We are Ultrasound Professionals

ALPINION MEDICAL SYSTEMS

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We are Ultrasound Professionals

Part 01. Corporate Overview

Part 02. Technology Highlights

Part 03. Products

CORPORATE OVERVIEW
General Information

We are Ultrasound Professionals

Since we began our ultrasound business in 2007, we have focused on developing core technologies and delivering the
best value to our customers. As a value innovator in the medical industry, ALPINION progressively expands our
business scope vertically and horizontally in every ultrasound area.

Company Identity CEO

Alpinion Medical Systems Youngchun Choi

Establishment Employee
April 24, 2007 271 (as of December 2016)

Major Shareholder Sales

ILJIN Holdings (Acquired in 2008) 57M USD (2016)

Headquarters Overseas
Verdi Tower, 72, Digital-ro 26-gil, ALPINION USA
Guro-gu, Seoul, 0893, Korea ALPINION MEDICAL Deutschland GmbH
ALPINION GuangZhou Medical Systems
Website
www.alpinion.com
Philosophy

Mission To achieve value innovation to contribute to the healthier life of people

Vision2020 To become Korea's leading medical device company which realizes strong and sustainable growth

Innovation
Embrace change and enhance competitiveness

Customer Respect
Deliver the highest quality of healthcare
product and service

Harmony
Pursue growth in unison

Integrity
Talent Development Build open and honest relationships with
Develop new generations of professionals communication
to carry on our commitment to excellence
Milestone

Jump to leading
Lay the cornerstone Strengthen the basis Sustained growth
position
• Established VIMED (2007) • Expanded the E-CUBE line up • Launching new products • Leading medical device
• Acquired by ILJIN Group (2008) • Launched the HIFU system, • Reinforcing products’ company with strong and
• Launched the 1st E-CUBE system, Alpius 900 (2015) competitiveness continuous growth
E-CUBE 9 (2011) • Pursuing new medical device
business development

Phase 1. Phase 2. Phase 3. Phase 4.

2007 - 2011 2012 - 2015 2016 - 2019 2020 -
Business Portfolio
From Acoustic To Therapeutic,
We are Ultrasound Professionals.

ALPINION’s proprietary acoustic technologies range from diagnostic

Transducers transducers developed for application-dedicated scanning to
therapeutic transducers specialized for HIFU treatments.

ALPINION’s innovative ultrasound diagnostic systems,

Diagnostic provide the ultimate solution with its excellent imaging performance,
Ultrasound efficient workflow, and powerful software throughout a system’s
lifetime.

HIFU has been called the future of tumor treatment,

Therapeutic and is a highly precise and proven medical procedure that uses high-
Ultrasound intensity focused ultrasound in the non-invasive ablation of tumors
and pathogenic tissue.
Performance Highlights
2016 Turnover - $ 57 million
2011 - 2016 Cumulative
Sales - 10,147units

2011 - 2016
CAGR - 47%

Significant records on our fast growth

1 year 1.2 years
HIFU system for research/vet, VIFU From the 1st E-CUBE system
2000, To having 5 E-CUBE line-ups
From development to release 1 1.2
year years

1.4 2
years years From transducer development
From the 1st E-CUBE shipment
To the 1000th E-CUBE shipment To having a wide rage of portfolio

1.4 years 2 years

Global Sales Channel

ALPINION CIS
Germany Europe 5
24 N America
distributors
distributors 4
ALPINION
ALPINION HQ distributors
USA
ALPINION
China
MEA
24 ASIA
distributors 15
distributors

S America
13
distributors

3 Subsidiaries
85 Sales Distributors
TECHNOLOGY HIGHLIGHTS
Technology Highlights

Acoustic Technology Diagnostic Technology

(Transducer) (System)
1. Acoustic Technology
∙ In-housed R&D, manufacturing, and total inspection

Key advantages l

Fast Low Best Easy Expansion Fast & Accurate

Repair Maintenance Cost Compatibility to New Applications Full Automatic Inspection
1. Acoustic Technology

Crystal Signature™ PowerView™

-60 Conventional structure

Ultrasonic Matching Gear
n skin ns
Huma Le -65

Backing -70
block

Magnitude (dB)
-75

-80

Heat
-85

-90

-95

-100
1 2 3 4 5
Frequency (MHz)
[General PZT Image] [Crystal SignatureTM Image] [Cool Liner] [Ultrasonic Matching Gear]

Key advantages l High-resolution and deep penetration Key advantages l Deeper penetration and higher sensitivity

Crystal Signature™ maximizes the penetration to enable high-resolution PowerViewTM reduces energy and enhances efficiency of ultrasonic
imaging processes. Superior single crystal transducers result in a wide- wave propagation through heat dissipation of transducers to improve
bandwidth and higher sensitivity that provide higher resolution and signal sensitivity and image expressiveness, especially in FOV side view.
superior image quality to customers.
1. Acoustic Technology

ExFast 3D/4D™ SensitiView ™ Technology

per unit time

per unit time

Imaging planes

Imaging planes

[Previous 3D/4D Acquisition] [ExFast 3D/4DTM] [SensitiViewTM Technology Structure]

Key advantages l Fast volume acquisition Key advantages l Enhanced sensitivity and high-resolution

ExFast 3D/4DTM is a transducer technology which acquires volume data The high-performance low loss cable transfers high-sensitive signals for
as quickly as 24Hz in general fetal 3D/4D scans. optimum impedance matching with the system. The results are
significantly enhanced sensitivity and high-resolution images.
1. Acoustic Technology
∙ Featured Transducers

SVC1-6H SC1-4HS IO3-12 L3-12HWD

The world 1st The world largest The world 1st Wide view
The world-first single crystal The largest aperture single The world-first intra-oral 60mm of footprint
volume convex transducer crystal convex transducer transducer
2. Diagnostic Technology
∙ System Design

System Hardware Software Display

FleXcan™ Pro Optimal Imaging

Architecture SuiteTM Plus
• PIHI (Phase Inversion Harmonic Imaging)
• FTHI (Filtered Tissue Harmonic Imaging)
Wide Full HD LED Monitor with
Connectivity • SCI,(Spatial Compounding Imaging) IPS technology
• FCI (Frequency Compounding Imaging)
• DICOM 3.0 standard • SRI (Speckle Reduction Imaging) / FullSRI™
• MPPS (Modality Performed Procedure Step)
• Modality work list
• Xpeed™ High Resolution Touchscreen

Excellent Storage Capability Application-Dedicated Software

• USB • CUBE StrainTM,
• CD/DVD • Stress Echo
• Network storage connections • Elastography
• Needle VisionTM, Plus
• Volume AdvanceTM / Volume MasterTM
• Live HQTM
• Auto IMT
• Full Cardiac Measurement & report
2. Diagnostic Technology

FleXcan™ Pro Architecture Optimal Imaging Suite™ Plus

[Conventional]

[E-CUBE Series]

[Spatial Compounding] [Synthetic Aperture Technology]

Key advantages l Excellent image and efficient exams Key advantages l Crystal-clear image quality
ALPINION’s unique imaging platform, FleXcanTM Pro, is a software ALPINION’s integrated post-processing technology, Optimal Imaging
driven architecture applied with the raw data imaging processing SuiteTM Plus, provides clearer images in the borderline of organs by
technology thus to ensure excellent imaging performance and reducing artifacts and signal noises, and quickly optimizes the images for
efficient clinical exams. each application.
2. Diagnostic Technology
∙ Miniaturized Ultrasound System

Firmware OS

Digital H/W

Analog H/W

Acoustic Module
PRODUCTS

Diagnostic Ultrasound
ALPINION’s innovative ultrasound diagnostic systems, the E-CUBE
series, provide the ultimate solution with its excellent imaging
performance, efficient workflow, and powerful software throughout
a system’s lifetime.
System Line-up
Performance

Price
Transducer Portfolio

Convex

SC1-4H SC1-4HS SC1-6H SC1-6 C1-6 C5-8N

Linear

L3-8H L3-8 L3-12X L3-12H L3-12HWD L8-17X L8-17H

Phased Array

SP1-5X MP1-5X SP1-5 SP3-8

Endocavity

EV3-10X EC3-10X EV3-10H EC3-10H EV3-10 EC3-10

Volume

SVC1-6H SVC1-6 VC1-6 VE3-10H

Special

CW 2.0/5.0 TEE3-7 IO3-12 IO8-17

Frequency
Quality in your daily practice

Product Information

Applications General Imaging, OB/GYN, Cardiology, Orthopedics, etc

Design

21.5” Monitor & Motorized Lift Enhanced

10.4” Touchscreen Control Panel Computing Power

FullSRITM Auto NT Auto IMT

Features Needle Vision TM
Plus Live HQ TM
Stress Echo
Elastography Volume AdvanceTM CUBE StrainTM

Clinical
Images

[Elastography] [Liver in Dual Live mode] [Volume AdvanceTM] Weight : 106 kg Height : 1,413/1,848 mm
Width : 580 mm Depth : 895 mm
Touch your daily practice

Product Information

Applications General Imaging, OB/GYN, Cardiology, Orthopedics, etc

Design

21.5” Monitor & 512GB SSD Full Color Backlit

10.4” Touchscreen LED Control Panel

FullSRITM Auto NT Auto IMT

Features Needle VisionTM
Plus Live HQ TM
Stress Echo
Elastography Volume MasterTM CUBE StrainTM

Clinical
Images

[Live HQTM] [Renal Perfusion in DPDI] [Mitral regurgitation jet] Weight : 94 kg Height : 1,455/1,695 mm
Width : 590 mm Depth : 895 mm
 Continuous Innovation All-in-one Solution for Top Born Powerful and Compact
- Superior and Reliable Performers

[Carotid Artery Live Dual] [Renal PW Spectrum] [Live HQTM] [Stress Echo] [Kidney in Dual mode] [22-week fetal brain]

Weight : 89.5 kg Height : 1,340/1,570 mm Weight : 57kg Height : 1,355/1,425 mm Weight : 54 kg Height : 1,410 mm
Width : 590 mm Depth : 830 mm Width : 509 mm Depth : 670 mm Width : 540 mm Depth : 659 mm
Innovation Meets Portability, Indeed.

Product Information

Applications Anesthesiology, Emergency medicine, Musculoskeletal, Sport medicine, General imaging, etc

Design

[Sliding Keyboard Cover]

FullSRITM Anatomical M-mode TDI

Features Needle VisionTM Plus XpeedTM Auto IMT
Panoramic Imaging CW

Clinical
Images

[Color Doppler] [Supraspinatus Tendon] [Renal Perfusion Weight : 7.2 kg Height : 84.9 mm
in Power Doppler] Width : 402.6 mm Depth : 366.5 mm
PRODUCTS

Therapeutic Ultrasound
HIFU has been called the future of tumor treatment, and is a
highly precise and proven medical procedure that uses high-
intensity focused ultrasound in the non-invasive ablation of
tumors and pathogenic tissue.
The safer and smarter choice
For the treatment of uterine fibroids : Ultrasound-Guided HIFU (High Intensity Focused Ultrasound)

Product Information

• Water circulation module • Easy and convenient control panel

Safe • Cavitation detection Quick • EZ Workflow TM
• Beam Steering

• 3D modelingTM
Accurate • Target ForecasterTM Compact • Portable
• Clear ViewTM

Clinical
Images

[Before] [After] [3 Month After]

Thank you