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    Thiamine Pyrophosphate (TPP)

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    Kamali
    Thiamine pyrophosphate (TPP) is a derivative of vitamin B1 that serves as a common cofactor catalyzing several biochemical reactions. TPP is an essential cofactor for the pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase complex, transketolase, and branched-chain amino acid dehydrogenase complex. A deficiency of TPP can decrease the efficiency of these enzymes, slowing key metabolic processes and potentially causing beriberi symptoms like peripheral nerve degeneration.

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    Thiamine Pyrophosphate (TPP)

    Uploaded by

    Kamali
    32 views16 pages
    Thiamine pyrophosphate (TPP) is a derivative of vitamin B1 that serves as a common cofactor catalyzing several biochemical reactions. TPP is an essential cofactor for the pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase complex, transketolase, and branched-chain amino acid dehydrogenase complex. A deficiency of TPP can decrease the efficiency of these enzymes, slowing key metabolic processes and potentially causing beriberi symptoms like peripheral nerve degeneration.

    Original Description:

    Vitamin B1 functions reactions

    Original Title

    Thiamine Pyrophosphate (Tpp)

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    Thiamine pyrophosphate (TPP) is a derivative of vitamin B1 that serves as a common cofactor catalyzing several biochemical reactions. TPP is an essential cofactor for the pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase complex, transketolase, and branched-chain amino acid dehydrogenase complex. A deficiency of TPP can decrease the efficiency of these enzymes, slowing key metabolic processes and potentially causing beriberi symptoms like peripheral nerve degeneration.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    32 views16 pages

    Thiamine Pyrophosphate (TPP)

    Uploaded by

    Kamali
    Thiamine pyrophosphate (TPP) is a derivative of vitamin B1 that serves as a common cofactor catalyzing several biochemical reactions. TPP is an essential cofactor for the pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase complex, transketolase, and branched-chain amino acid dehydrogenase complex. A deficiency of TPP can decrease the efficiency of these enzymes, slowing key metabolic processes and potentially causing beriberi symptoms like peripheral nerve degeneration.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 16

    THIAMINE

    PYROPHOSPHATE (TPP)
    INTRODUCTION

     TPP is a derivative of Thiamine (vitamin B1)


     Common cofactor and catalyses several
    biochemical reactions.
    VITAMIN B1
    SYNTHESIS OF TPP
    REACTIONS

     Essential cofactor in multiple biochemical reactions


    including:
    a. Pyruvate dehydrogenase complex
    b. Alpha-ketoglutarate dehydrogenase complex
    c. Transketolase
    d. Branched-chain amino acid dehydrogenase
    complex
    e. Pyruvate decarboxylase in ethanol fermentation
    PYRUVATE DEHYDROGENASE:
    E1: Pyruvate
    Dehydrogen
    ase

    E2:
    Dihydrolipoyl
    Transacetyla
    se

    E3:
    LIPOAMIDE Dihydrolipoyl
    Dehydrogen
    ase
    ∝ KETO GLUTARATE DEHYDROGENASE
    E1: TPP deHase
    E2: Dihydrolipiamide
    succinyl transferase
    E3: Dihydrolipoamide
    deHase
    TRANSKETOLASE
    ‘MECHANISM
    OTHER FUNCTIONS OF TPP

     It plays an important role in tryptophan metabolism


     It activates chloride channels and hence helps in
    nerve conduction.
     It acts as an anti beri beri factor.
    DEFICIENCY SYMPTOMS:

     A deficiency of TPP will decrease the efficiency of


    enzymes that require TPP as a co factor.
     Rate of conversion of pyruvate to acetyl CoA,  keto
    glutarate to succinyl CoA and Pentose Phosphate
    pathway are slowed.
     Beri Beri
    BERI BERI

     Common causes: Alcoholism, long term starvation,


    dialysis without thiamine replacement.
     Effects:
    Degeneration of peripheral nerves
    Reduced cerebral blood flow
    Edema in feet and legs
    Potential heart failure

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