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    Roger David Kornberg: Powered By: David Daniela National College Class XI-G "HCC"

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    Roger David Kornberg received the 2006 Nobel Prize in Chemistry for his studies on how genetic information from DNA is copied to RNA. He discovered the nucleosome, which involves around 200 base pairs of DNA wrapped around a histone protein octamer. Kornberg also made breakthroughs in understanding the regulatory gene Mediator and developed methods to visualize the atomic structure of RNA polymerase and its components to better understand the molecular mechanisms of transcription.

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    Roger David Kornberg: Powered By: David Daniela National College Class XI-G "HCC"

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    daniela
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    Roger David Kornberg received the 2006 Nobel Prize in Chemistry for his studies on how genetic information from DNA is copied to RNA. He discovered the nucleosome, which involves around 200 base pairs of DNA wrapped around a histone protein octamer. Kornberg also made breakthroughs in understanding the regulatory gene Mediator and developed methods to visualize the atomic structure of RNA polymerase and its components to better understand the molecular mechanisms of transcription.

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    Roger David Kornberg received the 2006 Nobel Prize in Chemistry for his studies on how genetic information from DNA is copied to RNA. He discovered the nucleosome, which involves around 200 base pairs of DNA wrapped around a histone protein octamer. Kornberg also made breakthroughs in understanding the regulatory gene Mediator and developed methods to visualize the atomic structure of RNA polymerase and its components to better understand the molecular mechanisms of transcription.

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    30 views9 pages

    Roger David Kornberg: Powered By: David Daniela National College Class XI-G "HCC"

    Uploaded by

    daniela
    Roger David Kornberg received the 2006 Nobel Prize in Chemistry for his studies on how genetic information from DNA is copied to RNA. He discovered the nucleosome, which involves around 200 base pairs of DNA wrapped around a histone protein octamer. Kornberg also made breakthroughs in understanding the regulatory gene Mediator and developed methods to visualize the atomic structure of RNA polymerase and its components to better understand the molecular mechanisms of transcription.

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    of 9

    ROGER DAVID KORNBERG

    Powered by: David Daniela National


    College Class XI-G "HCC"
     Roger David Kornberg (born April 24 1947) is an
    American biochemist and professor of biology at
    Stanford University School of Medicine.
     Kornberg received the Nobel Prize for Chemistry in
    2006 for his studies of the process by which genetic
    information from DNA is copied to RNA, "the
    molecular basis of eukaryotic transcripts.“
     Kornberg was born in St. Louis, Missouri, the eldest of
    three sons biochemist Arthur Kornberg, who won the
    Nobel Prize, and Sylvy Ruth (Levy), who was also a
    biochemist. He won licensee in chemistry from
    Harvard University in 1967 and Ph.D. in physical
    chemistry from Stanford in 1972.


    Kornberg and his father, Arthur
     Kornberg became a fellow postdoctoral research at the
    Laboratory of Molecular Biology in Cambridge,
    England and then an assistant professor of biological
    chemistry at Harvard Medical School in 1976, before
    moving to his current position as professor of
    structural biology at Stanford Medical School in 1978.
    Discoveries:
     Kornberg and his research group  The structure of a
    have made several fundamental
    discoveries concerning the phospholipid:
    mechanism and regulation of
    eukaryotic cell transcripts. He
    found "flip-flop" and lateral
    spreading phospholipid bilayer
    membranes. In 1970, Kornberg
    discovered the nucleosome as the
    basic protein complex
    chromosomal .In both the
    nucleosome, Kornberg found
    that about 200 bp of DNA are
    wrapped around a histone
    protein octamer.
     Kornberg has made a breakthrough that consists in
    sending signals that the regulatory gene called
    Mediator.
       As noted by the Nobel Prize committee, "the great
    complexity of eukaryotic organisms is actually enabled
    the smooth interaction between tissue-specific
    substances, enhancers in the DNA and mediator."
     The discovery of Mediator is therefore a true milestone
    in understanding the process of transcription.
     At the same time, what Kornberg watched
    these biochemical studies of the transcription
    process, he devoted two decades to the
    development of methods to visualize the
    atomic structure of RNA polymerase protein
    and its associated components.
     He recently extended these studies to obtain
    structural images of RNA polymerase
    associated with accessory proteins. Through
    these studies, Kornberg has created a true
    picture of how transcription works at a
    molecular level to another.
    Personal life:
     Kornberg has two younger brothers: Thomas B.
    Kornberg (b. 1948), a biochemist who characterized
    and purified DNA and Kenneth Andrew Kornberg
    (n.1950) an architect specializing in the design of
    biomedical and biotechnology laboratories and
    buildings.
     Lorch Yahli is married teacher with whom he has three
    children, two boys and a girl: Guy, Gil and Maya

    Thank you!

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