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Factors To Surgical Site Infections

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Factors to Surgical Site

Infections
HO, ALEXANDER JR.
Harrop, J. S., Styliaras, J. C., Ooi, Y. C., Radcliff, K. E., Vaccaro, A. R., & Wu, C. (2012).
Contributing Factors to Surgical Site Infections
Journal of the American Academy of Orthopaedic Surgeons
Surgical Site Infection
Most common form of nosocomial infection
300,000 – 500,000 cases annually in the US
Responsible for appox 77% of all deaths in patients with nosocomial infection
Sequelae of SSIs
Revision surgery
Delayed wound healing
Increased use of antibiotics
Increased length of hospital stay
Hand washing
Single most critical measure in reducing the risk of transmitting microorganisms
Removes transient microorganisms and reduces resident microorganisms
Selecting an Antiseptic Agent
Alcohol was associated with the most rapid and greatest reduction in colony-forming units
(CFUs)

Chlorhexidine also demonstrated a reasonable reduction in CFUs; more importantly, however,


this agent had more persistent activity, which can be attributed to increased binding to the skin

Iodine was associated with the smallest reduction in CFUs and had little to no residual effect.
Bacteria returned to baseline levels after 6 hours
Scrub Duration
CDC recommends – 2 to 6 minutes
Surgical Site Skin Preparation
Approximately two thirds of all SSIs are confined to the surgical incision site
Endemic skin bacterial flora, such as gram-positive bacteria, account for most such infections
Surgical Site Skin Preparation
Randomized controlled trial of 234 patients

5-minute scrub using povidone-iodine followed by a paint with povidone-iodine or with


povidone-iodine paint alone.

Rate of SSI was 10% in both groups

CFUs were found on the skin in patients prepared with scrub and paint than in the patients
prepared with paint alone.
Selecting an Antiseptic Agent
2007 – Digison et al – Chlorhexidine in combination with alcohol proved to be the most effective
agent overall

Rate of infection
2009 – Swenson et al –
Povidone Iodine 4.8%
Chlorhexidine 8.2%

2010 – Darouiche et al - Rate of infection


Povidone Iodine 16.1%
Chlorhexidine 9.5%
Neurotoxicity of Chlorhexidine
Chlorhexidine
◦ Not used extensively in cranial and spine surgery
◦ Neuronal damage proportional to the concentration
◦ Damaged nerves do regenerate
Toxicity of Povidone Iodine
Significant corneal edema at >1.5%
Adhesive incision drapes
Cochrane review of 3,082 patients

Rate of infection
With 13.4%
Without 11.2%
Preoperative Hair Shaving
Facilitated skin marking
Clarified orientation for the surgeon
Expedited closure
Seemingly had the potential for reducing the risk of infection
Preoperative Hair Shaving
Microtrauma from hair shaving has been felt to increase bacterial colonization
Shaving adds to the length of surgery

10-year prospective study of 62,939 surgical wounds


Rate of infection
With Shaving 1.4%
(Electric Shaver)
With Shaving 2.5%
(Manual Shaver)
Without Shaving 0.9%
Operating Room Behavior
1,032 observations

Standard antiseptic protocol Vs Extensive antiseptic protocol

No significant difference was found between the two protocols

Rate of infection
Standard 14%
Extensive 15%
Operating Room Behavior
The four factors that had a particular impact on SSIs
◦ exchange of surgical team members
◦ movement in the operating room
◦ operating room noise
◦ presence of visitors
Operating Room Behavior
Largest role in increasing the risk of SSIs
◦ body mass index >30kg/m2
◦ surgeon experience
◦ duration of surgery
Surgical Duration
Surgical duration above the 75th percentile has been shown to be an independent risk factor for
SSI

>2 hours is an independent risk factor for SSI in both orthopaedic and general surgical patients

2010, Procter et al - prospective systematic study involving 299,359 operations in 173 hospitals
◦ Risk of infection increased 2.5% and that the odds ratio increased by 0.32 for every 30 minutes of
surgery
Surgical Duration
Exposure to airborne pathogens, considerable surgical trauma, and increased opportunities for
violations in sterile technique
Patient Related Risk Factors
Preexisting diabetes mellitus

Obesity

History of prior SSI

Methicillin-resistant Staphylococcus aureus (MRSA) colonization


Summary
Hand washing
Chlorhexidine scrub with duration of atleast 2 minutes
Chlorhexidine used for operative skin preparation
Adhesive incision drapes and preoperative shaving – limited effect in reducing SSIs
Shorter surgical time
Covering equipment whenever possible
Preventing intraoperative hypothermia
Limiting repetitive minor breaches in sterile technique
Patient-related risk factors do not appear to play as significant a role as perioperative factors

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