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    Spitz Nevi Dan Nodular Melanoma

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    Meta Sakina
    The document provides information comparing Spitz nevi and nodular melanoma. Spitz nevi typically present as single, dome-shaped papules or nodules that are red or pigmented and usually occur on the face or legs. They may grow rapidly at first then become static. Nodular melanoma typically presents as a rapidly expanding nodule that is often symmetric and well-circumscribed. They frequently reach 1 cm in size before diagnosis and may be ulcerated with colors of black, blue, or occasionally being amelanotic. Microscopically, Spitz nevi contain melanocytes without significant atypia while nodular melanoma contains markedly atypical melanocytes and often mitotic activity. Dermoscopically

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    Spitz Nevi Dan Nodular Melanoma

    Uploaded by

    Meta Sakina
    174 views5 pages
    The document provides information comparing Spitz nevi and nodular melanoma. Spitz nevi typically present as single, dome-shaped papules or nodules that are red or pigmented and usually occur on the face or legs. They may grow rapidly at first then become static. Nodular melanoma typically presents as a rapidly expanding nodule that is often symmetric and well-circumscribed. They frequently reach 1 cm in size before diagnosis and may be ulcerated with colors of black, blue, or occasionally being amelanotic. Microscopically, Spitz nevi contain melanocytes without significant atypia while nodular melanoma contains markedly atypical melanocytes and often mitotic activity. Dermoscopically

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    spitz nevi dan nodular melanoma

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    The document provides information comparing Spitz nevi and nodular melanoma. Spitz nevi typically present as single, dome-shaped papules or nodules that are red or pigmented and usually occur on the face or legs. They may grow rapidly at first then become static. Nodular melanoma typically presents as a rapidly expanding nodule that is often symmetric and well-circumscribed. They frequently reach 1 cm in size before diagnosis and may be ulcerated with colors of black, blue, or occasionally being amelanotic. Microscopically, Spitz nevi contain melanocytes without significant atypia while nodular melanoma contains markedly atypical melanocytes and often mitotic activity. Dermoscopically

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    174 views5 pages

    Spitz Nevi Dan Nodular Melanoma

    Uploaded by

    Meta Sakina
    The document provides information comparing Spitz nevi and nodular melanoma. Spitz nevi typically present as single, dome-shaped papules or nodules that are red or pigmented and usually occur on the face or legs. They may grow rapidly at first then become static. Nodular melanoma typically presents as a rapidly expanding nodule that is often symmetric and well-circumscribed. They frequently reach 1 cm in size before diagnosis and may be ulcerated with colors of black, blue, or occasionally being amelanotic. Microscopically, Spitz nevi contain melanocytes without significant atypia while nodular melanoma contains markedly atypical melanocytes and often mitotic activity. Dermoscopically

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 5

    HISTOPATOLOGI

    SPITZ NEVI MELANOMA NODULAR

    Two cylinders from typical Spitz nevi (H&E; original A large, well-circumscribed proliferation of atypical
    magnification: × 100 (a, b) and × 400 (c, d)).Epithelioid or melanocytes is seen growing throughout the dermis. The
    spindle melanocytes with no significant cytological atypia dermal melanocytes are enlarged with prominent, often very
    eosinophilic nucleoli, but with no tendency for maturation with
    progressive descent.

    The dermal component of a nodular melanoma is characterized


    by markedly atypical, usually epithelioid melano- cytes with
    lack of maturation and often a brisk mitotic activity.

    1
    DERMOSCOPY OF NODULAR MELANOMA
    SPITZ NEVI MELANOMA NODULAR

    The starburst pattern of pigmented Spitz (Reed) naevi. The pattern consists of a Typical nodular pigmented melanoma. A, This asymmetrical pigmented nodule has
    hyperpigmented centre and symmetrically distributed peripheral pseudopods (a, b) the significant positive predictors of blue-white veil, multiple (5-6) colors (scored
    or streaks (c) or a combination of pseudopods and streaks (d) from tan, dark brown, red, blue, gray, and black), irregular blotches, irregular
    brown dots and globules, and black color (Breslow thickness, 4.5 mm). B, This
    asymmetrical pigmented nodule has a blue-white veil, irregular blotches, and
    irregular dots and globules, some of which are black, that are found both in a
    central and peripheral position (Breslow thickness, 5.0 mm). C, This asymmetrical
    pigmented nodule has a blue-white veil, multiple brown dots (white arrows), 5 or 6
    colors, peripheral black dots and globules, milky red and pink areas, and irregular
    blotches (Breslow thickness, 6.7 mm). D, This asymmetrical pigmented nodule has
    peripheral black dots and globules, irregular dots and globules (size and
    distribution), pseudopods (arrow), and black color (Breslow thickness, 1.2 mm).

    2
    DERMOSCOPY OF NODULAR MELANOMA
    SPITZ NEVI MELANOMA NODULAR

    Symmetrical pigmented nodular melanoma.


    Although most nodular pigmented melanoma
    lesions have asymmetrical pigmented patterns,
    5.8% have symmetrical pigmentation, as seen
    here. The Breslow thicknesses are A, 1.7 mm; B,
    1.0 mm; C, 0.9 mm; and D, 4.3 mm.

    3
    DERMOSCOPY OF NODULAR MELANOMA
    SPITZ NEVI MELANOMA NODULAR

    Amelanotic/hypomelanotic nodular melanoma (NM). A, This


    hypomelanotic nodule has atypical vasculature shown as combinations of
    dotted (thick arrow), linear irregular (thin black arrows), and hairpin
    vessels (white arrows) (Breslow thickness, 2.2 mm). B, This lesion has a
    central white patch mimicking a dermatofibroma. A total of 12.9% of
    amelanotic/hypomelanotic NMs were reported to have central white
    patches. In this case the ulceration led to a suspicion of malignancy
    (Breslow thickness, 2.2 mm). C, This small-diameter hypomelanotic (light-
    colored) nodule has asymmetrical pigmentation with areas of blue-white
    veil (Breslow thickness, 0.94 mm). D, This hypomelanotic lesion has fine,
    predominantly linear irregular vessels at the periphery of the nodule
    (Breslow thickness,
    1.87 mm). E, This amelanotic nodule has diffuse hairpin vessels throughout
    the lesion in a symmetrical pattern (Breslow thickness, 2.0 mm).

    4
    GEJALA KLINIS
    SPITZ NEVI MELANOMA NODULAR

    The lesion tends to grow rapidly and may reach a size of an intraepidermal neoplastic component which involves
    1 cm within 6 months. Spitz nevi tend to become static less than three rete ridges at the edges of a dermal tumor
    after the rapid initial growth phase; however, color mass.
    changes may be observed, and bleeding and pruritus are
    rarely noticed

    Physical examination : Single, dome-shaped, red or The clinical features of NM are distinct from radial
    pigmented papules or nodules are typical. Most lesions growth subtypes. NMs typically present as a rapidly
    occur on the face or legs; rare cases of oral Spitz nevi Expanding papule, nodule, or plaque. They are
    were also reported.. The color may vary from occasionally polypoidal or even pedunculated .They are
    nonpigmented through pink to orange-red. Some lesions usually well circumscribed and sym- metric. NMs may
    are pigmented, especially those found on lower be detected when they are small in diameter but
    extremities. Note that the rare recurrences may mimic frequently reach a size of approximately 1 cm before
    metastatic malignant melanoma. diagnosis. Surface ulceration is not uncommon and their
    color is often black or blue, although a significant
    propor- tion are amelanotic. The amelanotic variety
    frequently has a subtle blush or peripheral rim of
    pigment that provides a crucial diagnostic clue.

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