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Ectopic Pregnancy

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Ectopic pregnancy

Introduction
• The three main categories of early
pregnancy disorders are:

• 1. spontaneous miscarriages
• 2. ectopic pregnancies
• 3. gestational trophoblastic disorders
(GTDs).
Pregnancy tests
• Human chorionic gonadotrophin is a
placental derived glycoprotein, composed of
two subunits, alpha and beta, which
maintains the corpus luteum for the first 7
weeks of gestation.

• Extremely small quantities of hCG are


produced by the pituitary gland and thus
plasma hCG is almost exclusively produced by
the placenta.
Definition:
An ectopic pregnancy occurs when the
conceptus implants either outside the
uterus (Fallopian tube, ovary or abdominal
cavity) or in an abnormal position within
the uterus (cornua, cervix).

 
Blastocyst implanted in the fallopian tube
Epidemiology and risk factors
• The incidence of ectopic pregnancy is
about 1 %.

• Between 95 and 98 percent of ectopic


pregnancies occur in the Fallopian
tube.
Site of ectopic pregnancy:
• Site of tubal ectopic pregnancy are:
• 1.More than 50 % of tubal pregnancies are
situated in the ampulla.

• 2. approximately 20 % occur in the isthmus.

• 3. around 12 % are fimbrial .

• 4.approximately 10 % are interstitial


Ectopic pregnancy
• Sites of Implantation
– Fallopian tube – most common site (ampulla) – 95%
– Ovary
– Uterine cornu
– Cervix
– Broad ligament
– Spleen 5%
– Liver
– Retroperitoneum
– Diaphragm
– Cesarean scar
Pathogenesis
Recurrence rate:
• The risk of recurrence is around
10 per cent and is increased in those who
have had a previous miscarriage or who
have suffered tubal damage.
Mortality rate
• mortality from ectopic pregnancy remains
high.
• representing 13 per cent of all maternal
deaths .
• The fatality rate of ectopic
pregnancy
is about four times that of
childbirth.
Ectopic pregnancy:
pathophysiology
- any mechanical or functional factors that prevent or
interfere with the passage of the fertilized egg to the
uterine cavity may be aetiological factors for an
ectopic pregnancy.
• Functional Factors : are
1.pregesteron only pill.
2. Intra uterine device.
3. Luteal phase defects
4.Cigarette smoking
5.Vaginal douching
pathophysiology

-It is believed that the main cause for a tubal


implantation of the gestational sac is a low-grade
infection,

as approximately 50 % of women operated on for


an ectopic pregnancy have evidence of chronic
pelvic inflammatory disease.
pathophysiology
• A high proportion of women with a tubal pregnancy
miscarry during the early stages of gestation.

• The products of conception may persist for a


considerable period of time within the tube as one
form of 'chronic ectopic pregnancy', or they may be
gradually absorbed.
 

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