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    Vitamin Deficiency Diseases - B6

    Uploaded by

    Dr. Janarthanan V
    This document discusses vitamin B6 (pyridoxine) and folate deficiency diseases. It provides information on recommended daily intake of vitamin B6, food sources, roles as a coenzyme, symptoms of deficiency including seborrhea and neuropathy, etiology such as alcoholism and medication interactions, clinical picture including anemia, lab diagnosis of low plasma pyridoxine levels, treatment with 50 mg/day or higher for medication-related deficiencies, and toxicity risks above 100 mg/day such as sensory neuropathy.

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    Vitamin Deficiency Diseases - B6

    Uploaded by

    Dr. Janarthanan V
    29 views12 pages
    This document discusses vitamin B6 (pyridoxine) and folate deficiency diseases. It provides information on recommended daily intake of vitamin B6, food sources, roles as a coenzyme, symptoms of deficiency including seborrhea and neuropathy, etiology such as alcoholism and medication interactions, clinical picture including anemia, lab diagnosis of low plasma pyridoxine levels, treatment with 50 mg/day or higher for medication-related deficiencies, and toxicity risks above 100 mg/day such as sensory neuropathy.

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    This document discusses vitamin B6 (pyridoxine) and folate deficiency diseases. It provides information on recommended daily intake of vitamin B6, food sources, roles as a coenzyme, symptoms of deficiency including seborrhea and neuropathy, etiology such as alcoholism and medication interactions, clinical picture including anemia, lab diagnosis of low plasma pyridoxine levels, treatment with 50 mg/day or higher for medication-related deficiencies, and toxicity risks above 100 mg/day such as sensory neuropathy.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    29 views12 pages

    Vitamin Deficiency Diseases - B6

    Uploaded by

    Dr. Janarthanan V
    This document discusses vitamin B6 (pyridoxine) and folate deficiency diseases. It provides information on recommended daily intake of vitamin B6, food sources, roles as a coenzyme, symptoms of deficiency including seborrhea and neuropathy, etiology such as alcoholism and medication interactions, clinical picture including anemia, lab diagnosis of low plasma pyridoxine levels, treatment with 50 mg/day or higher for medication-related deficiencies, and toxicity risks above 100 mg/day such as sensory neuropathy.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 12

    VITAMIN DEFICIENCY

    DISEASES
    PYRIDOXINE & FOLATE

    By-
    V.Janarthanan
    II-MBBS
    PYRIDOXINE :
    Vitamin B6
    >Pyridoxine, pyridoxal , pyridoxamine
    &their 5'-
    phosphate derivatives
    RDA :

    Infants – 0.3 – 0.6 mg


    Children – 1.0 – 1.4 mg
    Males – 1.7 – 2.0 mg
    Females – 1.4 – 1.6 mg
    Pregnancy – 2.2 mg
    Lactation – 2.1 mg
    SOURCES :
    • Plants contain vitamin B6 in the form of pyridoxine
    • Animal tissues contain PLP and pyridoxamine
    phosphate
    • The vitamin B6 contained in plants is less
    bioavailable than that from animal tissues
    • Rich food sources of vitamin B6 include legumes,
    nuts, wheat bran, and meat, although it is present in
    all food groups.
    COENZYMES :
    • 5'-Pyridoxal phosphate (PLP)

    • Cofactor for more than 100 enzymes involved in


    amino acid metabolism

    • Also involved in heme and neurotransmitter


    synthesis and in the metabolism of glycogen,
    lipids, steroids, sphingoid bases, and several
    vitamins, including the conversion of tryptophan
    to niacin.
    DEFICIENCY :
    • Seborrhea
    • glossitis
    • convulsions
    • neuropathy
    • depression
    • confusion
    • microcytic anemia
    ETIOLOGY :
    • Niacin intake/day - <0.2 mg

    • Alcoholism, isoniazid

    • Deoxypyridoxine, methoxypyridoxine

    • Isoniazid, L-dopa, penicillamine, and cycloserine


    interact with PLP due to a reaction with carbonyl
    groups
    CLINICAL PICTURE :
    • Epithelial changes, as seen frequently with other B
    vitamin deficiencies

    • In infants, diarrhea, seizures, and anemia have been


    reported

    • Microcytic, hypochromic anemia

    • Inflammation and elevated C-reactive protein levels.


    LAB DIAGNOSIS :
    • low plasma PLP values (<20 nmol/L).

    ADD-ONS :
     Used to treat carpal tunnel syndrome, premenstrual
    syndrome, schizophrenia, autism, and diabetic
    neuropathy but have not been found to be effective

     Vitamin B6 should not be given with L-dopa

     Pyridoxine should be given concurrently with


    isoniazid to avoid neuropathy
    TREATMENT :
    • 50 mg/d

    • 100–200 mg/d are given if vitamin B6 deficiency


    is related to medication use
    TOXICITY :
    • The safe upper limit for vitamin B6 has been set at
    100 mg/d.

    • Severe sensory neuropathy, leaving patients


    unable to walk.

    • Some cases of photosensitivity and dermatitis


    have also been reported.

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