity. Because mechanical forces stimulate

bone remodelling, reduced physical activity increases
bone loss. Decreased physical activity in older
persons also contributes to senile osteoporosis.
Calcium nutritional state. A majority of adolescent

girls (but not boys) have insufficient dietary calcium.
Unfortunately, this calcium deficiency occurs during a
period of rapid bone growth. As a result, girls typically
do not achieve the peak bone mass that could be
otherwise expected and are accordingly more likely to
develop clinically significant osteoporosis at an earlier
age than their male counterparts.
Secondary causes of osteoporosis. These include

prolonged glucocorticoid therapy, which increases
bone resorption and reduces bone synthesis.
Cigarette smoking and excess alcohol also can result
in reduced bone mass.
The clinical outcome with osteoporosis depends on

which bones are involved. Thoracic and lumbar
vertebral fractures are extremely common, leading
to loss of height and various deformities, including
kyphoscoliosis, which can compromise respiratory
function. Pulmonary embolism and pneumonia are
common complications of fractures of the femoral
neck, pelvis, or spine and result in as many as
50,000 deaths annually.
Osteoporosis prevention and treatment begin with

adequate dietary calcium intake, vitamin D
supplementation, and a regular exercise regimen
starting before the age of 30to maximize the peak
bone mass. Calcium and vitamin D supplements later in
life can also modestly reduce bone loss. Pharmacologic
treatments include use of antiresorptive and
osteoanabolic agents. The antiresorptive agents, such as
bisphosphonates, calcitonin, estrogen, and denosumab,
decrease bone resorption by osteoclasts. The main
anabolic agent is parathyroid hormone or an analogue,
given in amounts that stimulate osteoblastic activity.
OSTEOGENESIS IMPERFECTA
Osteogenesis imperfecta (OI), also known as brittle bone

disease, is actually a group of genetic disorders caused
by defective synthesis of type I collagen.
Because type I collagen is a major component of
extracellular matrix in other parts of the body, there are
also numerous extraskeletal manifestations (affecting
skin, joints, teeth, and eyes, for example).
The mutations underlying OI characteristically involve the
coding sequences for 1 or 2 chains of type I collagen.
Because collagen synthesis and extracellular export
require formation of a complete and intact triple helix,
any primary defect in a collagen chain tends to disrupt
the entire structure and results in its premature
degradation (an example of a dominant negative
mutation)
As a consequence, most defects manifest as

autosomal dominant disorders and may be
associated with severe malformations. There is,
however, a broad spectrum of severity, and
mutations that result in qualitatively normal collagen
but at only reduced levels generally have milder
manifestations.
The classic finding of blue sclerae in type I OI is

attributable to decreased scleral collagen content;
this deficit causes a relative transparency that allows
the underlying choroid to be seen. Hearing loss can
be related to conduction defects in the middle and
inner ear bones, and small misshapen teeth are a
result of dentin deficiency.
OSTEOPETROSIS
Osteopetrosis is a group of rare genetic disorders

characterized by defective osteoclast-mediated bone
resorption. Osteopetrosis (literally, bone-that-is-likestone disorder) is an appropriate name, since the
bones are dense, solid, and stone-like.
The defects that cause osteopetrosis are categorized

into those that disturb osteoclast function and those
that interfere with osteoclast formation and
differentiation.
The precise nature of the osteoclast dysfunction is

unknown in many cases. Nevertheless, in some
cases the abnormalities have been identified. These
include carbonic anhydrase II deficiency, proton
pump deficiency and chloride channel defect, all of
which interfere with the ability of osteoclasts to
resorb bone.
Besides fractures, patients with osteopetrosis

frequently have cranial nerve palsies (due to
compression of nerves within shrunken cranial
foramina), recurrent infections because of reduced
marrow size and activity, and hepatosplenomegaly
caused by extramedullary hematopoiesis resulting
from reduced marrow space.
PAGETS DISEASE(OSTEITIS DEFORMANS)
This unique skeletal disease is characterized by

repetitive episodes of frenzied, regional osteoclastic
activity and bone resorption (osteolytic stage),
followed by exuberant bone formation (mixed
osteoclastic-osteoblastic stage), and finally by an
apparent exhaustion of cellular activity
(osteosclerotic stage). The net effect of this process
is a gain in bone mass; however, the newly formed
bone is disordered and weak, so bones may become
enlarged and misshapen.
Paget disease usually presents in mid- to late adulthood
CLINICAL COURSE
The clinical findings depend on the extent and site of the
disease.
Elevations in serum alkaline phosphatase and increased
urinary excretion of hydroxyproline reflect exuberant bone
turnover.
In some patients, the early hypervascular bone lesions
cause warmth of the overlying skin and subcutaneous
tissue. With extensive polyostotic disease,
hypervascularity can result in high-output congestive
heart failure. In the proliferative phase of the disease
involving the skull, common symptoms attributable to
nerve impingement include headache and visual and
auditory disturbances. Vertebral lesions cause back pain
and may be associated with disabling fractures and nerve
root compression.
Brittle long bones in particular are

subject to chalkstick fractures.
Most patients have mild symptoms that

are readily controlled with
bisphosphonates (alendronate,
risedronate), drugs that interfere with
bone resorption
RICKETS AND OSTEOMALACIA
Both rickets and osteomalacia are manifestations of

vitamin D deficiency or its abnormal metabolism. The
fundamental defect is an impairment of mineralization and
a resultant accumulation of unmineralized matrix.
This contrasts with osteoporosis, in which the mineral

content of the bone is normal and the total bone mass is
decreased.
Rickets refers to the disorder in children, in which it

interferes with the deposition of bone in the growth plates.
Osteomalacia is the adult counterpart, in which bone

formed during remodelling is undermineralized, resulting
in predisposition to fractures.
Clinical Features
Rickets in children prior to closing of epiphyses
Skull deformities craniotabes, frontal bossing
Rachitic rosary over growth of cartilage at
costochondral junction
Pectus carinatum, lumbar lordosis, bowing of legs
Osteomalacia adults
Bone pain, fractures
Xray radiolucency of bone
Lab: low serum Ca, low serum PO, High Alkaline
phosphatase

Metabolic Bone Disease

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Metabolic Bone Disease

Metabolic bone diseases are disorders of bone

Minerals; serum concentration

Organic (33%) component is called osteoid

Growth factors and cytokines (Trace)

Bone undergoes continuous turnover or remodelling throughout

About 20% of bone is undergoing remodelling at any one time

Osteoblast and osteoclast function

Osteoclasts dissolve bone

OSTEOPOROSIS- ACQUIRED DISEASES OF BONE

Osteoporosis is an acquired condition characterized

The bone loss may be confined to certain bones or

Generalized osteoporosis may be primary or occur

Primary forms of osteoporosis are most common and

The drop in estrogen following menopause tends to

The risk of osteoporosis with aging is related to the

Bone mass peaks during young adulthood; the

Age-related changes. With increasing age, the

Hormonal influences. The decline in estrogen levels

It is therefore not surprising that roughly half of

It appears that the postmenopausal drop in estrogen

These stimulate RANKRANK ligand activity and

There is some compensatory osteoblastic activity, but

Physical activity. Because mechanical forces stimulate

Calcium nutritional state. A majority of adolescent

Secondary causes of osteoporosis. These include

The clinical outcome with osteoporosis depends on

Osteoporosis prevention and treatment begin with

Osteogenesis imperfecta (OI), also known as brittle bone

As a consequence, most defects manifest as

The classic finding of blue sclerae in type I OI is

Osteopetrosis is a group of rare genetic disorders

The defects that cause osteopetrosis are categorized

The precise nature of the osteoclast dysfunction is

Besides fractures, patients with osteopetrosis

PAGETS DISEASE(OSTEITIS DEFORMANS)

This unique skeletal disease is characterized by

Paget disease usually presents in mid- to late adulthood

Brittle long bones in particular are

Most patients have mild symptoms that

RICKETS AND OSTEOMALACIA

Both rickets and osteomalacia are manifestations of

This contrasts with osteoporosis, in which the mineral

Rickets refers to the disorder in children, in which it

Osteomalacia is the adult counterpart, in which bone

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