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    Liposomes - : A Novel Drug Delivery System

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    nivethita
    Liposomes are spherical vesicles made of phospholipid bilayers that can be used to deliver drugs, vaccines, and other substances in the body. They provide advantages over traditional drug delivery such as lowering toxicity and allowing targeted delivery. Liposomes are prepared using methods that involve drying lipids and rehydrating them in aqueous solution. Common phospholipids used include phosphatidylcholine, cholesterol, and phosphatidylethanolamine. Liposomes find applications in changing the absorption and biodistribution of drugs. They can also protect drugs from degradation and reduce harmful side effects.

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    Liposomes - : A Novel Drug Delivery System

    Uploaded by

    nivethita
    110 views20 pages
    Liposomes are spherical vesicles made of phospholipid bilayers that can be used to deliver drugs, vaccines, and other substances in the body. They provide advantages over traditional drug delivery such as lowering toxicity and allowing targeted delivery. Liposomes are prepared using methods that involve drying lipids and rehydrating them in aqueous solution. Common phospholipids used include phosphatidylcholine, cholesterol, and phosphatidylethanolamine. Liposomes find applications in changing the absorption and biodistribution of drugs. They can also protect drugs from degradation and reduce harmful side effects.

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    Liposomes )

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    Liposomes are spherical vesicles made of phospholipid bilayers that can be used to deliver drugs, vaccines, and other substances in the body. They provide advantages over traditional drug delivery such as lowering toxicity and allowing targeted delivery. Liposomes are prepared using methods that involve drying lipids and rehydrating them in aqueous solution. Common phospholipids used include phosphatidylcholine, cholesterol, and phosphatidylethanolamine. Liposomes find applications in changing the absorption and biodistribution of drugs. They can also protect drugs from degradation and reduce harmful side effects.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    110 views20 pages

    Liposomes - : A Novel Drug Delivery System

    Uploaded by

    nivethita
    Liposomes are spherical vesicles made of phospholipid bilayers that can be used to deliver drugs, vaccines, and other substances in the body. They provide advantages over traditional drug delivery such as lowering toxicity and allowing targeted delivery. Liposomes are prepared using methods that involve drying lipids and rehydrating them in aqueous solution. Common phospholipids used include phosphatidylcholine, cholesterol, and phosphatidylethanolamine. Liposomes find applications in changing the absorption and biodistribution of drugs. They can also protect drugs from degradation and reduce harmful side effects.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 20

    LIPOSOMES - A Novel

    Drug Delivery System

    11/05/2017 1
    INTRODUCTION
    Liposomes are the simple microscopic vesicles in which
    aqueous layer is enclosed by phospho lipid bilayers that
    are used to transfer vaccines ,drugs ,enzymes and other
    substances to targetcells or organs

    Structually ,liposomes are concentric bilayerd vesicles in


    which an aqueous volume is entirely enclosed by a
    membraneous lipid bilayer mainly composed of natural or
    synthetic phospholipids.

    Can be produced from cholesterols, non toxic surfactants,


    sphingolipids, glycolipids, long chain fatty acids and even
    membrane proteins.

    . 2
    Structure Of Liposome

    . 3
    COMPOSITION

    Phospholipids:
    Dilauryl phosphotidyl choline (DLPC), Dimyristoyl phosphotidyl choline
    (DMPC), Dipalmitoy phosphotidyl choline (DPPC), Distearoyl
    phosphotidyl choline (DSPC), Dioleolyl phosphotidyl choline (DOPC),
    Dilauryl phosphotidyl glycerol (DLPG), Distearoyl phosphotidyl serine
    (DSPS).

    Cholesterol:
    Act as intercalator with phospholipids molecules.
    Restrict the confirmational changes of lipids.
    Membrane stabilizer.

    . 4
    ADVANTAGES

    Non-toxic.
    Biodegradable.
    Non-immunogenic.
    Lowers systemic toxicity.
    Targeted delivery.
    Protection of sensitive drug molecules.
    Enhance drug solubilisation ( Amphoterecin,
    Cyclosporins).
    Improved pharmacokinetic effects.

    . 5
    DISADVANTAGES
    Leakage of encapsulated drug during storage.

    Short half-life.

    Batch to batch variation.

    Difficult in large scale manufacturing and sterilization.

    Production cost is high.

    Once administered, liposomes can not be removed.

    Some times phospholipids undergoes hydrolysis and


    oxidation reactions
    . 6
    COMMONLY USED
    PHOSPHOLIPIDS PHOSPHATIDYL
    CHOLINE

    PHOSPHATIDYL
    NATURAL
    ETHANOLAMINE

    PHOSPHATIDYL
    SERINE
    COMMONLY USED
    PHOSPHOLIPIDS
    DIOLEOYL
    PHOSPHATIDYL
    CHOLINE

    DISTEAROYL
    SYNTHETIC PHOSPHOTIDYL
    CHOLINE

    DIOLEOYL
    PHOSPHATIDYL
    ETHANOLAMINE
    TYPES

    . 8
    BASED ON STRUCTURE

    . 8
    BASED ON PREPARATION
    METHOD

    . 10
    . 11
    General Method Of Liposome Formation

    All the methods of preparing liposomes involves 3 to 4 steps.

    Drying down lipids from organic solvents

    Dispersion of lipids in aqueous media

    Purification of resultant liposomes

    Analysis of final product


    PREPARATION METHODS

    METHODS OF LIPOSOME
    PREPARATION

    ACTIVE OR REMOTE LOADING


    PASSIVE LOADING Certain types of compounds with
    ionizable groups and those with
    Involves loading of the entrapped
    both lipid and aqueous solubility ,
    agents before or during the
    can be introduced into the
    manufacturing procedure
    liposomes after the formation of
    the intact vesicles

    . 13
    PREPARATION PROCESS

    . 14
    Classes of Liposomes

    CONVENTIONAL LONG CIRCULATING

    IMMUNO CATIONIC
    USES OF LIPOSOMES
    PHARMACOKINETICS - Efficacy And Toxicity

    Changes the absorbance and bio distribution

    Deliver drug in desired form

    Multidrug resistance

    PROTECTION

    Decrease harmful side effects

    Change where drug accumulates in the body

    Protects drug

    . 16
    Problems With Liposomal Preparation Of Drugs

    Lacklongtermstability(shortshelflife)

    Physicalandchemicalinstability

    FreezedryandpHadjustment

    LowPayLoadPoorEncapsulation

    Drugsanddrugswithoutoppositecharge

    Modifications

    . 17
    EXAMPLES

    . 18
    References:

    Y. Sultana., Liposomal Drug Delivery Systems: An Update Review. ,


    Current Drug Delivery 2007, 4, 297-305.
    Sharma Shailesh, Sharma Neelam, Kumar Sandeep, Gupta GD.,
    Liposomes: Areview., Journal of Pharmacy Research 2009, 2(7),1163-
    1167.
    Mohammad Riaz., Liposomes Preparation Methods., Pakistan Journal
    of Pharmaceutical Sciences Vol.19(1), January 1996, 65-77.
    MU Uhumwangho and RS Okor., Current trends in the production and
    biomedical applications of liposomes: a review ., JMBR June 2005 Vol.
    4(1) 9-21.
    http://www.biopharminternational.com/biopharm/data/articlestandar
    d/biopharm/032002/7278/article.pdf., web, 28.01.2012
    http://www.ias.ac.in/jarch/currsci/68/00000742.pdf.,web, 28.01.2012
    D.D. Lasic., Applications of Liposomes., Handbook of Biological
    Physics., Elsevier Science B.V.., 1995., Vol.1., 1-29

    . 19
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