Skin Cancer
Skin Cancer
Skin Cancer
Definition
Skin cancer is the abnormal growth of skin cells
Most often develops on skin exposed to the sun
the scalp, face, lips, ears, neck, chest, arms
and hands, and on the legs.
It can also occur on areas of your skin that rarely
exposed to sunlight.
palms, beneath your fingernails, the spaces
between your toes or under your toenails, and
genital area.
Skin cancer occurs when errors (mutations) form the
in the DNA of healthy skin cells. The mutations cause
the cells to grow out of control and form a mass of
cancer cells.
Cells involved in skin cancer
Squamous cells lie just below the outer surface
and function as the skin's inner lining.
Basal cells, which produce new skin cells, sit
beneath the squamous cells.
Melanocytes, which produce melanin, the
pigment that gives skin its normal color
Skin cancers start as precancerous lesions
(dysplasia). Some specific dysplastic changes
that occur in skin:
Actinic keratosis is a patch of red or brown,
scaly, rough skin, which can develop into
squamous cell carcinoma.
A nevus (mole), and dysplastic nevi are
abnormal moles. These can develop into
melanoma over time.
•Three main types
- basal-cell
- squamous-cell
- melanoma
Squamous cell
carcinoma may appear
as:
A firm, red nodule
A flat lesion with a
scaly, crusted
surface
Melanoma
Melanoma signs
A large brownish spot
with darker speckles
A mole that changes in
color, size or feel or that
bleeds
A small lesion with an
irregular border and
portions that appear red,
white, blue or blue-black
Dark lesions on your
palms, soles, fingertips or
toes, or on mucous
membranes lining your
mouth, nose, vagina or
anus
Risk factors
Fair skin
A history of sunburns
Excessive sun exposure
Moles
A family history of skin cancer
Weakened immune system
Exposure to certain substances
Increasing age
Diagnosing