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    Thia Zoli Dined I Ones

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    Soumyadeep Mondal
    This document discusses thiazolidinediones, a class of oral hypoglycemic drugs used to treat diabetes. Thiazolidinediones, also known as glitazones, work by improving the body's sensitivity to insulin. Examples mentioned include troglitazone, rosiglitazone, and pioglitazone. Their mechanism of action involves selectively activating the nuclear receptor PPARγ, which regulates carbohydrate and lipid metabolism by increasing glucose transport and fatty acid metabolism in tissues like muscle and fat.

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    Thia Zoli Dined I Ones

    Uploaded by

    Soumyadeep Mondal
    26 views6 pages
    This document discusses thiazolidinediones, a class of oral hypoglycemic drugs used to treat diabetes. Thiazolidinediones, also known as glitazones, work by improving the body's sensitivity to insulin. Examples mentioned include troglitazone, rosiglitazone, and pioglitazone. Their mechanism of action involves selectively activating the nuclear receptor PPARγ, which regulates carbohydrate and lipid metabolism by increasing glucose transport and fatty acid metabolism in tissues like muscle and fat.

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    Thia Zoli Dined i Ones

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    This document discusses thiazolidinediones, a class of oral hypoglycemic drugs used to treat diabetes. Thiazolidinediones, also known as glitazones, work by improving the body's sensitivity to insulin. Examples mentioned include troglitazone, rosiglitazone, and pioglitazone. Their mechanism of action involves selectively activating the nuclear receptor PPARγ, which regulates carbohydrate and lipid metabolism by increasing glucose transport and fatty acid metabolism in tissues like muscle and fat.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    26 views6 pages

    Thia Zoli Dined I Ones

    Uploaded by

    Soumyadeep Mondal
    This document discusses thiazolidinediones, a class of oral hypoglycemic drugs used to treat diabetes. Thiazolidinediones, also known as glitazones, work by improving the body's sensitivity to insulin. Examples mentioned include troglitazone, rosiglitazone, and pioglitazone. Their mechanism of action involves selectively activating the nuclear receptor PPARγ, which regulates carbohydrate and lipid metabolism by increasing glucose transport and fatty acid metabolism in tissues like muscle and fat.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 6

    THIAZOLIDINEDIONES

    By-
    SOUMYADEEP MONDAL
    ROLL NO- 12401915047
    INTRODUCTION
     Thiazolidinediones are one of the most important class of
    drugs, mainly used as Oral Hypoglycaemics.
     The Thiazolidinediones are also known as “glitazones” are
    sometimes referred as Insulin Enhancers.
     They are exemplified from Ciglitazone, the first of these
    glitazones. The first drug to be marketed under this class is
    Troglitazone.
     Other examples of this class of drugs are Rosiglitazone and
    Pioglitazone.
     These drugs are used in combination therapy with Metformin,
    Sulfonylureas or Insulin.
     Glitazones lower blood glucose level by improving sensitivity
    to insulin in target tissues mainly adipose tissues, skeletal
    muscle, liver. These agents are dependent upon insulin for their
    activity.
    EXAMPLES OF THIAZOLIDINEDIONES
    O
    O

    NH
    NH H3C
    CH3 S
    S O
    O CH3 O
    O HO O

    CIGLITAZONE H3C CH3


    TROGLITAZONE

    O
    O O
    CH3
    NH
    N N S
    O S NH
    O N
    O
    H3C
    PIOGLITAZONE
    ROSIGLITAZONE
    MECHANISM OF ACTION
    Thiazolidinediones are selective agonists for nuclear peroxisome
    proliferator-activated receptor-γ (PPAR γ).
    1. These drugs bind to PPARγ, which activates insulin-
    responsive genes that regulate carbohydrate and lipid
    metabolism (thiazolidinediones require insulin to be present
    for their action (preferably Type II).
    2. Thiazolidinediones increase glucose transport into muscle
    and adipose tissue by enhancing the synthesis and
    translocation of specific forms of the glucose transporters.
    3. The thiazolidinediones also can activate genes that regulate
    fatty acid metabolism in peripheral tissue.
    4. Drugs act as agonist for PPARγ which then bind to DNA
    activating transcription of a wide variety of metabolic
    regulators and they enhance gene expressions.
    THANK YOU

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