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ASTHMA

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ASTHMA IN CHILDREN

presented by Mbekeka Angella

presented by Mbekeka Angella


Defnition
Asthma is a chronic inflammatory disease of the
airways. Symptoms range from mild to severe,
intermittent to chronic.
Untreated or under treated, asthma can lead to severe
respiratory distress and in rare cases, sudden death.
It can be classified into acute and chronic asthma.

presented by Mbekeka Angella


GENERAL SIGNS AND SYMPTOMS OF
ASTHMA
Wheezing
Chronic or recurrent cough
Tight feeling in the chest
Shortness of breath
Rapid breathing
Nasal flaring
Anxiety
Feeling weak or tired

presented by Mbekeka Angella


Risk factors for developing asthma

A family history of allergy, eczema and asthma


Smoking in the home.
House dust and dust mites.
Premature Births < 36 weeks of gestation.
Presence of Pets in families

presented by Mbekeka Angella


Triggers:
Allergic- such as dust mites
Non-allergic- such as exercise, viral infections, smoke or
other irritants.
These triggers cause inflammation and afterwards,
tightening of the airway muscles.
Only those with allergic asthma have symptoms triggered
by allergens such as pet dander, pollen and dust mites.
About 80- 90 % of adults with asthma have allergic
triggers.

presented by Mbekeka Angella


Cont
The body attempts to expel the allergen/s by releasing
several chemicals including histamines, causing
sneezing, runny noses, watery eyes and broncho-
constriction.
Histamines cause bronchial smooth muscles to
contract which in turn, makes exhaling more difficult.
In a child with asthma, histamine can also trigger
asthma symptoms.

presented by Mbekeka Angella


Pathophysiology
Incase of a trigger factor for example allergens the
body tries to produce chemical histamine which brings
about a running nose, watery eyes and Broncho
constriction. These histamines in excess cause smooth
muscles of the bronchus to constrict making exhaling
very difficult bringing about a difficult in breathing,
wheezing etc.
There excess histamine release in the body tend to
exacerbate asthma attacks.

presented by Mbekeka Angella


Acute severe asthma. (STATUS
ASTHMATICUS)
Clinical diagnosis is defined by increasingly severe
asthma not responsive to drugs that are usually
effective.

presented by Mbekeka Angella


Features of acute severe asthma
Cyanosis or SaO2<92%.
Severe chest retractions and use of accessory muscles.
Inability to talk in an older child.
Silent chest on auscultation (minimal air exchange).
Pulsus paradoxicus >20mmHg (the difference in
systolic arterial blood pressure in inspiration and
expiration doesn’t normally exceed 10mmHg).
Lethargy or changes in mental status.
Hypercapnia (CO2 retention-PaCO2
>50mmHg/>7kpa.

presented by Mbekeka Angella


Management
Before specific therapy the patient must be given high
flow oxygen.
Subcutaneous adrenaline 0.01ml/kg/dose (max 0.3ml)
can be repeated twice, 20min apart.
Nebulised salbutamol or albuterol given every 3hrs.
IV hydrocortisone 6mg/kg/dose 6hrly for 24hrs.

presented by Mbekeka Angella


Management -cont
IV aminophyline 6mg/kg as a loading dose and then
5mg/kg/dose every 6hrs or 1mg/kg/hr. watch out for
signs of toxicity like tachycardia, vomiting,
arrhythmias.
Prednisolone orally 1-2mg/kg/day for 5 days.
No sedation should be given even if the child is
restless.

presented by Mbekeka Angella


Supportive therapy
Give oxygen at a concentration of 100%. Remember
all children with severe asthma are hypoxic. The SaO2
should be >95%.
Maintain hydration by IV fluids or NGT.
Antipyretics should be given if the child is febrile.
Antibiotic should be considered if particularly the
child has a high temperature or localizing signs on
CXR.

presented by Mbekeka Angella


Investigations
FBC
Oxygen saturation, capillary or arterial blood gases..
Blood chemistry- Na, K, Cl, bicarbonate, and glucose.
Chest X-Ray.

presented by Mbekeka Angella


Cautions
If despite the above treatment the child’s condition
does not improve or worsens, then refer immediately
to the intensive care ward for intubation and artificial
ventilation.
Remember that all that wheezes is not only asthma.
Consider other possibilities if it is the first episode and
response is poor.

presented by Mbekeka Angella


Complications
Pneumothorax .
Lung collapse.
Mediastinal empysema.

presented by Mbekeka Angella


Follow up
Continue oral steroids at discharge for a total of 5
days.
Metered dose inhaler of β2 agonists for mild
attacks.
Home nebuliser for moderate asthma attacks.
Inhaled steroids or sodium chromoglycate if the
child has recurrent admissions for severe asthma.
Counselling of the child about precipitating factors
(e.g. pollution, smoking, dust), explain drug
management and when they should bring their
child to hospital (e.g. signs of severe distress: baby
not breastfeeding, child unable to talk.)
presented by Mbekeka Angella

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