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    Dna Repair: By:Saurabh Kumar Sharma M.SC Biotechnology 2 Semester

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    Saurabh Sharma
    This document summarizes different types of DNA repair mechanisms: direct repair, excision repair (including base excision repair and nucleotide excision repair), mismatch repair, recombinational repair, and repair of double-strand DNA breaks. It also discusses the importance of DNA repair for maintaining genetic stability, and the SOS response which enables cells to synthesize DNA repair enzymes in response to severe DNA damage. The key DNA repair pathways and their functions are outlined.

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    Dna Repair: By:Saurabh Kumar Sharma M.SC Biotechnology 2 Semester

    Uploaded by

    Saurabh Sharma
    68 views17 pages
    This document summarizes different types of DNA repair mechanisms: direct repair, excision repair (including base excision repair and nucleotide excision repair), mismatch repair, recombinational repair, and repair of double-strand DNA breaks. It also discusses the importance of DNA repair for maintaining genetic stability, and the SOS response which enables cells to synthesize DNA repair enzymes in response to severe DNA damage. The key DNA repair pathways and their functions are outlined.

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    dna repair mechanism

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    DNA REPAIR

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    This document summarizes different types of DNA repair mechanisms: direct repair, excision repair (including base excision repair and nucleotide excision repair), mismatch repair, recombinational repair, and repair of double-strand DNA breaks. It also discusses the importance of DNA repair for maintaining genetic stability, and the SOS response which enables cells to synthesize DNA repair enzymes in response to severe DNA damage. The key DNA repair pathways and their functions are outlined.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    68 views17 pages

    Dna Repair: By:Saurabh Kumar Sharma M.SC Biotechnology 2 Semester

    Uploaded by

    Saurabh Sharma
    This document summarizes different types of DNA repair mechanisms: direct repair, excision repair (including base excision repair and nucleotide excision repair), mismatch repair, recombinational repair, and repair of double-strand DNA breaks. It also discusses the importance of DNA repair for maintaining genetic stability, and the SOS response which enables cells to synthesize DNA repair enzymes in response to severe DNA damage. The key DNA repair pathways and their functions are outlined.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 17

    DNA REPAIR

    BY :SAURABH KUMAR SHARMA


    M.SC BIOTECHNOLOGY 2ND SEMESTER
    CONTENTS
     DNA REPAIR
     TYPES OF REPAIR
     DIRECT REPAIR
     EXCISION REPAIR
     MISMATCH REPAIR
     RECOMBINATIONAL REPAIR
     REAPAIR OF DOUBLE STRAND DNA BREAK
     SOS RESPONSE
    DNA REPAIR
    Although the genetic variation is important for
    evolution ,the survival of the individuals demands
    genetic stability also .Maintaining genetic stability
    requires not only an extreme accurate mechanism for
    replication DNA ,but also mechanism for repairing
    the many accidental lesions that occur continually in
    DNA
    Spontaneous changes in DNA are temporary because
    they are immediately corrected by a set of process
    known as DNA REPAIR
    IMPORTANCE OF DNA REPAIR

    Without repair system ,a genome would not be able


    to maintain its essential cellular functions.
    Most cells possess four different categories of DNA
    repair system
    Direct repair
    Excision repair
    Mismatch repair
    Recombination repair
    DIRECT REPAIR
    Direct repair systems act directly on damaged
    nucleotides,converting each one back to its original
    structure .but only a few types damaged nucleotide
    can be repaired directly
    EXCISION REPAIR
    Excision repair involves the excision of a segment of
    the polynucleotide containing a damaged
    site,followed by resynthesis of the correct
    nucleotide sequence by dna polymersae.There are
    two types of excision repair
    1.Base excision repair
    2.Nucleotide repair
    BASE EXCISION REPAIR
    NUCLEOTIDE EXCISION REPAIR
    MISMATCH REPAIR
     The mismatch repair system can detech mismatches
    that occur in Dna replication .Enzymes systems
    involved in mismatch repair are as follows:
     Recognise mismatched base repair
     Determine which base in the mismatch is the
    incorrect one
     Excise the incorrect base and carry out repair
    synthesis
    MISMATCH REPAIR
    RECOMBINATIONAL REPAIR
     Recombinational repair is a process of filling a gap
    in one strand of dsDNA by retrieving a
    homologous single strand from another dsDNA.It
    is a post replication process because it occur after
    replication
    REPAIR OF DOUBLE STRAND DNA BREAK

     Ionizing radiation ,oxidizing agents and replication


    errors may cause double strand break in DNA.If
    these lesions were left unrepaired,they would lead
    to trhe breakdown of chromosomes into smaller
    fragments
     The double strand break (DSB) can be repaired by
    the cellular non homologous end joining (NHEJ)
    pathway and homology directed repair (HDR)
    pathway.
    REPAIR OF DOUBLE STRAND DNA BREAK
    SOS REPAIR
     Many cells have mechanisms that enable them to
    synthesize DNA repair enzymes as an emergency
    response to severe DNA damage .The best studied
    examples is the SOS response in E.coli .The SOS
    response is a coordinated cellular response in e.coli
    and aids in the survival of the organism by
    affecting the expression of proteins.
    SOS REPAIR
    CONCLUSION
    Thank you to head of our deparment DR.SUDEEP
    SIR AND TO THE CLASS TEACHER OF
    MR.YUNUS SIR

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