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Applied Epidemiology: DR Hamid Hussain

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APPLIED EPIDEMIOLOGY

How to start to write a scientific paper

Dr Hamid Hussain

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Descriptive Epidemiology is the Antecedent to Analytical Epidemiology

 Descriptive Epidemiology
◦ To Describe the occurrence of disease fully,
some broad questions must be answered: Who is
affected? Where and When do the case occur? In
other words, it is necessary to specify person,
place, and time
 Analytic Epidemiology
◦ Testing a hypothesis about the cause of disease
by studying how exposures relate to the disease

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THE THREE ESSENTIAL CHARACTERISTICS OF DISEASE WE LOOK
FOR IN DESCRIPTIVE EPIDEMIOLOGY ARE:

 1.PERSON
 2.PLACE
 3.TIME

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 Age, gender, ethnicity
 Genetic predisposition
 Concurrent disease
 Risk taking behavior

◦ Diet, exercise, smoking


 SES, education, occupation

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 Age: Mortality and morbidity rates of almost all
conditions show some relation to this variable.

◦ Death rates are fairly high in infancy, then decrease


markedly, reaching lowest point between ages 5 and
14.
◦ The rate then climbs gradually until age 40, after
which it increases almost exponentially, virtually
doubling with each decade.

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 Sex: The analysis of disease rates by sex shows that
the death rates are higher for males than females, but
morbidity rates are generally higher in females.
 Ethnic group and Race: As many diseases differ
markedly in frequency, severity, or both in different
racial groups and statistics by race are helpful for
identifying health problems, therefore classification
and recording of data by ethnic group or race is
required.
 Other person variables are social class, occupation,
marital status, family variables (which include family
size, birth order, maternal age, and parental
deprivation), blood type, environmental exposures,
and personality traits, etc.

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 Geographic place
• presence of agents or vectors
• climate
• population density
• economic development
• nutritional practices
• medical practices

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 Calendar Time
◦ Diseases in 19th & 20th century
 Time since an event
◦ Hepatitis B after surgery
 Physiologic cycles
◦ Changes with life, puberty etc.
 Age (time since birth)
◦ Diseases of infants, adolescent, old age
 Seasonality
 influenza
 Temporal trends

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THE THREE PHENOMENA ASSESSED IN ANALYTIC
EPIDEMIOLOGY ARE:

HOST

AGENT ENVIRONMENT

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•Host Factors
•Personal traits (age, sex,
Host
race, customs, Occupation,
marital status, )
•Behaviors
•Genetic Predisposition
•Immunologic factors
Agent Environment

• Influence the chance for disease or its severity


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The Epidemiologic Triangle

•Agents
Host
•Biological (bacteria, virus)
•Physical (trauma, radiation)
•Chemical (poison, alcohol)
•Nutritional (lack, excess)

Agent Environment

• Necessary for disease to occur


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Environment
Host External conditions
(temperature, humidity, altitude,
crowding, housing, pollution)

Physical or biologic
or social

Agent Environment

• Contribute to the disease process


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 Due to new agent
 Due to change in existing agent

(infectivity, pathogenicity, virulence)


 Due to change in number of susceptibles

in the population
 Due to environmental changes that affect

transmission of the agent or growth of


the agent

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 …are often framed under the mantle of descriptive and analytic
epidemiology
◦ 1. Descriptive epidemiology – person, place & time
 Demographic distribution
 Geographic distribution
 Seasonal patterns etc.
 Frequency of disease patterns
◦ Useful for:
 Allocating resources
 Planning programs
 Hypotheses development

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 2. Analytic epidemiology
◦ built around the analysis of the relationship
between two items
 Exposures
 Effects (disease)
◦ looking for determinants or possible causes of
disease
◦ useful for
 Hypothesis testing

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