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Disorders of Integrative Function 2 - 2020

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Disorders of

Integrative Function
Pathophysiology 2020-2021
Ms. Cres P. Quinzon RN MAN
OBJECTIVE
S
1 3
Discuss the Describe the time
mechanisms of course of
fatigue. physiologic
responses
2 associated with
Differentiate immobility and
between acute prolonged bed
and chronic rest.
fatigue in terms
of etiology and
onset
Activity Tolerance and Fatigue
Are they the same?
What Is A Normal Physical Activity?
• It is the process of energy expenditure for the
purpose of accomplishing an effect.
Disorders of Integrative Functions

• Activity intolerance: when there is less


physical and psychological energy to endure or
complete a desired activity.

• Fatigue: the sensation that comes with having


exhausted those energy reserves.
• depletion of reserves that makes it impossible
to complete an activity
Disorders Of Integrative Functions

• Fatigue is a subjective symptom with both


acute and chronic illness.
• A feeling of just not feeling right and having a
lack of energy and motivation to do anything.

• Fatigue can be acute or chronic.


Disorders Of Integrative Functions

• Fatigue can be a normal physical response,


such as that following extreme exercise in
healthy people, or it can be a symptom that is
experienced by people with limited exercise
reserve, such as people with cardiac or
respiratory disease, anemia, or malnutrition, or
those on certain types of drug therapy.
• Fatigue also may be related to lack of sleep or
mental stress.
Disorders Of Integrative Functions

• Is tiredness same as fatigue?


• Tiredness can be relieved by rest but fatigue
always persist.
Physiological Pathological
Treatment related
1. Environmental chemotherapy, radiation
Factors
excessive noise, temperature therapy, surgery,
extremes, changes anesthesia, diagnostic
in weather testing

Mechanisms
2. Drug Psychological
of Fatigue
Related
use of tranquilizers,
alcohol, toxic
stress,
monotony
chemical exposure

3. Physical Exertion
exercise
ACUTE FATIGUE CHRONIC FATIGUE
Etiology • Also known as muscle hypothyroidism, anemia, heart
fatigue disease, Lyme disease,
fibromyalgia, lung disease,
• Associated with increased electrolyte dysfunction,
activity or exercise to the tuberculosis, hepatitis, and cancer
point of exhaustion (CHRONIC HEALTH Problems)
(depletion of energy sources)

• Associated with viral or


bacterial infection

• may present with other


systemic symptoms such as
fever and body weakness

Onset Rapid relieved shortly after Complex, delayed and difficult to


the activity ceases diagnose

Relieved when the effects of the


disease are corrected
Time Course of Physiological Response Associated with
Immobility and Prolonged Bedrest
Duration Alteration
During 1st 3 days • Massive diuresis
• increase serum osmolality
• Increase hematocrit
• Na and Chloride excretion
On day 4 • Stable fluid loss

On day 4 to 7 days • Fibrinogen and fibrinolytic activity increase (clotting


(hemolytic and cardiovascular time prolonged)
changes) • Decrease cardiac output and stroke volume
• Metabolic rate decrease

On day 8 to 14 • Number of RBC’s decrease


(additional effects on hemolytic • phagocytic ability of leukocytes is reduced
system) • Decrease in lean body mass

On day 15 • Osteoporosis, hypercalciuria


Think & Link
• Patient is diagnosed with chronic fatigue
,which one is considered as a right
statement about this condition ?
A. The disease is rapid
B. Complex and delayed
C. Has no cure
D. Easy to diagnose
• Any questions?
THANK
YOU

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