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    Biochip: Biosensor or Bioprocessor That Utilizes Technologies of Modern Biology and Electronics in A Micro Scale

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    Ashok Yadav
    Biochip is a biosensor or bioprocessor that utilizes technologies of modern Biology and Electronics in a micro scale. Physical methods are the keys for many biological problems DNA sequencing Protein structure Spectrophotometry Mass Spect Electron microscope Confocal Structure Determination An ideal biochip Size-portable Save energy-long term usage Low cost-mass production high sensitivity-integration Low sample requirement Microarray-high thru put Decreased invasiveness.

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    Biochip: Biosensor or Bioprocessor That Utilizes Technologies of Modern Biology and Electronics in A Micro Scale

    Uploaded by

    Ashok Yadav
    48 views30 pages
    Biochip is a biosensor or bioprocessor that utilizes technologies of modern Biology and Electronics in a micro scale. Physical methods are the keys for many biological problems DNA sequencing Protein structure Spectrophotometry Mass Spect Electron microscope Confocal Structure Determination An ideal biochip Size-portable Save energy-long term usage Low cost-mass production high sensitivity-integration Low sample requirement Microarray-high thru put Decreased invasiveness.

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    1231楊裕雄 Biochip

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    Biochip is a biosensor or bioprocessor that utilizes technologies of modern Biology and Electronics in a micro scale. Physical methods are the keys for many biological problems DNA sequencing Protein structure Spectrophotometry Mass Spect Electron microscope Confocal Structure Determination An ideal biochip Size-portable Save energy-long term usage Low cost-mass production high sensitivity-integration Low sample requirement Microarray-high thru put Decreased invasiveness.

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    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    48 views30 pages

    Biochip: Biosensor or Bioprocessor That Utilizes Technologies of Modern Biology and Electronics in A Micro Scale

    Uploaded by

    Ashok Yadav
    Biochip is a biosensor or bioprocessor that utilizes technologies of modern Biology and Electronics in a micro scale. Physical methods are the keys for many biological problems DNA sequencing Protein structure Spectrophotometry Mass Spect Electron microscope Confocal Structure Determination An ideal biochip Size-portable Save energy-long term usage Low cost-mass production high sensitivity-integration Low sample requirement Microarray-high thru put Decreased invasiveness.

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    Biochip

    Biosensor or bioprocessor that utilizes


    technologies of modern Biology and
    Electronics in a micro scale.
    Types of Biochip
    DNA chip
    Protein chip
    Enzyme chip
    Lab-on-a-chip
    Biomolecular machine
    Biocomputer
    Physical methods
    are the keys for many biological
    problems

    DNA sequencing
    Protein structure
    Spectrophotometry
    Mass Spect
    Electron microscope
    Confocal
    Bio-physical methods
    DNA sequencing
    Protein structure
    Spectrophotometry
    Mass Spect
    Electron microscope
    Confocal
    Structure Determination
    An ideal biochip
    Size-portable
    Save energy-long term usage
    Low cost-mass production
    High sensitivity-integration
    Low sample requirement
    Microarray-high thru put
    Decreased invasiveness
    Laboratory of Enzyme and Protein Engineering, Department of Biological Science and Technology, NCTU
    ASI Atomic Scale Integration ULSI Ultra Large Scale Integration
    LSI Large Scale Integration SSI Small Scale Integration
    GSI Giga Scale Integration VLSI Very Large Scale Integration
    MSI Medium Scale Integration ZSI Zero Scale Integration
    Time evolution in computer technology from zero to atomic scale integration (Ciabrera et al., 1991; Nicolini, 1993).
    Features and factors of size reduction in microchip-based analysis
    TIBTECH DECEMBER 1999 (VOL 17)
    The size matter

    從分子的角度看生物與半導體晶片

    Laboratory of Enzyme and Protein Engineering, Department of Biological Science and Technology, NCTU
    Biomolecular Machine
    Microtubules and Their Motors

    Skeletal Muscle Myosin and muscle


    contraction
    A Proton Gradient Drives the
    rotation of Bacterial Flagella
    DNA as Molecular Machine
    Construction and operation of the
    molecular tweezers.
    A DNA-fuelled molecular machinemade of DNA
    Bernard Yurke*, Andrew J. Turber®eld*², Allen P. Mills Jr*, Friedrich
    C. Simmel* & Jennifer L. Neumann*
    NATURE | VOL 406 | 10 AUGUST 2000

    Name Sequence Domain 1 Domain 2


    A 5’ TGCCTTGTAAGAGCGACCAT CAACCTGGAATGCTTCGGAT 3’
    B 5’ GGTCGCTCTTACAAGGCA CTGGTAACAATCACGGTCTATGCG 3’
    C 5’ GGAGTCCTACTGTCTGAACTAACG ATCCGAAGCATTCCAGGT 3’
    F 5’ CGCATAGACCGTGATTGTTACCAG CGTTAGTTCAGACAGTAGGACTCC TGCTACGA 3’
    5’ GGTCGCTCTTACAAGGCA CAGCTAGTTTCACAGTGGCAAGTC 3’
    5’ GCAGGCTTCTACATATCTGACGAG ATCCGAAGCATTCCAGGT 3’
    F5’ CGCATAGACCGTGATTGTTACCAG CTCGTCAGATATGTAGAAGCCTGC ACGTCGAT 3’
    F5’ GACTTGCCACTGTGAAACTAGCTG CGTTAGTTCAGACAGTAGGACTCC TGTCCAGA 3’
    Biocomputer
    Memory-The design of a biochip: a self-assembling molec
    ular-scale memory, Protein Engineering, 1, 295 (1987)
    Switching devise-Biochemical switching devise: bio
    mimetic approach and application to neural network study, J. of Bi
    otech, 109, 109 (1992)

    Logic gate-A biochemical logic gate using an enzyme an


    d its inhibitor, Biotech Progress (1999)
    Wire-Femtosecond direct observation of charge transfer bet
    ween bases in DNA. Proc Natl Acad Sci USA, 19, 14052 (2000)
    Applications of DNA chip and microarray technology
    Pharmacogenomics (2000) 1(3):289-307
    Companies involved in developing microarray DNA-chip technology for pharmacogenomics
    (from A to V) Pharmacogenomics (2000) 1(3):289-307
    Components of a
    DNA microchip.
    Pharmacogenomics (2000) 1(3):289-307
    Types of transducer
    Electrical-current/voltage (FET, MOS),
    charge, dielectricity
    Optical-absorption, emission, phase change
    , polarisation/absorption (SPR), opto-ether
    mal
    Thermal
    Magnetic-NMR, mass spect
    Mechanical, frequency-surface acoustic wa
    ve, quartz balance
    Electrochemical
    Sensors
    Principle:
    Anode: semi-oxidation reaction
    Cathode: semi-reduction reaction
    Example: Biofuel cell
    GOD
    Anode: glucose gluconolactone + 2H+ + 2e-

    Laccase
    + -
    Cathode: O2 + 4H + 4e 2H2O
    Biofuel Cell (J.A.C.S. 2001, 123, 8630)
    Electronic Nose
    (Biosen. & Bioele. 14, 1999 9-18)
    Surface Plasma Resonance
    (SPR)
    Nanowire FET
    (Sience 293, 17, August, 2001)
    Semiconductor Devices as
    Sensors of Biological Reactions

    Photodiodes SAW

    Mass
    Light
    Enzymatic Modified
    Reaction Electron Electrode
    EnzymeFET Charge
    Heat

    Thermometer

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