Menopause: Ms Bincy Joshwa
Menopause: Ms Bincy Joshwa
Menopause: Ms Bincy Joshwa
Ms Bincy Joshwa
Introduction
Climacteric : refers to the phase of decrease in ovarian
activity that begins 2-3 yrs before menopause and
progresses 2-5 yrs following it
Menopause and climacteric are used interchangeably
Onset of menopause occurs at 45-55 yrs of age
Endocrinal changes
The ovarian follicles reduce in no along with decrease
in estrogen and progesterone levels
The levels of inhibin also fall causing an increase in
FSH levels
FSH causes estrogen stimulation
Due to reduced no of follicles the FSH fails to
stimulate the production of estrogen
This results in failure of endometrial development and
absence of uterine bleeding which is observed as
menopause
Clinical features
Vasomotor symptoms: instability of thermoregulatory center due to
estrogen deficiency
Hot flushes
Night sweats
CNS symptoms: due to reduced serotonin levels
Insomnia
Palpitations
Psychological symptoms
Mood changes
Anxiety
Loss of memory
Loss of concentration
irritability
Alzheimers disease
Reproductive symptoms
Vaginal dryness
Loss of libido
Dyspareunia
Urinary symptoms
Urgency
Frequency
Dysuria
Chronic consequences
Osteoporosis
Cardiovascular disease and strokes
Diagnosis
History and physical examination
FSH >30 IU/L
Pap smear, lipid profile , blood sugar and bone density
Treatment
Emotional support
Counselling
Lifestyle modification –high fibre diet, low fat, rich in
antioxidants , exercise, smoking cessation and
decreased alcohol intake , relaxation and stress
reduction
Medications
Hormone replacement therapy
Who are symptomatic and high risk of developing
cardiovascular disorders, osteoporosis, Alzheimer’s
disorder or colonic cancer
Treated for 3-6 mnths and symptoms are relieved at the
ned of 6 mnths
Estrogen therapy is advised in lowest possible dose that
relieves vasomotor symptoms , prevents vaginal atrophy,
prevents acceleration of atherosclerosis
Estrogen -0.625 mg
Progestins-MDPA 5mg for 2 weeks every mnth
Weight bearing excercises
Adequate ultraviolet exposure
Vitamin D>400 IU/day
Calcium supplemenatation -1000mg/d
Stop smoking and alcohol consumption
Avoid excessive caffeine
Post menopausal bleeding
Uterine bleeding that occurs more than 12 mnths after
the last menstrual period of a menopausal woman